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Biomedical subjects

J Palm

Publications and source records attributed to J Palm.

At least 19 recordsLinked to original sources
PubMed1992

A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine D-1 receptor activity.

The molecular electrostatic potentials for a selective dopamine D-1 receptor antagonist, 7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-methylbenzazepine (SCH 23390 (1], and a selective dopamine D-1 receptor agonist, 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SK&F 38393 (2], have been calculated in order to obtain an understanding of the nature of the interactions between the phenyl ring and the receptor. Analogues of 1 with conformationally constrained phenyl rings have also been studied. Based on this study, the conclusion is drawn that an important part of the interaction between the phenyl ring in the benzazepines and the receptor is due to electrostatic forces, and that the phenyl ring interacts with the same receptor site as the oxygen atom of the 8-hydroxy group.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed1977

Reactivity of rat placental cells with alloantisera.

The nature of the protection afforded the placental structure against the immunologic consequences that could result from maternal exposure to paternal alloantigens remains obscure. One problem has been difficulty in antigenically defining the individual cellular components of the intact placenta. These studies were designed to examine serologically, with specific antisera, five cell types isolated from the rat placenta. The results indicate that non-Ag-B antigens are present on the cytotrophoblast cells, while Ag-G antigens are absent on all the cells except an undefined population of fibroblasts. Of particular significance is the obvious absence of detectable surface antigens on the cells directly in contact with the maternal tissues, the trophoblast mononuclear giant cells.

Animals↗
PubMed1976

Histologic characteristics of cells cultured from rat placental tissue.

Laboratory animals, especially rats, have provided a comparative model for extensive research on maternal-fetal relationships. To identify individual placental cells for subsequent immunologic analysis, cultures of rat placentas were studied. Five cell types were observed, including: two histologically distinct giant cells, mononucleate and multinucleate, apparently formed by amitosis and fusion, respectively; small round cells; polygonal cells, probably cytotrophoblasts. Of particular interest are the small round cells which are phagocytic and morphologically similar to macrophages, cells known to be important in the immune response.

Animals↗
PubMed1975

Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats.

Injection of guinea pig spinal cord with complete Freund's adjuvant induces EAE in Lewis (Ag-B1) and DA (Ag-B4) rats, but not in rats of the BN (Ag-B3) strain. When BN is crossed with Lewis, susceptibility is determined by a gene linked to the Ag-B histocompatibility locus, but a much more complex mode of inheritance is involved when BN and DA rats are crossed. Six inbred strains possessing the Ag-B1 histocompatibility allele have been found to be susceptible to EAE. Evidence for recombination between the Ag-B locus and the gene determining susceptibility to EAE has not yet been obtained.

Alleles↗
PubMed1973

Genetic control of susceptibility to experimental allergic encephalomyelitis in rats.

Rats of the inbred strains Lewis and DA are highly susceptible to the induction of experimental allergic encephalomyelitis (EAE) while Brown Norway rats are resistant to this disease. Evidence has been obtained which suggests that a single dominant gene is associated with susceptibility to EAE. The locus controlling EAE susceptibility is closely linked to the Ag-B histocompatibility locus but is not identical to it.

Animals↗
PubMed1971

Differential immunofluorescence of fertilized mouse eggs with H-2 and non-H-2 antibody.

Mouse embryos at the two-cell and blastocyst stages, as well as unfertilized eggs, have been studied by indirect immunofluorescence for the expression of H-2 and non-H-2 histocompatibility antigens on surface membranes. Serologically-specific reactivity to non-H-2 antibody (H-3 and H-6) was observed as diffuse, patchy staining over the entire surface of the blastomeres at the two-cell stage. In contrast, no reactivity of two-cell or unfertilized egg embryos of four inbred strains was observed when antisera containing only multispecific H-2 cytolytic antibody were used. Antisera containing H-2 along with non-H-2 antibody of unknown specificity showed varying degrees of reactivity, which could be shown by absorption studies to be due to the non-H-2 content of the serum. The results suggest that the initial expression of histocompatibility genes varies and support the hypothesis that the appearance of these cell components may relate to specific stages of differentiation.

Animals↗