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Biomedical subjects

J Pajak

Publications and source records attributed to J Pajak.

41 records · Page 3Linked to original sources
PubMed1991

Skin manifestation of extramedullary relapse in adult with acute lymphoblastic leukaemia.

In the group of 75 ALL patients treated between 1980 and 1989, two women (ages 25 and 17, both FAB-L2 and CALLA +, after 56 and 34 months of continuous CR, respectively) were found to have a relapse manifested as a local infiltration of skin, with involvement of the adjacent lymph nodes in one patient. The leukaemic character of the skin infiltration was confirmed by skin needle aspiration and tissue biopsy expressing CD10 and CD24. Both patients were given intensified systemic chemotherapy and local X-ray irradiation. Complete remission was obtained with the disappearance of the skin infiltrations followed after 13 and 8 months, respectively, followed by a marrow relapse with symptoms of CNS involvement in one case. Both patients died because of treatment resistance (the overall survival time equalled 70 and 44 months, respectively).

Adolescent↗
PubMed1990

[Tetralogy of Fallot in children--management and results of treatment].

The authors present the results of surgical treatment obtained in 288 children with tetralogy of Fallot. In 127 children palliative procedures (pulmonary-systemic anastomoses) were employed, whereas 161 patients were subjected to total surgical corrections of the defect, performed in cardiopulmonary bypass. In 127 (79%) belonging to the latter group the correction was a single stage procedure, and in 34 (21%), it followed pulmonary-systemic anastomoses. Perioperative mortality rate in children subjected to single stage procedures was 12%, being lightly lower than the rate observed in patients subjected to two stage procedures. The analysis of operative results corrected for age revealed a higher mortality rate in children operated when less then two years of age (17%) in comparison to older patients (11%).

Adolescent↗
PubMedDate not supplied

Results of surgical treatment of congenital heart defects in children with Down's syndrome.

We analyzed early and late results of surgical treatment of 100 consecutive children with Down's syndrome (DS) and congenital heart defect (CHD) who were operated on between 1990 and 1997. Fifty had common atrioventricular canal (CAVC), 24 ventricular septal defect, 8 the ostium primum atrial septal defect, 8 tetralogy of Fallot (TOF), 3 patent ductus arteriosus, 3 the ostium secundum atrial septal defect, and 4 CAVC coexisting with TOF. In 93 patients total correction was performed. The total death rate was 6%. Death in the CAVC group was 8%, but it decreased to 2.7% during the past 3 years. The children who were followed up (from 7 months to 6 years; mean, 39 months) are in NYHA class I or II. There were no reoperations. The postoperative course was complicated by pulmonary infections in 38% of patients, which converted to generalized infection in 10% and was the cause of death in 8% of patients. These results indicate that CHD in DS children can be repaired with a low death rate and low incidence of severe mitral atrioventricular valve regurgitation in the CAVC group. A high incidence of severe infections can influence the final results. Repair of CHD in infancy helps to eliminate problems connected with congestive heart failure and pulmonary hypertension.

Adolescent↗
PubMedDate not supplied

Antioxidative properties of coenzyme Q10 and vitamin E in exposure to xylene and gasoline and their mixture with methanol.

Exposure to a mixture of solvents in industry is still a problem particularly in industrial laboratories. In the paint and laquer industry the employees are exposed to xylene (Rx) and gasoline (Rg). The influence of xylene and gasoline or their mixture with methanol on lipid peroxidation was evaluated in the presented paper. Antioxidative properties of CoQ10 or vitamin E were also tested. It was observed that xylene caused an increase of lipid peroxidation measured as a MDA level in all used concentrations, but gasoline only in very high doses. The mixture of xylene with methanol increased significantly MDA level, whereas gasoline with methanol did not influence lipid peroxidation. The character of interaction depends on hydrocarbons dose. CoQ10 and vitamin E are effective antioxidants lowering the increased MDA level caused by xylene, gasoline or their mixture with methanol, however the dose of CoQ10 should be adjusted to the strength of oxidative stress in order to avoid disadvantageous effect. CoQ10 is a more effective antioxidant in exposure to xylene rather than gasoline, but vitamin E acts better in exposure to gasoline decreasing the MDA level.

Adult↗