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Biomedical subjects

J Paciel

Publications and source records attributed to J Paciel.

26 records · Page 2Linked to original sources
PubMed1981

[In vitro blastogenic response of lymphocytes in pityriasis capitis and dermatitis seborrheica (using PHA-mitogen, Pityrosporum ovale and bacteria)].

63 patients with Pityriasis capitis (PC) "dandruff" and Seborrheic dermatitis (SD) as well as normal controls were studied. Antigenicity was checked "in vitro" by the lymphocytic transformation test. A significant transformation in the PC to P. ovale was observed while in SD it was to Stanphyloccocus and P. ovale. In view of results the authors suggest that there is a similar immunoalergic response in the host to those antigens. The clinic will differ according to the antigens. This is significant for a new local treatment and general.

Antigens, Bacterial↗
PubMed1980

[Leukocyte migration inhibition factor in acne vulgaris].

The inhibition factor of the leucocytic migration was studied in 26 patients with Acne Vulgaris, stages III and IV, being positive in all the cases. The LIF positive shows the mobilisation of lymphocytic population, answering an active and constant immunologic conflict. As the PA is antigenic, because it produces a blastification (TTL positive), we can say that it acts as antigen provoking immunologic mechanisms which help to explain the inflammatory processes at the pilo-sebaceous follicle in the AV.

Acne Vulgaris↗
PubMed1979

[Immunologic studies in polymyositis syndromes].

Sixteen cases of polymyositis were submitted to study. Out of these sixteen, nine showed no clinical or paraclinical evidences of cancer, and seven presented an associated cancer. In the first group, a normal immune response was observed, whereas in the second group this response was frankly depressed. Emphasis is laid on the significance of the immune response, not only in the diagnosis but as a fundamental factor in prognosis and treatment as well. An early treatment of polymyositis without cancer proved to be satisfactory. On the other hand, when a neoplasm was present, the course of the disease was satisfactorily modified only after the extirpation of the neoplasm.

Adult↗
PubMed1977

[Blastogenic response in vitro of lymphocyte acne vulgaris].

32 patients with different degrees of acne and 10 healthy controls were studied. On every one of them the test for lymphocytic transformation was performed looking for the range of blastogenic response, using PHA and CA. The positive findings with CA related to those obtained in normal subject would support the hypotesis that the cellular immunity as a response to CA antigens would be different in each patient according to the host local conditions.

Acne Vulgaris↗
PubMed1977

[The nitro-blue-tetrazolium test in acne vulgaris (9-12-77)].

41 patients with different AV stages were studied with the quantitative NAT test. In those cases where there was an inflammatory process (stages III and IV) it was positive, while in was negative. The authors consider the relation between this test and the positive Lymphoblastic Transformation Test to PA, which makes evident a coordinate action of the immune specific system and the granulocytic one. This facts show that AV at the inflammatory stage is an immunologic systemic process and not only a local one.

Acne Vulgaris↗
PubMed1977

[The inhibitor factor of leukocyte migration in acne vulgaris].

The inhibition factor of the leukocytic migration was studied in 26 patients with Acne Vulgaris, stages III and IV, being positive in all the cases. The LIF positive shows the mobilisation of lymphocytic population, answering an active and constant immunologic conflict. As the PA is antigenic, because it produces a blastification (TTL positive), we can say that it acts as antigen provoking immunologic mechanisms with help to explain the inflammatory process at the pilosebaceous follicle in the AV.

Acne Vulgaris↗
PubMedDate not supplied

[Celiac disease and HLA in a hospital population of Uruguay].

Since the description of the association of HLA-B8 antigen with celiac disease, it has been confirmed by many authors. The incidence of HLA-B8 antigen is higher in adults and children when it is compared to apparently healthy controls. Some authors found a reduction on the incidence of HLA-B7 antigen and others suggested that a higher incidence of HLA-B12 antigen in patients HLA-B8 antigen negative, is associated with celiac disease. We studied 19 unrelated patients with celiac disease and 64 controls. Their ages range from 18 months to 18 years old, onset of the disease was during childhood. We determined twelve antigens of the HLA-A locus and thirteen antigens of the HLA-B locus. We used the NIH Microlymphocytotoxicity Technique. The degree of association was computed by the relative risk and the results were statistically evaluated by the X2. The statistically significant increase in frequency was shown only for HLA-A29 The results did not show neither the higher incidence for HLA-B8 found by other authors, nor the higher incidence for HLA-B12; however HLA-B7 was not detected in our patients. The final decision on the association of HLA-A29 antigen with celiac disease in our population will require examination of a broader panel of probands.

Adolescent↗