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J P Witz

Publications and source records attributed to J P Witz.

At least 37 records · Page 2Linked to original sources
PubMed1987

A better prognostic value from a modification of lung cancer staging.

This prospective study analyzes the survival rate, according to TNM and staging, of 538 patients who underwent curative pulmonary resection for non-oat cell tumors and who survived the operative period. A total of 279 patients had Stage I disease, 113 Stage II, and 146 Stage III. The overall survival rates were 72% at 1 year, 54% at 2 years, 47% at 3 years, 43% at 4 years, and 39% at 5 years. The survival curves of Stages I, II, and III are significantly different. Nevertheless, in Stage I, T1 N0 tumors presented the best survival rate (71% at 5 years), and this was significantly different from those of all other groups. For Stage II, the survival curves were significantly different according to hilar or lobar location of N1. The survival rate of T2 N1 hilar tumors was similar to that of T2 N2 tumors. In Stage III, the survival of T3 N2 tumors was the worst of all classifications. These results may contribute to a reappraisal of the surgical classification. T1 N0 tumors are worthy, on their own, of forming Stage I. T2 N0, T1 N1 lobar, and T2 N1 lobar can constitute Stage II. Stage III or IIIa would comprise carcinomas classified T2 N1 hilar, T1 N2, T2 N2, and perhaps T3 N0 and T3 N1. T3 N2 should probably be isolated in a IIIb or IV stage.

Adenocarcinoma↗
PubMed1987

[Thymoma. Analysis of a series of 42 cases].

The authors have treated 42 patients with thymoma and report on their experience. The mode of discovery, and notably the thymoma-myasthenia association in 8 cases (20%), the diagnostic approach and the management of the disease--surgery alone : 18 cases, surgery combined with radiotherapy : 24 cases and/or with chemotherapy : 5 cases--were analyzed. The thymomas were classified according to the G.E.T.T. system after re-examination of the histological sections. The course of the disease was studied. The overall survival rate, which depends on tumoral stage, was 71% at 4 years and 69% at 10 years; 5 patients died of the disease and 9 of other causes, including 5 who presented with a blood disease. This series is compared with other published series. The frequency of myasthenia and the respective prognostic values of anatomico-surgical, histological and histo-immunological classifications are discussed.

Adolescent↗
PubMed1986

[Repeated surgery in primary bronchial cancer. Apropos of 18 cases].

Primary lung cancer treated by surgery may re-develop on another site. Eighteen patients were re-operated upon over a 14-year period (1970-1983) in the Thoracic Surgery Unit of Strasbourg (Prof. J. P. Witz) for a second cancerous localization. Complications and post-operative mortality were more frequent with ipsilateral excisions (8 cases) than with contralateral excisions (10 cases); this may be due to the technical difficulties associated with complementary pneumonectomy in a previously affected hemithorax. The diagnosis, usually obtained by radiography of the chest, resulted from regular, long-term surveillance of patients operated upon for lung cancer. In spite of the small number of cases in this series (1.5% of excisions for lung cancer during that period), there is no doubt that to re-operate patients with a new localization of cancer is the best therapeutic solution.

Aged↗
PubMed1986

[Value of a plan for surveillance of patients operated on for bronchial cancer].

The modalities and results of surveillance of 578 patients operated upon for bronchial cancer are reported. Planned surveillance, introduced in 1981, is compared with the surveillance carried out from 1977 to 1980. The plan includes 4 radiological and clinical examinations during the 1st year, 3 during the 2nd year, 2 during the 3rd year and 1 per year thereafter. Bronchial fibroscopy is performed 9 and 18 months after surgery. In the 3rd post-operative month 10% of the patients had died, 4% had been lost sight of, and 86% had presented themselves for control examination. Regularity in attending control sessions has improved since planned surveillance was introduced: on average, the number of examinations is complied with, without modifications in the out-patient/in-patient ratio. Endoscopies are performed in 70% of the cases. Multiplying control examinations does not noticeably increases the number of pathological findings. Many relapses diagnosed on symptomatic grounds were, in fact, inaccessible to radiology and endoscopy. Five out of 19 local-regional relapses were diagnosed by fibroscopy. It is concluded that there is no need to increase the number of consultations, and that the complementary examinations performed should be more carefully selected.

Bronchial Neoplasms↗
PubMed1985

Primary malignant melanoma of the esophagus.

Primary malignant melanoma of the esophagus is rare, and its symptoms are similar to those of squamous cell carcinoma. This tumor tends to be polypoid, pediculated, and irregular. Hematogenic and lymphogenic metastases are common. Surgical resection with reestablished continuity of the gastrointestinal tract is the treatment of choice, and postoperative irradiation may be useful. Despite these measures, however, the prognosis is poor, with a 5-year survival of 4.2%. The case of a 47-year-old man with esophageal melanoma is described, and a review of the world literature is presented.

Esophageal Neoplasms↗
PubMed1984

[Cylindrical cancer of the lung. Analysis of a series of 191 cases].

The authors analyse 191 cases of cylindrical carcinoma of the lung. Study of the clinical and radiological characteristics, as well as the course, revealed the following: the reduced male predominance of this type of lesion, the often distal site and the primary pulmonary nature. The prognosis is identical to that for squamous forms: 31% survivors at 5 years.

Adenocarcinoma↗
PubMed1983

Postpneumonectomy empyema does not improve survival in bronchogenic carcinoma.

There is much disagreement in the literature about the beneficial effect of postpneumonectomy empyema on survival following operation for bronchogenic carcinoma. We had the opportunity to gather data on 407 patients with this serious complication. The survival data for a group of patients with postpneumonectomy empyema and fistula were compared with those for another group without such complications. Our statistical analysis confirms that postpneumonectomy empyema does not improve life expectancy.

Bronchial Fistula↗
PubMed1983

[5-year survival of resected bronchial cancer. Multifactorial analysis of its prognosis].

Prognosis in patients having undergone surgery for a bronchial carcinoma (oat cell. carcinoma excluded) was studied by comparing, with two statistical methods, a group of 178 patients surviving five years and more (group I) and a group of 178 patients who died within five years (group II). The two groups had undergone treatment during the same period. Comparison of the two groups suggested that the following factors were indicators of a good prognosis: ratio weight-height within normal limits without recent weight loss, fortuitous detection of the carcinoma; normal aspect on bronchoscopy; T1 N0 type without vascular extension, limited exeresis. Recurrences of the carcinoma were generally observed in group II but could be present in group I. The differential prognosis between pulmonary metastases and a "new" bronchial carcinoma was difficult. Survival was finally determined by the frequency of recurrences and metastases. By a correspondences factorial analysis it was possible to separate and to define the main characteristics of the patients with a good prognosis and a long survival and of those with a poor prognosis and a short survival. However this proved to be exact in only 30% of the individual cases because occurrence of metastases was generally unforeseable. From these data it appears that surgery alone is indicated in only one kind of tumours; T1 N0 carcinomas detected by routine examinations.

Aged↗