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J P Strong

Publications and source records attributed to J P Strong.

At least 73 records · Page 4Linked to original sources
PubMed1987

Comparison of coronary atherosclerosis in middle-aged Norwegian and Japanese men. An autopsy study.

We compared the extent of lesions in the coronary arteries of autopsied middle-aged men from Oslo, Norway, with lesions in autopsied men of similar ages in Tokyo, Japan. Certain risk factors for coronary heart disease as serum cholesterol, triglycerides, and blood pressure were also available from these men in the two locations. Our comparisons reveal large differences in the extent of atherosclerosis between Oslo and Tokyo, which are reflected in the levels of the risk factors, particularly serum cholesterol levels. Our findings suggest that preventive strategies could retard the development of atherosclerosis and coronary heart disease without the economic and nutritional problems that affect technically underdeveloped societies where atherosclerosis and coronary heart disease are not prevalent.

Adult↗
PubMed1987

Clinical applications of the supraceliac aorta: anatomical and pathologic observations.

To assess the extent of atherosclerosis in the supraceliac aorta, we studied autopsy samples from 100 men with severe atherosclerotic disease and from 135 men who had died of noncoronary causes. In both groups, the extent of atherosclerotic involvement was consistently less in the supraceliac aorta than in the infrarenal aorta. For this reason and because of other desirable characteristics, the supraceliac aorta is useful as an anastomotic site for apicoaortic conduits; in cases of graft infection; in coarctation of the aorta, when a concomitant cardiac procedure has been performed; and when the infrarenal aorta is inaccessible.

Aorta, Abdominal↗
PubMed1986

Coronary and aortic atherosclerosis in young men from Tokyo and New Orleans.

Comparisons of atherosclerotic lesions in 25- to 44-year-old men from Tokyo, Japan and New Orleans, Louisiana, by age and cause of death, show significantly more extensive involvement with raised lesions in the coronary arteries and abdominal aorta of black and white men from New Orleans than in men from Tokyo. New Orleans white men have approximately 3-fold the raised lesion intimal surface involvement of their Japanese counterparts in both the aorta and coronary arteries. These findings suggest the need for more extensive and detailed comparisons of atherosclerotic lesions to provide the background information necessary for effective preventive efforts in these two industrialized, technically advanced societies.

Adult↗
PubMed1985

Coronary risk factors and their pathway of action through coronary raised lesions, coronary stenoses and coronary death. Multivariate statistical analysis of an autopsy series: the Oslo Study.

From 1972 to 1973, 16,202 Oslo men, aged 40 to 49 years, were examined for cardiovascular disease and coronary heart disease (CHD) risk factors. This report describes the results of autopsy examinations from 204 of 471 men who died in this cohort with regard to associations between selected risk factors and (1) raised coronary atherosclerotic lesions (RL), (2) coronary artery stenosis, and (3) CHD death. Total serum cholesterol and blood pressure levels were positively associated with all 3 measures of coronary atherosclerosis and its complications, both in univariate and multivariate analyses, whereas high-density lipoprotein (HDL) cholesterol was highly and inversely related. Triglyceride levels, cigarette smoking, social class and physical activity at work and at leisure were not significantly associated with either of the 3 measures. When RL was added to the model with stenosis as the dependent variable, the risk factors no longer appeared as independent; this is consistent with the hypothesis that these factors, when significant, work through the development of RL to produce stenosis. HDL cholesterol was the only risk factor independently and significantly associated with CHD death when RL or stenosis or both were put into the model for CHD. This points to the possibility of HDL cholesterol also working through mechanisms other than the prevention of RL and stenosis toward CHD death.

Adult↗
PubMed1985

Cerebral atherosclerosis in New Orleans. Comparisons of lesions by age, sex, and race.

We compared mean extent of atherosclerotic lesions in carotid and intracranial arteries at autopsy among age, sex, and race subgroups in New Orleans. Most comparisons were made within similar broad cause-to-death categories after excluding deaths due to diseases associated with increased amount of atherosclerosis. Use of this basal group of cases reduces the effect of selection bias due to cause of death in this autopsy population. Fatty streaks were present in the carotid arteries of almost all cases even in the youngest age group (10 to 14 years) and were more extensive in blacks than in whites. Raised atherosclerotic lesions increased with age in the carotid arteries of blacks from age group 15 to 24 years and in whites from age group 25 to 34 years; black men and white men had about the same amount of raised lesions, whereas black women consistently had more than white women. In the intracranial arteries, fatty streaks and fibrous plaques began from age 15 to 24 years; blacks had more raised lesions than whites, particularly in the oldest age group, 65 to 69 years. These findings and mortality data suggest that in the 1960s and early 1970s black men and women were more susceptible to cerebral atherosclerosis and cerebrovascular diseases than white men and women.

Adolescent↗
PubMed1985

Stenoses in the coronary arteries. Relation to atherosclerotic lesions, coronary heart disease, and risk factors. The Oslo Study.

Coronary heart disease is strongly associated with the presence of stenosis in the epicardial coronary arteries. This prospective autopsy study shows that the relationship between risk factors for coronary heart disease and the occurrence of stenosis is the same as between risk factors and coronary atherosclerotic lesions: serum cholesterol, systolic and diastolic blood pressure contribute to formation of coronary stenosis; high density lipoprotein cholesterol is inversely related to stenosis. None of the other risk factors for coronary heart disease, such as fasting triglycerides, smoking habits, social class, and physical activity at work and at leisure, was statistically associated with the occurrence of coronary stenosis. Additional statistical analyses show that these selected risk factors do not seem to have any independent influence on the development of coronary stenosis over and above that of the extent of raised atherosclerotic lesions.

Adult↗
PubMed1984

Coronary heart disease in young black and white males in New Orleans: Community Pathology Study.

The biracial population of New Orleans has a high overall mortality rate, high coronary heart disease (CHD) mortality rate, and high autopsy rate. In the New Orleans Community Pathology Study we investigated atherosclerosis and CHD in all deceased males aged 25 to 44 years, with major focus on the 52% of subjects from whom heart and arterial specimens were collected and evaluated according to standardized procedures. Morphologic correlates of CHD are the same in young black and white males. CHD mortality and mortality from cerebral hemorrhage, hypertensive heart disease, chronic renal disease, and diabetes are greater in young black males than young white males. Age, serum cholesterol, and hypertension were identified as important associated factors in the atherosclerotic process, as well as in CHD. The extent of coronary lesions seems to have decreased between 1960-1964 and 1969-1978 in young white males but not in blacks. Racial differences in coronary lesion involvement in non-CHD deaths are smaller than in our earlier studies.

Adipose Tissue↗
PubMed1984

Atherosclerosis and lipid composition of the abdominal aorta. Comparison of autopsied New Orleans and Guatemalan men.

Abdominal aortas from 78 Guatemalan men and 79 New Orleans white men were examined for lipid composition and for the extent of grossly visible atherosclerotic lesions. In the specimens examined, atherosclerotic lesions were more extensive in New Orleans than in Guatemala, confirming findings of studies performed 10 and 20 years earlier. Lipid accumulation differed greatly between the geographic locations with new Orleans specimens having more chemically determined lipids. Differences in lipid accumulation between New Orleans and Guatemala are more striking when expressed in terms of content (milligrams per 100 square centimeters than when expressed as concentration (milligrams per gram of dry defatted weight). Chemical analyses indicate that lipid accumulation in the aorta results principally from the atherosclerotic process rather than from aging. In the 15- to 24-year age group, the gross extent of fatty streaks was similar in both populations, but content and concentration of free cholesterol was significantly higher in New Orleans specimens than in Guatemalan specimens. This finding might be related to the more extensive development of raised lesions at later ages in New Orleans subjects.

Adolescent↗
PubMed1982

Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer.

The prevalence of adenomatous and hyperplastic polyps of the colon and the degree of involvement of the aorta by atherosclerotic lesions were evaluated in 842 autopsies from New Orleans. A positive statistical association between the two variables was found in white males under 75 years of age. In black males a positive correlation between atherosclerotic lesions and adenomatous (but not hyperplastic) polyps was found. The most extensive involvement of the aorta by atherosclerosis was found in patients in whom adenomatous and hyperplastic polyps coincided. The possibilities that dietary factors may account for these findings and its relevance in relation to colon cancer and coronary heart disease are discussed.

Adult↗
PubMed1982

Survey of serum cholesterol and triglyceride concentration and lipoprotein electrophoretic pattern in rhesus monkeys (Macaca mulatta).

Serum lipids and lipoproteins were surveyed during quarantine of a group of 811 wild-caught rhesus monkeys. No abnormalities indicative of dyslipoproteinemia analogous to the familial hyperlipoproteinemias in man were observed. Males had significantly lower mean cholesterol (134 mg/dl) and higher mean triglyceride (41.9 mg/dl) concentrations than females (155 and 37.5 mg/dl, respectively). Electrophoretic distribution of lipoproteins differed with sex. Cholesterol concentration and electrophoretic pattern had not attained steady state by ten weeks either in animals recently imported or in those conditioned in another laboratory for six months or more after import.

Animals↗
PubMed1981

Community pathology of atherosclerosis and coronary heart disease: post mortem serum cholesterol and extent of coronary atherosclerosis.

Little is known about the direct relationship between serum cholesterol and the extent of coronary atherosclerosis in human populations even though the association of serum cholesterol levels with risk of developing coronary heart disease (CHD) is well documented. The results of this study of men 25-44 years of age, residents of Orleans Parish, Louisiana, show a significant relationship between post mortem serum cholesterol levels and extent of more advanced lesions (raised lesions) in the coronary arteries in 110 autopsied white men, but not in the cases of 221 autopsied black men. When disease categories comprising CHD cases and non-CHD cases (basal group) were evaluated, the racial difference in the cholesterol-lesion associations persisted. The reason for the racial difference in the observed cholesterol-lesion association is not clear. Additional research, where younger age groups are included, and considering earlier lesions and other risk factors in different environments may help in clearing this question.

Adult↗
PubMed1981

Sudden death from coronary heart disease in young men: Pathologic findings.

Thirty-five of 40 young men whose deaths were caused by coronary heart disease died suddenly (less than 24 hours after onset of terminal symptoms). Many had myocardial necrosis or scars consistent with ischemic episodes that occurred hours, days, or months prior to death, yet 94% did not reach a hospital or receive medical care during the terminal episode. These results are from an investigation of 579 men, aged 25 to 44 years, who lived, died, and were autopsied in Orleans Parish, Louisiana. Among those who died of coronary heart disease, the vast majority had extensive advanced atherosclerotic lesions in the coronary arteries irrespective of suddenness of death. The frequent occurrence of gross scars indicative of healed myocardial infarction among young men, both black and white, who died suddenly of coronary heart disease may offer new hope that improved case finding might identify persons who could benefit from vigorous programs of early intervention.

Adult↗
PubMed1981

Community pathology of atherosclerosis and coronary heart disease in New Orleans. Morphologic findings in young black and white men.

Mortality from coronary heart disease is greater in young black men than in their white counterparts. On the other hand, the morphologic correlates of coronary heart disease, namely, coronary artery stenosis and occlusion, thrombus, and myocardial lesions are strikingly similar in coronary heart disease deaths regardless of race. Diseases related to atherosclerosis and coronary heart disease such as cerebrovascular disease, hypertension, diabetes, and chronic renal disease are also more frequent in young black men than in young white men, but the excess of coronary heart disease in blacks is evident irrespective of these diseases. Our findings are based on a community-wide survey of black and white men, 25 to 44 years of age, who lived, died, and were autopsied in Orleans Parish (county) Louisiana. Since the morphologic features of the disease are similar in the two races, investigation of risk factors is needed to further explain mechanisms associated with the relatively high coronary heart disease death rate in young blacks.

Adult↗