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Biomedical subjects

J P Realini

Publications and source records attributed to J P Realini.

33 records · Page 2Linked to original sources
PubMed1992

Oral contraceptive use and cardiovascular disease: is the relationship real or due to study bias?

BACKGROUND: Epidemiologic studies link oral contraceptive use with several cardiovascular events, but the literature is difficult to summarize, and potential biases remain poorly addressed. This study uses meta-analysis to summarize study results and to analyze the influence of study characteristics, including susceptibility to bias, on study outcome. METHODS: Forty-seven case-control and cohort studies of oral contraceptives and four cardiovascular events were coded for relative risk (RR) and study characteristics, including adherence to 14 bias-control standards. Key RRs were pooled to summarize findings for each disease type. Univariate determinants of the magnitude of the relative risks were identified, and partial correlation analysis was performed for each disease type. RESULTS: Relative risks were significantly greater than 1.0 for venous thromboembolism (RR = 2.8, CI = 2.4 to 3.2), stroke (RR = 1.8, CI = 1.6 to 2.0), and myocardial infarction (RR = 1.6, CI = 1.4 to 1.8), but not for death due to any cardiovascular cause (RR = 1.0, CI = 0.8 to 1.3). Study characteristics were diverse, and potential biases were frequently uncontrolled. For three of ten study characteristics identified as independently influencing relative risk, methodologically stronger studies of venous thromboembolism tended to have higher RRs. The RRs for stroke and myocardial infarction were lower in studies that were methodologically stronger with regard to variables identified as important. In studies of cardiovascular death, bias-control standards identified as important were generally well addressed by the studies. CONCLUSIONS: Oral contraceptive use does not appear to increase overall cardiovascular mortality. The associations noted with stroke and myocardial infarction may be due to methodologic flaws in the studies, while the association with venous thromboembolism is more likely to be valid.

Bias↗
PubMed1989

Depression and anxiety among Mexican Americans in a family health center.

A standardized interview including parts of the NIMH-Diagnostic Interview Schedule was used to determine the prevalence of depression (major depression or dysthymia) and generalized anxiety in a random sample of predominantly low-income Mexican American patients attending an inner-city family health center. Overall rates of current DSM-III-diagnosable depression and anxiety were similar to rates reported for other primary care patient populations in the United States. There were racial/ethnic and sex differences in the rates of these disorders, with Anglo females having disproportionately high rates. Among women, the rate of mental disorders was higher for those with many somatic symptoms, three or more children, low scores on a scale of family integration, and numerous missed appointments in the last year.

Adolescent↗
PubMed1989

Infant circumcision in an outpatient setting.

We conducted a retrospective evaluation of 442 infant circumcisions performed in an ambulatory setting. Procedures done with the Gomco clamp (Gomco Division, Allied Health Care, Buffalo, NY) and the Plastibell device (Hollister, Inc, Libertyville, Ill) were compared with respect to the frequency of complications. The overall complication rate was 6.8%. Bleeding requiring action by a physician occurred in 3.4% of cases and was significantly more common with the Gomco clamp than with the Plastibell device (p less than 0.05). There were no statistically significant differences between the two methods in the rate of infection or other complications. The rate of complications is comparable to previous studies of inpatient circumcision.

Ambulatory Surgical Procedures↗
PubMed1988

Screening for colorectal cancer. Issues for primary care physicians.

Fecal occult blood testing, proctosigmoidoscopy, and digital rectal examination have been recommended as screening tests for colorectal cancer in asymptomatic people. This article evaluates the advisability of recommendations by applying accepted principles of screening to the case of colorectal cancer.

Adult↗
PubMed1985

Oral contraceptives and cardiovascular disease: a critique of the epidemiologic studies.

Observational study designs used to investigate the relationship of oral contraceptive use to the occurrence of venous thromboembolism, stroke, myocardial infarction, and cardiovascular death include case-control, cohort, and mortality statistics studies. This analysis catalogs the findings of each of these epidemiologic studies, its statistical significance, and its performance with regard to scientific methodologic standards. An association between current oral contraceptive use and incidence of venous thromboembolism without predisposition has been consistently observed in case-control and cohort studies. Associations are less consistent for various types of stroke and for myocardial infarction. Only the Royal College of General Practitioners study found a significantly elevated risk of cardiovascular death with oral contraceptive use. The majority of mortality statistics studies offer little support for a relationship between oral contraceptive use and cardiovascular events. Major systematic problems in the epidemiologic studies include potential for bias in the detection of cardiovascular events and differences in the prognostic susceptibility of compared groups. Bias in the ascertainment of drug exposure is an unresolved issue for most of the case-control studies. Because of possible biases arising from methodologic deficiencies in these epidemiologic studies, questions as to the validity of the observed associations between oral contraceptive use and cardiovascular events should remain.

Australia↗
PubMedDate not supplied

Relationship between substance abuse and panic attacks.

This study was done to determine the strength of association between substance abuse and panic states, including subsyndromal panic, its temporal relationship, and self-medication for panic using abusable substances. A community-based sample was screened for panic using DSM-III-R criteria. Panic and matched control groups participated in a structured interview concerning the presence of substance abuse, use of substances to treat panic symptoms, and the age-of-onset of panic and substance abuse. Of 97 individuals with panic, 39% had abused at least one substance. None of the panic disorder-subsyndromal panic differences reached significance. Only 10% of subjects reported using alcohol and 6% reported ever using illicit drugs to treat their panic. The majority (63%) of those abusing alcohol reported that alcohol use began prior to onset of panic, and the majority (59%) of those abusing illicit drugs reported that drug use began first. This study documents the panic-substance abuse relationship even in those with subsyndromal panic. Substance abuse began prior to onset of panic and substances were used to self-medicate for panic attacks by only a few subjects.

Adult↗
PubMedDate not supplied

The evaluation and treatment of urinary incontinence in women: a primary care approach.

BACKGROUND: Urinary incontinence, the involuntary loss of urine severe enough to have adverse social or hygienic consequences, is a major clinical problem and a significant cause of disability and dependency. At least 10 million adults in the US suffer from urinary incontinence, including an estimated 15 to 30 percent of community-dwelling older persons. In spite of its high rate of occurrence, fewer than one-half of women with regular urinary incontinence seek medical help for their problem, either because of embarrassment or the perception that their symptoms are normal. METHODS: MEDLINE files were searched from 1970 to 1990 using the key words "incontinence," "prevalence," and "diagnosis" and for specific nonsurgical treatments. Only articles pertaining to adult women were chosen. RESULTS AND CONCLUSIONS: Urinary incontinence frequently can be diagnosed accurately by family physicians using basic tests in the office. Many women experience improvement of incontinence with properly employed behavioral and pharmacologic therapy. Other women benefit from referral for specialized evaluation and consideration for surgical therapy.

Adult↗
PubMedDate not supplied

Vaginal diaphragm rings in the treatment of stress urinary incontinence.

To assess the effectiveness of wearing vaginal diaphragm rings in the treatment of stress urinary incontinence, 10 women with genuine stress incontinence were studied. Patients underwent urodynamic evaluation and perineal pad testing before and after fitted diaphragm rings were in place. Patients kept symptom diaries for 1 week without the ring and then for 1 week with the ring. They also gave an overall subjective evaluation of their experience. Urodynamic findings were essentially unchanged by wearing diaphragm rings. Trends toward improvement were observed in the results of pad tests and symptom diaries. Four of the 10 women experienced clinically significant improvement in amount of urine lost during pad tests, number of leaks per week, and overall assessment of response. Vaginal diaphragm rings may be an effective treatment for some women with stress urinary incontinence.

Adult↗
PubMedDate not supplied

Obstetrician: a protocol system for a family practice clinic.

Physicians often base their medical practices on bodies of rote medical knowledge. Proper use of this type of knowledge requires thorough and consistent application of large sets of memorized facts--a mental function that is often difficult for the unaided human intellect. Programs such as OBSTETRICIAN can assume this function. Incorporating these programs into medical record systems offers the best hope that busy practitioners will use them.

Clinical Protocols↗
PubMedDate not supplied

Four hours a month.

Explore the source record for details and available documents.

Delivery of Health Care↗
PubMedDate not supplied

Factors affecting the threshold for seeking care: the Panic Attack Care-Seeking Threshold (PACT) Study.

BACKGROUND: This study was conducted to explore the phenomenon of seeking medical care for panic attacks and to identify factors associated with seeking care. METHODS: A community sample of adults was screened using the Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition. Subjects who had experienced panic attacks participated in a structured interview concerning their health care access and utilization, panic characteristics, comorbidity, illness attitudes and perceptions, and family characteristics. RESULTS: Forty-one percent of the subjects had not sought medical care for their panic attacks. Having to get someone to drive (RR [relative risk] = 1.8; P = 0.0026), inability to work because of panic (RR = 1.6; P = 0.0054), and a high treatment experience score on the Illness Attitude Scales (RR = 1.5; P = 0.034) independently predicted seeking care. Seeking support was also significantly associated with seeking care (t = -4.05; P = 0.0001). Care seekers tended to have more severe symptoms, stronger symptom perceptions, and more bodily preoccupation and to abuse drugs more frequently. Seeking care was not influenced by sex, race or ethnicity, stress, psychiatric comorbidity, family function, social support, or access to health care. CONCLUSIONS: Nearly one-half of persons with panic attacks do not seek care for their attacks. Those who seek care differ from those who do not in ways that have important implications for the understanding of this illness.

Adult↗
PubMedDate not supplied

Oral contraceptives and venous thromboembolism: a case-control study designed to minimize detection bias.

BACKGROUND: Previous epidemiologic studies of venous thromboembolism and oral contraceptive use are susceptible to bias in the detection of venous thromboembolic events. This case-control study uses a unique design to minimize the influence of detection bias. METHODS: Nonpredisposed women younger than the age of 40 years who underwent pulmonary angiography, lower extremity venography, or lower extremity duplex Doppler sonography at a large urban hospital were classified into a case group or control group based on results of their diagnostic studies. Medical records were reviewed for a history of current oral contraceptive use. RESULTS: Fifty-seven women met the study criteria during the 11-year study period. Seven of 9 women in the case group and 17 of 48 women in the control group were currently using oral contraceptives (odds ratio 6.38; 95 percent confidence limits 1.19, 34.2). CONCLUSIONS: The association previously noted between venous thromboembolism and oral contraceptive use is not due to bias in the detection of venous thromboembolic events.

Adult↗