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Biomedical subjects

J P Ragot

Publications and source records attributed to J P Ragot.

At least 19 recordsLinked to original sources
PubMed2002

[Diffuse sclerosing osteomyelitis of the mandible and SAPHO syndrome].

BACKGROUND: Diffuse sclerosing osteomyelitis of the mandible (DSOM) and SAPHO (synovitis, acne, palmo-plantar pustulosis and psoriasis, hyperosteosis, osteitis) syndrome are not commonly associated. SAPHO has not been described to date in the stomatology and maxillo-facial surgery literature in French. Were report here a homogeneous series of 12 patients with DSOM. MATERIAL AND METHODS: All patients had mandibular osteitis. RESULTS: Five patients with multifocal osteitis wre considered to present SAPHO syndrome because of the associated skin lesions. One patient with a unique focus of mandibular osteitis and palmo-plantar pustulosis probably had early-stage SAPHO syndrome. The diagnosis in the other cases was diffuse sclerosis osteitis of the mandible. DISCUSSION: We compared our series with those reported in the literature, emphasizing diagnostic and therapeutic difficulties. Diffuse sclerosing osteomyelitis of the mandible should be distinguished from microbial osteitis. Early diagnosis is required to avoid successive and unnecessary dental avulsions. There is a possible link between DSOM and SAPHO and all patients should have a complete work-up including whole-body scintigraphy to search for other foci. A biopsy is indicated to rule out malignancy. Nonsteroidal antiinflammatory drugs can improve patient comfort in this particularly long syndrome. Although the efficacy is demonstrated, surgery and antibiotics can only delay relapse for a few months.

Acquired Hyperostosis Syndrome↗
PubMed2000

A novel route to preussomerins via 2-arylacetal anions.

[reaction--see text] Dimerization of salicylaldehydes provided 6H,12H-6,12-epoxydibenzo[b, f][1,5]dioxocins in multigram quantities. Deprotonation-allylation of the benzylic acetals followed by further functionalization of the diallyl derivative and double Friedel-Crafts cyclization gave a novel preussomerin analogue which possessed the full carbon skeleton of the natural products.

Acetals↗
PubMed1993

Controlled clinical investigation of acute analgesic activity of nimesulide in pain after oral surgery.

A double-blind study was conducted to determine the dose-effect relationship of nimesulide and to compare the acute analgesic activity of this agent with that of placebo and niflumic acid. Patients undergoing extraction of an impacted third molar were randomised into 4 groups (nimesulide 100mg; nimesulide 200mg; niflumic acid 250mg and placebo). They were instructed to take their allocated treatment after the onset of pain, and to record the pain severity and relief during the following 6 hours. 134 patients were evaluated. There were significant differences between groups for each time of observation/efficacy parameter (Kruskal-Wallis test). Pairwise comparison (Duncan's test) showed that all 3 active medications were significantly different from the placebo. No substantial differences were found between any of the active treatments. Analogous results were obtained when the amount of rescue drug used (paracetamol) was compared. More positive judgements were reported by patients treated with an active compound than by those taking placebo.

Adolescent↗
PubMed1990

[Nerve sheath myxoma. A case involving the maxillary sinus].

A myxoma of nerve sheaths involving the maxillary sinus was observed in a 12 year-old boy. The tumour, necrotic and calcified in this central area, was detected by a radiological opacity. In this periphery, the histological features were characteristic, showing lobules surrounded by fibrous tissue. In these lobules, spindle-shaped or stellate tumour cells were scattered in an abundant "myxomatous" matrix. The child is in good health fifteen months after surgical treatment. The histogenesis of this rare tumor is discussed in relation to this case and to those cases previously reported in the literature.

Child↗
PubMed1987

[Histiocytosis X of the jaws. II. Structural, histo-enzymologic and immunohistochemical study].

A series of cases of histiocytosis X was studied by immunohistochemistry (20 cases), histoenzymology (5 cases) and electron microscopy (15 cases). The immunohistochemical methods showed in the majority of cells (histiocytes similar to Langerhans' cells), OKT6, HLA-DR ans S-100 protein antigens. Besides, Leu 4 antigen was also present on the surface of some cells. The histoenzymological analysis found acid phosphatase and specific esterases activities with a different repartition in histiocytes compared to macrophages. By electron microscopy, we detected the typical Birbeck granules. The signification of these granules and also the pathogenesis of the disease were discussed.

Fluorescent Antibody Technique↗
PubMed1987

[Histiocytosis X of the jaw. I. Anatomico-clinical study apropos of 61 cases].

61 cases of histiocytosis X of jaws were reported here. They occurred more often in man (72% of men) than in woman, with an average age of 27 years. The mandible was affected more frequently than the maxilla. Clinically, dental expulsion, gingival swelling, fractures or pain were the usual symptoms. Roentgenographic examination showed either central or peripheral (alveolar bone) osteolytic areas. The histologic diagnosis was easy when eosinophilic polymorphous leukocytes or histiocytes were preponderant. In the other cases, immunohistochemistry (positivity of S-100 protein) and electron microscopy (presence of Birbeck granules about paraffin embedded specimens) were of a great usefulness. The prognosis of the disease was mainly related to the diffusion of lesions to other skeletal portions or extraskeletal localizations (37% of our cases). It has been improved by combination of chemotherapy to surgery (despite of frequent recurrences), 40 upon 45 patients are well after a follow-up of 2 to 10 years after the last localization.

Adolescent↗
PubMed1986

[Neural tumors of the tongue. An anatomicoclinical study apropos of 13 cases].

During the ten last years, 13 neural tumors of the tongue have been observed in the department of stomatology and maxillo-facial surgery of Salpêtrière Hospital Paris (Prof. J.M. Vaillant): 4 amputation neuromas, 5 benign schwannomas, 1 malignant schwannoma, 2 neurofibromas and 1 multiple endocrine syndrome type III. The authors analyze the clinical and histological data from these case-reports; they point out difficulties encountered in the diagnosis, and the prognostic problems brought up by such infrequent lesions.

Adolescent↗
PubMed1984

[Role of cryotherapy in the treatment of small angiomas of the oral cavity].

Operative difficulties when attempting to treat oral cavity angiomas suggested the use, of cryotherapy for limited lesions. The technique is simple in use non-aggressive and has few after effects. The principle of cryotherapy has been known for a long time, but it was only in the 60's that it was applied in ophthalmology, neurology, dermatology, gynecology and the treatment of hemorrhoids, as a result of the availability of new products: Freon, liquid nitrogen. Conclusions as to the value of cryotherapy are drawn from results obtained in buccal mucosa affections treated by this method over the last four years.

Cryosurgery↗