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Biomedical subjects

J P O'Brien

Publications and source records attributed to J P O'Brien.

At least 91 records · Page 5Linked to original sources
PubMed1986

Isolated intervertebral disc resorption. A source of mechanical and inflammatory back pain?

Seven patients underwent anterior interbody spinal fusions to alleviate pain due to resorption of an intervertebral disc. The anterior annulus of the discs at operation was inflamed. The specimens were studied histologically, and the findings are discussed. The demonstration of inflammation in the anterior annulus together with the recent identification of nerve fibres in the anterior annulus now allows a better understanding of discogenic pain and its management.

Adult↗
PubMed1986

Nylon sublaminar straps in segmental instrumentation for spinal disorders.

A new modification of segmental spinal instrumentation is in an early stage of research and development. Preliminary evidence is most encouraging with respect to the advantages of the relative safety of insertion of the nylon strap around the neural arch. The facility with which the insertion and tightening of the strap can be employed reduces the operation time significantly.

Bone Wires↗
PubMed1985

Quarterly tax report.

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Clinical Laboratory Techniques↗
PubMed1985

Spondylarthrography: the demonstration of spondylolysis by apophyseal joint arthrography.

Twenty selected patients with spondylolysis have been studied following apophyseal joint arthrography. In each instance a communication with the defect of the pars interarticularis was demonstrated by the extension of contrast medium from injection into the adjacent facet joint. The clinical and radiological features are described. The anatomical basis of the abnormality is presented using macroscopic and radiographic correlation from a dissected cadaveric specimen of spondylolysis. Sixty-five per cent of the patients experienced significant relief of pain symptoms when long-acting local anaesthetic was introduced into the facet joint.

Adult↗
PubMed1985

Acute traumatic intraosseous disc herniation.

The clinical, radiologic, and discographic findings are reviewed in eight patients with acute traumatic intraosseous disc herniation. The syndrome should be considered in adolescent patients having severe back pain with limited radiation to the upper thigh, following significant compression/flexion stress to the spine. The intraosseous disc herniation can be confirmed by discography and reproduction of symptoms during the procedure is a helpful confirmatory feature. The radiologic natural history of the lesion is presented, and the role of bone scintigraphy is discussed. This type of injury may be responsible for considerable pain and disability in the adolescent age group and has proved extremely difficult to manage except by conservative treatment and analgesics.

Acute Disease↗
PubMed1984

1983 tax wrap-up.

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Charities↗
PubMed1984

Myelography in severe lumbosacral spondylolisthesis.

The radiological and myelographic appearances of 14 patients with severe lumbosacral spondylolisthesis have been reviewed in relation to compression of the cauda equina and their clinical symptomatology. Patients could be separated into two groups as defined by the position of the L5 neural canal. In Group 1, the arch was displaced downwards and the cauda equina compression was due to pressure from the L5/S1 disc and was related to the degree of listhesis. L5 root sheath abnormalities predominated in this group. In Group 2 the neural arch maintained a more normal position and the compression, which was unrelated to the degree of slip, occurred between the arch and the posterior aspect of the sacrum. S1 root lesions occurred in these patients due to pressure from the arch. Clinical symptoms and signs were also more prominent in this group.

Adolescent↗
PubMed1984

Destruction of elastic tissue (elastolysis) as a link between atherosclerosis and the temporal arteritis/polymyalgia rheumatica syndrome. Observations on an actinic factor in vascular disease.

Destruction (elastolysis) of the internal elastic lamina is frequently observed near early atherosclerotic plaques. Elastolysis and plaque formation are also found together in the temporal arteritis/polymyalgia rheumatica syndrome. Could it be that atherosclerosis and the syndrome are more closely akin than usually thought, with elastolysis acting as the pathogenetic link between them? A kinship of this nature is in accord with the growing recognition that elastin-related autoimmunity prevails in both these forms of vascular disease. A case can also be made out for the belief that the autoimmune reactions in internal vessels may be provoked by events in the integument where a slow but ultimately massive turnover of dermal and vascular elastic tissue takes place under the harmful influence of solar and other forms of actinic radiation.

Arteriosclerosis↗
PubMed1984

Spondylolisthesis: the angle of kyphosis.

A reproducible method of measurement of kyphosis in spondylolisthesis using the cranial surface of the fifth lumbar vertebra and the caudal surface of the first sacral vertebra is described. This measurement is useful in the prognosis of spondylolisthetic patients as the progression of slipping is determined by both the angle of kyphosis and degree of slip. The angle is also important in operative correction of spondylolisthesis. This method is readily used and reproduced in severe slips.

Adult↗