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J P Mattei

Publications and source records attributed to J P Mattei.

At least 37 records · Page 2Linked to original sources
PubMed1997

P-31 magnetic resonance spectroscopy demonstrates unaltered muscle energy utilization in polymyalgia rheumatica.

OBJECTIVE: To characterize muscle metabolic anomalies associated with polymyalgia rheumatica (PMR) using P-31 magnetic resonance spectroscopy (MRS). METHODS: Seventeen patients with PMR and 9 age-matched control subjects were investigated. The forearm flexor muscles were examined by P-31 MRS in a 4.7 T superconducting horizontal magnet (Biospec Bruker 47/30) during a rest-exercise-recovery protocol. The intracellular pH and the relative concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), ATP, and phosphomonoesters were measured every minute during the protocol. Based on the PCr and pH time-dependent changes during exercise and recovery, the rates of ATP production from PCr hydrolysis, glycogenolysis, and aerobic metabolism were calculated for each minute of exercise. RESULTS: At rest, the metabolic parameters [PCr]:[Pi], pH, and [PCr]:[ATP] were not significantly different between the PMR patients and the control subjects. During exercise, the energetic cost and the contribution of anaerobic and oxidative pathways to energy supply were similar in the 2 groups, as were the recovery kinetics of the phosphorylated compounds and pH. CONCLUSION: Muscle MRS does not confirm the findings of histologic and biochemical studies that suggest an alteration of mitochondrial function in PMR. No other modifications in glycolytic or glycogenolytic pathways or in proton handling were found that could indicate an alteration of muscle energetics in patients with PMR.

Adenosine Triphosphate↗
PubMed1997

[Uterine adenosarcoma. Apropos of a case of uterine and vaginal adenosarcoma with a corrected genital prolapse].

Uterine adenosarcoma is an apparently benign mixed tumor with a muller type epithelial component and a sarcomatous stromal component. We present a patient with remodeled genital prolapse who developed a bifocal localization in the endometrium and vagina. These tumors are uncommon, 8% of the sarcomatous tumors of the uterus. Their usual presentation may mimic cervical or endometrial polyps. Pathology is required for positive diagnosis which evidences the two components. The diagnosis may be missed at the first examination (two-thirds of the cases in certain series). Treatment is surgical with hysterectomy in peri- or post-menopaused women and tumoral excision or curettage in younger women. The prognosis is good but can worsen if invasion extends beyond one-third of the myometrial thickness or if pure sarcomatous transformation occurs.

Adenosarcoma↗
PubMed1996

Magnetic resonance imaging of the wrist in rheumatoid arthritis: comparison with other inflammatory joint diseases and control subjects.

The aim of this study was to evaluate magnetic resonance images (MRI) of the wrist of rheumatoid arthritis (RA) patients. MRI and plain X-ray of the wrists were performed in 15 patients with RA, 7 patients with another chronic inflammatory joint disease (CIJD), and 10 control subjects. Patients had only minor changes on plain X-ray. Coronal T1 weighted spin echo sequences were performed before and after an intravenous pulse of gadolinium (GD). Contiguous 3 mm thick slices were obtained. Synovitis was frequently objectivized in the two groups of patients. MRI detected far more erosions and central bone geodes than plain X-ray. Geodes were frequent among controls while cortical bone erosions were frequent in patients. Most of the erosions were enhanced after GD injection in the RA patients but not in the 2 other groups. Thus MRI is not only useful in diagnosing inflammatory changes of the wrist but also in distinguishing early stage RA from other CIJD.

Adult↗
PubMed1996

[Intestinal metastases of bronchopulmonary cancer. Apropos of a case].

Intestinal metastases are relatively frequent in lung cancer (4.7 to 14% in autopsy series) but rarely recognized clinically before severe complications due to hemorrhage or occlusion. We report a new case and review the literature. Digestive tract localizations should always be searched in case of bronchogenic cancer as prognosis is very poor. Mean survival is 4-8 weeks requiring adapted approach to the primary tumor.

Carcinoma, Squamous Cell↗
PubMed1996

[Abdominal actinomycosis. Apropos of a case].

Abdominal actinomycosis is a chronic suppurating granulomatosis caused by a Gram positive germ, Actinomyces. Manifestations of this rare disease are usually pseudotumoral syndrome leading to surgical exeresis. The diagnosis is obtained from the pathology report. We report a pseudotumor of the transverse colon which invaded the greater omentum and the anterior abdominal wall. From a review of the recent literature, we observed that most papers deal essentially with a relatively new entity, pelvic actinomycosis related to prolonged use of an intra-uterine device without medical surveillance.

Actinomycosis↗
PubMed1994

[Ruptures of the tendons of the hand and wrist in rheumatoid arthritis].

We report our experience with 23 patients with rheumatoid arthritis who presented 48 tendon lesions involving 32 extensor tendons and 16 flexion tendons. Translocations of healthy tendons, overlapping with adjacent healthy tendons and tendon grafts were performed. Results for extensor tendons, expressed as defect in residual extension were excellent in 8 patients, good in 5 and mediocre in 4. For flexor tendons, there were 2 excellent results and 5 mediocre results in terms of thumb-palm contact. Prevention by early synovectomy is particularly important.

Aged↗
PubMed1993

Aetiologies of male osteoporosis: identification procedures.

Secondary causes and risk factors assume far greater importance in male osteoporosis than in female osteoporosis. The principal problem in dealing with male osteoporosis, above all in young men, is the difficulty to find a curable aetiology. Six groups of aetiologies can be drawn up: toxic causes or causes due to a change in the general state of health, drug-induced causes, renal causes, hormonal causes, exceptional causes and lastly the idiopathic form. The minimum number of investigations necessary so as to be quite sure not to overlook these various aetiologies is proposed.

Adult↗
PubMed1993

[Chronic hepatitis C and Gougerot-Sjogren syndrome. Apropos of a case].

The authors report a patient with concomitant Sjögren's syndrome and chronic hepatitis C. Close associations between autoimmune liver disease, chronic hepatitis C, and Sjögren's syndrome have been demonstrated. The most likely hypothesis involves triggering of an autoimmune cascade by the hepatitis C virus. Prevalence of hepatitis C virus infection in patients with Sjögren's syndrome and potential therapeutic implications of this disease combinations remain to be determined.

Autoimmune Diseases↗
PubMed1992

Serum and synovial fluid osteocalcin in rheumatic diseases.

The mechanisms involved in juxta-articular bone destruction are poorly understood. Osteocalcin or gamma-carboxyglutamic acid (GLA) protein is a small non-collagenous bone protein. It is a sensitive marker of osteoblastic bone formation. Its seric variations in the serum in such rheumatisms as rheumatoid arthritis remain unclear. Further information on local osteoblastic activity may be obtained by assaying the level of osteocalcin in the synovium. Its serum level can be evaluated by radioimmunoassay. The same method can be used in the synovial fluid. Paired serum and synovial fluid samples have been assayed from 63 patients, 33 patients with inflammatory arthritis (rheumatoid arthritis, psoriasis, chondrocalcinosis, pyogenic arthritis) and 30 patients with mechanical joint effusion (osteoarthritis, meniscal lesions). Serum levels of osteocalcin were the same in the inflammatory group (m: 8.69 +/- 0.68 ng/ml) and in the mechanical group (m: 10.2 +/- 0.67 ng/ml). In the synovial fluid, the levels of osteocalcin were significantly lower in the inflammatory group (m: 3.27 +/- 0.40 ng/ml) than in the mechanical group (m: 6.91 +/- 0.47 ng/ml). The same results were obtained with the ratio of synovial fluid osteocalcin on serum osteocalcin. There was a significant correlation between serum and synovial fluid osteocalcin and an inverse correlation between synovial fluid osteocalcin and the number of synovial fluid cells. The present study suggests that periarticular osteoblastic depression, among patients with inflammatory arthritis, is likely.

Adult↗
PubMed1991

[Surgical treatment of ruptures of the rotator cuff].

This study analyses the results of 30 surgical repairs of the rotator cuff. The basic problem was degenerative pathology in which medical treatment had been tried previously in all cases. The type of treatment was based upon preoperative evaluation and arthro-CT scan in particular. Results were invariably good, with regression of pain and recovery of activity. Muscle power was significantly correlated with the value of the tendon repaired, this being reflected overall by incomplete recovery.

Adult↗
PubMed1984

[Anti-B-lymphocyte antibodies in rheumatoid polyarthritis. I.--1st findings in 22 patients].

Anti B and T lymphocyte antibodies were sought in the serum of 22 rheumatoid arthritis patients from the Marseille area. No immunization against T lymphocytes was found. In contrast anti B lymphocyte activity was demonstrated in every diluted serum tested against a panel of 21 cells. In these sera, the complement dependent cytotoxicity was of medium intensity (lysis - 50 to 90 percent), antibody titers were high (medium 1/512) and a zone phenomenon was observed in 14 out of 22 non-diluted sera. As a rule, serum reactivity was slightly higher at 4 degrees C than at 22 degrees or 37 degrees C but at the latter temperature, it seemed to be more related to the target cells than to the serum tested. These anti B lymphocyte antibodies were predominantly IgMs and were not autoantibodies. Their specificity is still under study but already appears to be wide and not HLA related. These antibodies reacted with 9 to 100 percent of the panel cells and 85 percent of the sera recognized over 50 percent of the cells. Thus the antigenic determinants were probably allotypes or idiotypes of Fab fragments from surface immunoglobulins of a B lymphocyte subpopulation. Thus far, no relationship has been demonstrated between the presence or the titer of these antibodies and clinical, biological or genetic features of rheumatoid arthritis. In the future, this method should simplify the detection of Ig seric groups. It already allows detection of antiglobulin factors which could play an immunoregulatory role in rheumatoid arthritis.

Adult↗
PubMed1983

[Pseudodementias. Clinical and pathogenic problems].

Since the initial description by Ganser and Wernicke at the beginning of the century, two types of problems have appeared in the history of the concept of pseudo-dementia. The clinical ones have been at the root of careful descriptions of the pseudodemential syndrome by the Anglo-Saxon authors of the sixties, and have emphasized the psychiatric etiology and the reversible aspect of the disorders. The others are concerned with the pathogenic problems coming from pseudodementia and take in consideration -- on the basis of bringing together the clinical and neuropsychological sides with subcortical dementia -- the mechanisms that could be common to the physiopathology of the degenerating, demential and psychoneurotic disorders. This article analyses the concept of pseudementia in this double view, dwelling on the clinical and diagnostic problems.

Alzheimer Disease↗
PubMedDate not supplied

[The mu rhythm of the vertex and its reactivity: an infrequent observation (author's transl)].

The possibility arose of recording an uncommon type of E.E.G. activity: the mu rhythm of the vertex. A patient aged 76 years developed transient blindness, followed by confusion, a homonymous lateral hemianopsia, and left sensory deficiency, probably due to a cardiac embolism. An electroencephalogram one week later demonstrated localized "'arceau" rhythm around the vertex and typical centroparietal pseudo-periodic spikes (PLEDS). These activities were no longer present three days later. The vertex mu did not react to opening of the eyes or clenching the fists. It reacted to stimuli (tactile or movement) of the lower limb contralateral to the affected cerebral hemisphere. The origin of rhythmic activities corresponding to different generators is discussed, and the probable pathological significance of the mu rhythm of the vertex emphasized.

Aged↗