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Biomedical subjects

J P Lin

Publications and source records attributed to J P Lin.

At least 73 records · Page 4Linked to original sources
PubMed1984

CT of thrombosed arteriovenous malformations in children.

Thrombosed arteriovenous malformations (AVMs) in children are rare lesions that may present with headaches or a seizure disorder. Thirteen patients (4 months to 21 years of age) with this lesion were examined with computed tomography (CT). In 11 patients surgical confirmation was obtained, and the other two patients were examined with follow-up CT scans. Angiography either showed an avascular mass (7/13) or was negative (6/13). CT showed a lobulated lesion (8/13), peripheral location (11/13), and minimal surrounding edema (8/13). All of the lesions were hyperdense prior to the administration of contrast material and all enhanced either slightly or not at all following contrast material administration. It is concluded that these characteristic CT features aid in making the diagnosis of thrombosed AVM. The major differential diagnosis is small intracerebral neoplasm.

Adolescent↗
PubMed1984

Computed tomography of the asymptomatic postsurgical lumbar spine: analysis of the physiologic scar.

Computed tomography (CT) has been shown to be an effective noninvasive means of imaging the lumbar spine in patients with suspected disk disease. The clinical and radiographic evaluation, however, of patients with new or recurrent symptoms after surgery for disk disease is fraught with difficulty. This report describes CT changes seen in seven asymptomatic volunteers scanned at various intervals after disk surgery and discusses the implications of these findings.

Contrast Media↗
PubMed1983

Intravenous digital subtraction angiography in the investigation of intracranial disease.

Eighty-six patients who presented with a variety of intracranial lesions were examined with intravenous digital subtraction angiography (IV-DSA). A grading system was used to evaluate the ability of IV-DSA to answer specific diagnostic questions regarding intracranial tumors, vasospasm following subarachnoid hemorrhage, lesions of the sella, dural sinus occlusion, and post-therapeutic embolization. Eighty-four per cent of the examinations provided clinically useful information. In 15% of the cases limited but useful information was obtained; only 1% of the examinations provided no useful information. We conclude that IV-DSA can routinely provide useful information in the evaluation of the variety of intracranial lesions described above.

Angiography↗
PubMed1982

Evidence for a noncholinergic nicotine receptor on human phagocytic leukocytes.

A noncholinergic nicotine receptor on human phagocytic leukocytes has been characterized using the binding of 3H-(d,1)-nicotine. The average affinity +/- standard deviation of (d,1)-nicotine for the receptor on neutrophils is 36 +/- 18 nM (n = 6). The binding is saturable with an average of 8.7 x 10(4) sites per neutrophil. Monocytes and to a lesser extent lymphocytes but not erythrocytes also display specific binding. Bound nicotine is dissociable from the receptor and is not metabolized. Only close structural analogs of nicotine bind to the receptor, which is stereoselective for the (d)-isomer. The receptor can be occupied by (1)-nicotine at concentrations present in the blood of smokers. It is suggested that some of the adverse effects of smoking on leukocyte functions may be mediated by a specific nicotine receptor.

Kinetics↗
PubMed1979

Pseudoaneurysm formation secondary to spontaneous thrombosis of a massive cerebral arteriovenous malformation.

A case of a large cerebral arteriovenous malformation (AVM) with spontaneous partial thrombosis and intracerebral hematoma is reported. The unusual and unique features of the radionuclide brain scan and cerebral angiogram are described. The characteristic angiographic features of residual tortuosity and dilatation or pseudoaneurysm formation at the bifurcations of the feeding arteries in a partially thrombosed cerebral AVM have not been described previously in the literature.

Adult↗
PubMed1979

The value of routine cranial computed tomography in neurologically intact patients with primary carcinoma of the lung.

The most common cerebral metastatic lesion is from carcinoma of the lung. Preoperative cranial computed tomography (CCT) with contrast enhancement was performed in 55 neurologically intact patients with a diagnosis of bronchogenic carcinoma; 3 patients (5%) demonstrated cerebral metastasis. CCT could spare a significant number of such patients from unnecessary surgery, with a net saving substantially greater than its cost.

Brain Neoplasms↗
PubMed1978

Computed tomography in herpes simplex encephalitis.

Nine patients with herpes simplex encephalitis examined by CT scan were reviewed. A total of 15 satisfactory scans was analyzed. The majority of our cases had CT scan abnormalities: lucency 63% (5 of 8, one case with suboptimal scan), mass effect 50% (4 of 8), abnormal contrast enhancement 57% (4 of 7). The earliest CT scan finding was lucency, presented in two out of three cases studied within 48 hours following onset of symptoms. The primary role of CT scan is to support the suspected diagnosis of herpes simplex encephalitis as well as to indicate the best site for brain biopsy and to permit early effective treatment with adenine arabinoside.

Adolescent↗
PubMed1977

Computed tomography in the postoperative care of neurosurgical patients.

By its ability to differentiate the densities of various intracranial tissues, computed tomography is an ideal tool to investigate the postoperative course and complications of neurosurgical patients. The most important immediate postoperative complications are intracerebral edema and epidural, subdural or intracerebral hematomas. The extent of surgical resection of neoplasms can also be studied easily by CT. The method of investigation and representative cases are described.

Adolescent↗
PubMed1977

Positive and negative contrast myelography in spinal trauma.

The myelograms of 60 acutely injured patients were reviewed. Positive contrast material (Pantopaque) was preferred in cervical and thoracic trauma manifesting bony deformity, in cervical trauma without bony deformity (in the prone position), in delineating the thoracic spinal cord in the frontal projection, and in lumbar spinal injuries. Negative contrast material (air) was preferred in cervical trauma without bony deformity, to delineate the thoracic spinal cord in the lateral projection and in chronic trauma to demonstrate cord atrophy. An experimental, water-soluble positive contrast material (Amipaque) may show the spinal cord advantageously in both the anteroposterior and lateral projections and may be more extensively used. A protocol has been devised, based on the analysis of the myelographic findings.

Adult↗
PubMed1977

Some aspects of the computed tomography of the head.

Computed tomography demonstrates intracranial neoplasms so clearly that nearly all early work in this field was limited to descriptions of the appearance of various lesions. Only recently have investigators directed their attention to the medical implications of the physical and pathophysiologic phenonmena that characterize this remarkable new technique. This paper will discuss recent work in these two areas and its clinical implications, and will examine the application of computed tomography to the evaluation of the postsurgical and postradiation patient.

Brain Edema↗
PubMed1976

Evaluation of pediatric hydrocephalus by computed tomography.

Computed tomography (CT) is a safe and reliable technique for the study of children with increased head circumference. Hydrocephalic children requiring drainage of cerebrospinal fluid may be shunted on the basis of the CT scan alone and their postsurgical course followed by serial CT scans thereafter. Any additional pneumographic studies required may be performed via the existing shunt tube, eliminating transcerebral catheterization and its attendant complications.

Brain Edema↗
PubMed1976

The normal anterior inferior cerebellar artery. Anatomic-radiographic correlation with emphasis on the lateral projection.

Previous descriptions of the course and anatomic relationships of the anterior inferior cerebellar artery (AICA), as visualized in the lateral projection, have not been found by the authors. Dissection and radiography of 32 injected human cerebella show that AICA and its major branches define the position of the pontomedullary sulcus; supra-olivary fossette; 5th-11th cranial nerves; brachium pontis; flocculus; great horizontal fissure; posterolateral fissure; superior semilunar lobule; inferior semilunar lobule; biventral lobule; foramen of Luschka; and the choroid plexus of the lateral recess of the 4th ventricle. With magnification and high-quality subtraction, AICA and its associated structures may be identified in the lateral projection in the large majority of patients.

Abducens Nerve↗
PubMed1976

The anterior inferior cerebellar artery in mass lesions. Preliminary findings with emphasis on the lateral projection.

Analysis of abnormalities of the configuration of the anterior inferior cerebellar artery in lateral projection facilitates diagnosis of posterior fossa masses. Cerebellopontomedullary angle lesions frequently cause arcuate posterior-inferior displacements of the rostrolateral artery or reversal of curvature of the ascending segment of the meatal loop. Vermian, hemispheric, intra-fourth ventricular, and suitably situated extra-axial masses alter the plane of the lateral loop of the caudomedial artery. Tonsillar herniation may be detected in patients with hypoplastic or absent posterior inferior cerebellar arteries by analyzing the relationship of the biventral segment of the descending or caudomedial artery to the foramen magnum.

Brain Neoplasms↗
PubMed1976

Evaluation of sellar and parasellar masses by computed tomography.

Computed tomography is the method of choice for initial evaluation of patients with potential suprasellar masses. In our experience, CT has proved completely reliable for detecting or ruling out the presence of a suprasellar mass, the direction and degree of parasellar extension, and the presence of any calcific or cystic component of the lesion. When multiple cut CT has been negative, further diagnostic studies have proved unrewarding. When CT has been positive, additional studies have been required in some cases to rule out aneurysm prior to craniotomy.

Adenoma↗
PubMed1976

Computed tomography in the diagnosis of extra-axial posterior fossa masses.

Extra-axial posterior fossa masses can be diagnosed reliably by computed tomography (CT) in most cases. Acoustic and trigeminal neurinomas, meningiomas, cholesteatomas, and other extra-axial masses can usually be distinguished from intra-axial masses by asymmetric widening of the basal subarachnoid spaces, bone destruction, continuity of the tumor mass with the tentorium or bone, and more sharply defined margins. Multiple-cut study of the posterior fossa improved visualization of the fourth ventricle and basal cisterns. Interpretation of cisternal changes in association with changes in the fourth ventricle and abnormal attenuation coefficients permits accurate diagnosis of posterior fossa masses.

Aneurysm↗