The role of the sympathetic nervous system in the circulatory response of the rabbit to arterial hypoxia.
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Animals↗
Biomedical subjects
J P Isbister
Publications and source records attributed to J P Isbister.
Effects of taipan (Oxyuranus scutellatus) venom on erythrocyte morphology and blood viscosity in a human victim in vivo and in vitro.
The case of a snake handler with envenoming due to Australian taipan (Oxyuranus scutellatus) showing marked morphological changes in his red blood cells is presented. The red cells underwent sphero-echinocytic transformation and in subsequent experiments in vitro the effects of taipan venom on red cells were further characterized. Taipan venom induced sphero-echinocytic transformation at nanogram/ml concentrations and led to a marked increase in whole blood viscosity. These changes have not been featured in previous reports of taipan envenomation and are reported to highlight the diagnostic value of blood film examination in cases of suspected envenomation. The significance of the hyperviscosity, and consequent reduction in blood fluidity, is unknown and requires further investigation.
Adult↗
Use of dextran 150 as a macromolecular agent to improve granulocyte yields on the intermittent flow blood cell separator (Haemonetics Model 30).
Leukaphereses were performed on the intermittent flow cell separator (Haemonentics Model 30) using citrated dextran 150 as a macromolecular agent to improve separation of granulocytes. A mean of 1.77 X 10(10) granulocytes and 7.73 X 10(11) platelets were obtained without steroid stimulation and 2.65 X 10(10) granulocytes and 8.91 X 10(11) platelets were obtained with steroid stimulation of donors. There were no significant adverse reactions to dextran.
Cell Separation↗