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Biomedical subjects

J P Hansen

Publications and source records attributed to J P Hansen.

At least 19 recordsLinked to original sources
PubMed2006

Nondipole ionization dynamics of atoms in superintense high-frequency attosecond pulses.

The ionization of H(1s) in superintense, high-frequency, attosecond pulses is studied beyond the dipole approximation. We identify a unique nondipole 3rd lobe in the angular distribution of the ejected electron and show that this lobe has a well-defined classical counterpart. The ionization is likely to occur in the direction opposite to the laser propagation direction, which is fully understood from an analysis of the classical dynamics.

Journal Article↗
PubMed2005

Strong orientation effects in ionization of H+2 by short, intense, high-frequency light pulses.

We present three-dimensional time-dependent calculations of ionization of arbitrarily spatially oriented H+2 by attosecond, intense, high-frequency laser fields. The ionization probability shows a strong dependence on both the internuclear distance and the relative orientation between the laser field and the internuclear axis. The physical features are explained in terms of two-center interference effects.

Journal Article↗
PubMed2005

Exact nondipole Kramers-Henneberger form of the light-atom hamiltonian: an application to atomic stabilization and photoelectron energy spectra.

The exact nondipole minimal-coupling Hamiltonian for an atom interacting with an explicitly time- and space-dependent laser field is transformed into the rest frame of a classical free electron in the laser field, i.e., into the Kramers-Henneberger frame. The new form of the Hamiltonian is used to study nondipole effects in the high-intensity, high-frequency regime. Fully three-dimensional nondipole ab initio wave packet calculations show that the ionization probability may decrease for increasing field strength. We identify a unique signature for the onset of this dynamical stabilization effect in the photoelectron spectrum.

Journal Article↗
PubMed2005

Density-functional study of interfacial properties of colloid-polymer mixtures.

Interfacial properties of colloid-polymer mixtures are examined within an effective one-component representation, where the polymer degrees of freedom are traced out, leaving a fluid of colloidal particles interacting via polymer-induced depletion forces. Restriction is made to zero-, one-, and two-body effective potentials, and a free energy functional is used that treats colloid excluded volume correlations within Rosenfeld's fundamental measure theory, and depletion-induced attraction within first-order perturbation theory. This functional allows a consistent treatment of both ideal and interacting polymers. The theory is applied to surface properties near a hard wall, to the depletion interaction between two walls, and to the fluid-fluid interface of demixed colloid-polymer mixtures. The results of the present theory compare well with predictions of a fully two-component representation of mixtures of colloids and ideal polymers (the Asakura-Oosawa model) and allow a systematic investigation of the effects of polymer-polymer interactions on interfacial properties. In particular, the wall surface tension is found to be significantly larger for interacting than for ideal polymers, whereas the opposite trend is predicted for the fluid-fluid interfacial tension.

Journal Article↗
PubMed2004

Influence of solvent quality on polymer solutions: a Monte Carlo study of bulk and interfacial properties.

The effect of solvent quality on dilute and semidilute regimes of polymers in solution is studied by means of Monte Carlo simulations. The equation of state, adsorption near a hard wall, wall-polymer surface tension, and effective depletion potential are all calculated as a function of concentration and solvent quality. We find important differences between polymers in good and theta solvents. In the dilute regime, the physical properties for polymers in a theta solvent closely resemble those of ideal polymers. In the semidilute regime, however, significant differences are found.

Journal Article↗
PubMed2003

Coulomb bicrystals of species with identical charge-to-mass ratios.

Structures of cold bicomponent Coulomb systems of particles with identical charge-to-mass ratios and common oscillation frequency in a spherical harmonic potential are studied by molecular dynamics simulations with up to 10(6) particles. For most initial conditions and cooling rates, the final state becomes a completely mixed core surrounded by a set of nearly degenerated double shells of separate species. For an equal amount of the two species, it is found that the ground state for larger systems consists of a simple cubic structured core surrounded by outer double-shell structures.

Journal Article↗
PubMed2003

Nonmonotonic variation with salt concentration of the second virial coefficient in protein solutions.

The osmotic virial coefficient B2 of globular protein solutions is calculated as a function of added salt concentration at fixed pH by computer simulations of the "primitive model." The salt and counterions as well as a discrete charge pattern on the protein surface are explicitly incorporated. For parameters roughly corresponding to lysozyme, we find that B2 first decreases with added salt concentration up to a threshold concentration, then increases to a maximum, and then decreases again upon further raising the ionic strength. Our studies demonstrate that the existence of a discrete charge pattern on the protein surface profoundly influences the effective interactions and that linear and nonlinear Poisson Boltzmann theories fail for large ionic strength. The observed nonmonotonicity of B2 is compared with experiments. Implications for protein crystallization are discussed.

Journal Article↗
PubMed2002

Excitation in ion-atom collisions inside subfemtosecond laser pulses.

We discuss new excitation mechanisms in energetic ion-atom collisions embedded in short laser pulses. For comparable duration and strength of the pulse and collisional interaction, the laser field will probe and modify the interaction between projectile and target. Coherence effects emerge, insight into reaction dynamics is gained, and new dynamical features are discovered. As an example, we show (i) how a propensity rule for s-p excitation can be dramatically changed, and (ii) how the presence of the laser pulse modifies the ionization process in ion-atom collisions.

Journal Article↗
PubMed2001

[Relatives' attitude towards death in hospital].

INTRODUCTION: A survey was conducted over 13 months to measure the satisfaction level of relatives to patients, who had died in hospital. METHODS: The survey contained a questionnaire of 75 questions measuring satisfaction in different areas: the amount and quality of information given to the relatives by doctors, the support and care provided by the staff, and the quality of the physical environment. RESULTS: Out of 619 questionnaires posted, 462 were returned (74.6% response rate). Only half the relatives were satisfied with the level of information given by doctors to themselves and the one dying. Twenty-four per cent of the respondents were dissatisfied by the length of time taken by doctors to inform them about the situation. A broad majority of respondents (85%) were very satisfied with the care and support provided by the nursing staff. Sixty-six per cent of the patients died in private wards. Fifty-five per cent of the relatives were satisfied with the quality of the patient's room, but only 37% were satisfied with the environment offered to them. One in five was especially dissatisfied by the lack of a special room, which would permit enabling private conversations in an undisturbed environment. DISCUSSION: Our survey shows that doctors' communication with the relatives of dying patients needs to be improved. There also seems to be a need for providing a better environment for the relatives of dying patients by reserving separate rooms for rest and conversation.

Attitude to Death↗
PubMed2001

Numerical solution of the Smoluchowski equation for a vibrofluidized granular bed.

A stochastic approach, similar to that used to describe Brownian motion, was used to model the displacement probability of grains in a three-dimensional vibrofluidized granular bed. As neither an analytical description nor measurements of the diffusion coefficients were available, the governing partial differential equation, namely, the Smoluchowski equation, was solved numerically using an iterative procedure, modifying the granular temperature profile at each step. The results of this stochastic model were compared to experimental measurements of the displacement probability density made using positron emission particle tracking. The results indicate that methods based on hard elastic systems such as the Smoluchowski equation are appropriate to granular systems, particularly over timescales greater than the mean collision time.

Journal Article↗
PubMed2001

Many-body interactions and correlations in coarse-grained descriptions of polymer solutions.

We calculate the two-, three-, four-, and five-body (state-independent) effective potentials between the centers of mass (c.m.'s) of self-avoiding walk polymers by Monte Carlo simulations. For full overlap, these coarse-grained n-body interactions oscillate in sign as (-1)(n), and decrease in absolute magnitude with increasing n. We find semiquantitative agreement with a scaling theory, and use this to discuss how the coarse-grained free energy converges when expanded to arbitrary order in the many-body potentials. We also derive effective density dependent two-body potentials that exactly reproduce the pair-correlations between the c.m. of the self avoiding walk polymers. The density dependence of these pair potentials can be largely understood from the effects of the density independent three-body potential. Triplet correlations between the c.m. of the polymers are surprisingly well, but not exactly, described by our coarse-grained effective pair potential picture. In fact, we demonstrate that a pair potential cannot simultaneously reproduce the two- and three-body correlations in a system with many-body interactions. However, the deviations that do occur in our system are very small, and can be explained by the direct influence of three-body potentials.

Journal Article↗
PubMed2001

Treatment of Helicobacter pylori in children with recurrent abdominal pain.

BACKGROUND: The role of Helicobacter pylori remains unclear in children with recurrent abdominal pain (RAP). In this study children with RAP were included in a double blind treatment study to elucidate whether symptoms disappear in children with a H. pylori infection and RAP, if the bacteria are eradicated. METHODS: Thirty-seven H. pylori-infected children aged 4.9-14.5 years (median 9.8 years) with RAP were included. H. pylori was identified by histology and culture. The children were treated with amoxicillin and metronidazole for 14 days. A re-endoscopy including biopsies for histology and culture was done at least one month after the end of treatment. Simple questions for symptoms were asked and blood for serology was repeated 3 and 6 months after the end of treatment. During the observation period the results of the re-endoscopy and the serology 3 and 6 months after the re-endoscopy were blinded for 23 patients and opened to 14 of the patients according to the choice of the families. RESULTS: The eradication rates were 81% (30/37) in the total group and 74% (17/23) in the blinded group. The IgG antibodies to H. pylori decreased significantly 3 (p =.03) as well as 6 months after end of treatment (p <.001) in children with successful eradication. The number of children with RAP decreased after examination and treatment and the well-being improved after 6 months in almost 95% of the children. However, no correlation was seen between eradication of H. pylori and disappearance of RAP, neither after 3 nor after 6 months' observation in the total group of patients (p =.94 and p =.90) or in the blinded group (p =.42 and p =.65). CONCLUSIONS: These results do not provide evidence for a causal relationship between RAP and H. pylori.

Abdominal Pain↗
PubMed2000

Size selectivity of narrow pores.

The selectivity of micropores and ion channels is examined for simple pore topologies within the framework of density functional theory of highly confined fluids. In an infinite cylindrical pore purely steric (excluded volume) effects are shown to lead to strong, nontrivial size selectivity, which is highly sensitive to the pore radius. A crude modeling of electrostatic effects does not alter the relative absorbance of Na+ and K+ ions in a significant way.

Ion Channels↗
PubMed2000

Interobserver variation in diagnosing coeliac disease. A joint study by Danish and Swedish pathologists.

There is an almost 40-fold difference in incidence rates of symptomatic coeliac disease between Denmark and Sweden. In an attempt to explain this difference, the present study focused on the interobserver agreement when pathologists were assessing small intestinal biopsy specimens from children suspected of suffering from coeliac disease. The study was performed on 90 biopsy specimens from 73 children. Most of the biopsies came from children who turned out not to suffer from coeliac disease after a clinical evaluation including small intestinal biopsy. Using the kappa methodology, the interobserver agreement between two Danish pathologists and one Swedish pathologist, all of whom were experienced, was "moderate" to "substantial" or 0.57-0.75. Kappa indices when the pathologists evaluated selected histological elements were in the interval from 0.24 to 0.67. A comparison of a previous routine diagnostic assessment of the 90 biopsies (14 pathologists) with the results of the experienced pathologists in the present study gave kappa indices of from 0.53 to 0.57. The study could prove no major differences in the histopathological assessment of small intestinal biopsy specimens made by Danish and Swedish pathologists. The difference in clinical presentation of coeliac disease in Denmark and Sweden does not relate to differences in the histopathological assessment of small intestinal biopsies.

Adolescent↗
PubMed2000

Effective interactions between electric double layers.

This review summarizes and assesses recent theoretical and experimental advances, with special emphasis on the effective interaction between charge-stabilized colloids, in the bulk or in confined geometries, and on the ambiguities of defining an effective charge of the colloidal particles. Some consideration is given to the often neglected discrete solvent effects.

Journal Article↗
PubMed1999

Self-diffusion of grains in a two-dimensional vibrofluidized bed.

The analogy of vibrofluidized granular beds with a thermal gas of hard discs has been tested. Analysis of the mean squared displacement behavior of the grains allowed comparison of the measured diffusion with the predicted value at a particular combination of granular temperature and packing fraction. High speed photography, image analysis, and particle tracking software enabled accurate location of the grains. Appropriate analysis of the three mean squared displacement regimes, ballistic, diffusive, and crossover between the two extremes, allowed both the diffusion coefficient and the granular temperature to be measured at the same packing fraction. Broad agreement between Chapman-Enskog theory relating temperature to self-diffusion and observation was observed up to packing fractions of eta approximately equal to 0.7. At higher packing fractions the grains showed evidence of caging and jump diffusion, with the observed diffusion rapidly diverging from that predicted by theory. Measurement of self-diffusion coefficients and subsequent use of kinetic theory was found to be an accurate method to determine the granular temperature for intermediate packing fractions (eta=0.4-0.6), and would be particularly suitable for those situations where the time resolution of the experimental facility is insufficient to resolve the speed of the grain between collisions.

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PubMed1999

Plasma-insulator transition of spin-polarized hydrogen.

A mixed classical-quantum density functional theory is used to calculate pair correlations and the free energy of a spin-polarized hydrogen plasma. A transition to an atomic insulator phase is estimated to occur around r(s)=2.5 at T=10(4) K, and a pressure P is approximately equal to 0.5 Mbar. Spin polarization is imposed to prevent the formation of H2 molecules.

Journal Article↗