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Biomedical subjects

J P Gupta

Publications and source records attributed to J P Gupta.

At least 19 recordsLinked to original sources
PubMed1992

Endoscopic sphincterotomy: preliminary experience at a university hospital.

Endoscopic sphincterotomy (ES) was attempted in 38 patients with biliary calculi. There were 21 patients (55.3%) with common bile duct (CBD) stones following cholecystectomy, 14 patients (36.8%) with intact gall bladder and 3 patients with retained CBD stones along with T tube in the early post-operative period. Endoscopic sphincterotomy was possible in all but one patient and duct clearance was attained in 34 (89.4%) patients. Spontaneous clearance of calculi occurred in 31 (81.6%) patients while 3 patients required instrumental extraction. Four patients failed to clear stones and required surgical intervention. Complications occurred in 4 (10.5%) patients--haemorrhage in two, pancreatitis and cholangitis in one each. One patient died of bleeding on the 4th day following ES while hemostasis was achieved in other after two units of blood. Other complications were managed conservatively without any mortality. Endoscopic sphincterotomy appears to be a simple, effective and safe therapeutic modality for the management of biliary calculi.

Adolescent↗
PubMed1991

Heterosis and the lack of coadaptation in Drosophila nasuta.

Natural populations of Drosophila nasuta are polymorphic for several paracentric inversions. Two non-overlapping inversions on the third chromosome (III-2 and III-35) are heterotic in both laboratory and natural populations and display an extreme case of linkage disequilibrium. Intra- and interpopulation crosses involving standard and inverted gene orders of the III-2 and III-35 inversions were made to test if the polygenic complexes within these inversions are coadapted. The inversion heterozygotes formed by the two chromosomes derived from different localities exhibited heterosis since the viability of the heterozygotes was greater than that of either of the two homozygotes. In intrapopulation crosses, the heterozygotes were also heterotic. The present results thus indicated a lack of coadaptation among polygenic complexes within the inversions of D. nasuta. The data suggest that the heterosis produced by these linked inversions is the result of natural selection and epistasis.

Adaptation, Physiological↗
PubMed1990

Chromosomal polymorphism in Indian populations of Drosophila bipectinata Duda.

Drosophila bipectinata, a member of the melanogaster species group, is a common and wide-spread species in the Indian subcontinent. A geographic survey of inversion polymorphism has been carried out in Indian populations. Altogether, nine paracentric inversions are detected in the populations examined during this study. Of the nine inversions, two have been described earlier by Bock from laboratory populations established from Borneo, Thailand and the Philippines. The possible relationship between inversions and different environmental conditions is discussed.

Animals↗
PubMed1990

Autonomic reflexes in borderline hypertensives.

Autonomic reflexes were studied in 53 patients with borderline hypertension (BLH) and 25 normotensives. BLH patients had higher basal heart rate. With 2 minutes of sustained head-up passive tilt of 50 degrees or 75 degrees, the rise in heart rate was comparable in both groups but the rise in blood pressure was significantly more in the BLH group. The rise in systolic pressure with Valsalva manoeuvre as well as with sustained hand grip was significantly higher in BLH patients. The postural tachycardia index and Valsalva index were significantly lower in BLH patients probably due to higher basal heart rate.

Adult↗
PubMed1990

Gastro-esophageal reflux disease (GERD): an appraisal of different tests for diagnosis.

Fifty symptomatic patients with GERD, 20 each of non ulcer dyspepsia (NUD) & duodenal ulcer (DU) and 10 healthy controls were subjected to various tests employed for diagnosis of GERD. Among these endoscopy and histology had highest sensitivities (92% & 91% respectively) followed by Bernstein's test (overall 88%; early positivity 72%) and oesophagography (70%). The specificities of various tests were: endoscopy (86%), histology (82%) and Bernstein's test (overall 80%; early positive 94%). The false positivity was mainly in DU subjects where majority (greater than 84%) had two or more of these tests offitive. Any two of the three tests (endoscopy, histology & Bernstein's test) in combination had a sensitivity of 80-91% and a specificity of 90-92%. Our observations suggest that these tests, particularly in combination, are useful in establishing the diagnosis of GERD and that subclinical oesophagitis in DU might be responsible for the false positivity of these tests.

Adolescent↗
PubMed1990

Serodiagnosis of gut tuberculosis.

The efficacy of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of gut tuberculosis was evaluated. The study included 95 patients with gut tuberculosis, 40 with pulmonary tuberculosis, 25 with non-tubercular intestinal diseases and 40 healthy controls. Mantoux response and antibody titre against PPD using ELISA were studied. The ELISA sensitivity in gut tuberculosis was 80% and in pulmonary tuberculosis 90%. It was also positive in 12% of patients with non-tubercular intestinal diseases and 5% of healthy controls. The sensitivity of Mantoux test in gut (77%) and pulmonary (84%) tuberculosis was comparable to that of ELISA. However, Mantoux test lacked diagnostic significance due to high positivity in non-tubercular disease patients (55%) and healthy controls (56%), whereas ELISA was highly specific (93%) for the diagnosis of gut tuberculosis.

Antibodies, Bacterial↗
PubMed1990

Comparison of stool microscopy and serology (enzyme linked immunosorbent assay) in epidemiology of amebiasis.

Stools from 634 individuals from Varanasi were examined for Entamoeba histolytica (EH). Serology was done in these subjects by enzyme linked immunosorbent assay (ELISA) employing filter paper technique. Stools were positive for EH in 16.9%, and serology in 15.9%. Both the tests were positive in only 5.2%. In 72.4% both the tests were negative. In 11.7% of stool positive cases, serology was negative, and in 10.7% with positive serology stool examination did not reveal EH. A majority (92.5%) of stool positive subjects had only cysts. Additional parasites were detected in 15.3%.

Amebiasis↗
PubMed1990

Neuroticism in patients with irritable bowel syndrome.

Employing a Hindi adaptation of the Middlesex Hospital Questionnaire (MHQ), neuroticism level was assessed in 133 subjects with irritable bowel syndrome and compared with that in patients with organic bowel disease (33), healthy population (140) and known neurotics (110). Compared with healthy controls and patients with organic bowel disease, significantly higher scores were found among irritable bowel syndrome patients in all the subscales except obsession. The total of scores was midway between those of the normal population and known neurotics. Neurotic disorder was detected in 51% of irritable bowel syndrome patients compared to 24% of organic bowel disease subjects (P less than 0.05) and 7.8% of the healthy population. Cut-off points, calculated as mean + 2 SD of scores in the healthy population, were found to be reliable as shown by clinical interview.

Adult↗
PubMed1989

Gene frequencies in natural and laboratory populations of Drosophila nasuta.

Gene arrangement frequencies of different chromosome types of three inversions, IIL-2, III-35 and III-2 are reported in some natural and laboratory populations of Drosophila nasuta. In general, the frequencies of inversion heterozygotes for these inversions are in excess of what is expected under Hardy-Weinberg equilibrium in both natural and laboratory populations. This suggests that these inversion heterozygotes are heterotic to the species as far as viability is concerned. Similar to what occurs in the cosmopolitan species, chromosomes with standard gene sequences are more frequent than inverted gene sequences in this species. The scarcity of inversion homozygotes is due to reduced viability of their carriers, which probably have lethal or sublethal combinations of alleles in the inverted sections of their chromosomes. Further, the inversion frequencies in laboratory populations follow the frequencies in natural populations.

Animals↗
PubMed1989

Medical myotomy for achalasia cardia. Long term results.

Pneumatic dilatation was effective in relieving dysphagia in 16/17 subjects with achalasia cardia. It was also effective and safe in those with sigmoid oesophagus, although dilatation persisted in them. Recurrences were noted in one quarter of cases which were managed satisfactorily with subsequent dilatations. There were no complications. Pneumatic dilatation appears very useful in the management of achalasia cardia.

Adult↗
PubMed1989

Irritable bowel syndrome: therapeutic evaluation of indigenous drugs.

Among 169 patients with irritable bowel syndrome (IBS), standard therapy (with clidinium bromide, chlordiazepoxide and isaphaghulla), a compound Ayurvedic preparation (with Aegle marmelos correa plus Bacopa monniere Linn) along with a matching placebo were given in a double blind randomised trial for 6 wk. The Ayurvedic preparation in 57 patients was found effective in 64.9 per cent, while standard therapy (60 patients) was useful in 78.3 per cent. Patients on placebo (52 patients) showed improvement in 32.7 per cent only. Ayurvedic therapy was particularly beneficial in diarrhoea predominant form as compared to placebo. The standard therapy was more useful in the painful form of IBS as compared to placebo and Ayurvedic preparation. In gas predominant form the effect of standard as well as Ayurvedic therapy, was similar to placebo. Long-term follow-up (greater than 6 months) showed that both forms of therapy were no better than placebo in limiting the relapse.

Adolescent↗
PubMed1989

Efficacy of tinidazole (Fasigyn) in giardiasis by parasitologic, biochemical, and gut transit studies.

Twenty patients (18 M, 2 F; age 16-32 yrs) with symptomatic giardiasis were treated with tinidazole: ten each with a dose of 150 mg twice daily for 7 days, and a single dose of 2 g (50 mg/kg). Stool examination by formalin-ether concentration method was carried out before and one month after treatment. Cure was defined as absence of G lamblia in the stools. Fecal fat excretion (100 g load) and D-xylose absorption (5 g load) were measured before treatment and, if abnormal, repeated one month after treatment. Gut transit time was measured before and one month after treatment by giving radio-opaque beads orally and following their progress fluoroscopically to complete elimination. Parasitologically, all 20 patients were cured. Clinically, there was marked to complete relief of symptoms. Concomitantly, there was significant (p less than 0.01) reduction in fecal fat excretion, improvement in D-xylose absorption, and increase in gut transit time.

Adult↗
PubMed1988

Duodenal tuberculosis.

The clinical and radiological features in 30 cases of duodenal tuberculosis are presented. The patients are divisible into two groups on the basis of their presenting features. Twenty-two had symptoms and signs of gastric or duodenal obstruction, and eight patients had dyspepsia suggesting peptic ulceration. In the first group, laporotomy showed that the duodenal obstruction was due to extrinsic compression by matted tuberculous lymph nodes in the majority; there was only five intrinsic strictures. In patients with dyspepsia there were bulbar and post-bulbar ulcers accompanied by more widespread mucosal changes, induration, and periduodenal lymphadenopathy. Bypass procedures were performed to relieve obstruction; no resection was possible because of the adherence of the lymph node masses.

Adolescent↗