Biomedical subjects

J P Griffith

Publications and source records attributed to J P Griffith.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Structure of a human common cold virus and functional relationship to other picornaviruses.

We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.

Amino Acids↗

PubMedDate not supplied

Esthesioneuroblastoma: an unusual cause of frontal lobe dysfunction.

Esthesioneuroblastoma (olfactory neuroblastoma) is an unusual tumor of neuroectodermal origin, and initial presentation with symptoms characteristic of frontal lobe dysfunction is quite rare. This article describes the case of a patient who was referred to the Charleston Area Medical Center for "depression" but was found to have a esthesioneuroblastoma.

Brain Neoplasms↗

PubMedDate not supplied

Obsessive-compulsive disorder following closed head injury.

Obsessive-compulsive disorder (OCD) is a rare sequelae of closed head injury. Frontal, occipital and fronto-temporal injuries are frequent among reported cases. Response to treatment is often poor. This article describes a patient with OCD and reviews relevant anatomic, neurochemical and psychologic aspects of patients with this condition.

Adolescent↗