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Biomedical subjects

J P Gasnault

Publications and source records attributed to J P Gasnault.

At least 19 recordsLinked to original sources
PubMed1994

[The possible endometrial risk of ovarian stimulation. Apropos of 3 cases].

Three cases of adenomatous hyperplasia of the endometrium--one of them degenerated--have been reported in young women provided with ovulation stimulation. The association between these hormonal therapies and the adenocarcinoma or its antecedents signs, is particularly disturbing. However, it's difficult to establish a relationship between cause and effect. Indeed the women who suffer from an ovarian sterility are a group exposed to a cancer of the endometrium independently of any other iatrogenic agent. The method of detection is yet to be found, as is the mode of conduct which can reconcile the risk of a carcinoma and the desire of pregnancy.

Adenocarcinoma↗
PubMed1993

[From embryogenesis to pathogenesis of effects of diethylstilbestrol on the female genital tract].

From studies on embryogenesis, the authors describe the development, not conditioned by sex steroids, of the upper female genital tract and, in particular, the formation of its cervico-vaginal portion and the shaping of the uterine cervix in about the 16th week of pregnancy. Basing themselves on the physiology of the foeto-placental unit and on the hormonal profile of the foetal ovary, they show that the action of oestrogens on the foetal uterine cervix can be observed only from the 32nd week onward. The action of diethylstilboestrol--a potent oestrogen that is not steroidal and therefore not degraded by foetal metabolism--on the foetal genital tract is explained. An excessive development of the uterine canal caudal part determines structural anomalies of the uterine cervix at birth, the T shape of the uterine cavity and the vaginal diaphragms. The aetiogenesis of clear-cell adenocarcinoma in the cervico-vaginal portion is discussed.

Diethylstilbestrol↗
PubMed1984

[Homologous artificial insemination and male infertility. Study of prognostic factors].

Artificial insemination using the husband's semen (AIH) can help overcome a number of cases of sterility, particularly where these are male in origin. But the results are not always in proportion to the effort required, both from the patients and their doctor. We have compared 25 cases in which AIH resulted in pregnancy with 25 cases in which no pregnancy was achieved after a minimum of 6 cycles' insemination. No factor other than success or failure entered into the selection of cases for comparison. No significant difference was observed in age, past medical history, clinical findings and treatment used. However, study of the seminal analyses showed that the number of spermatozoa was only a secondary factor; sperm motility, and its duration, were more important. This gave two graphs defining two prognostic zones. In 72% of cases, pregnancy was achieved during the first 5 cycles of insemination using AIH. Lastly, miscarriages increased in frequency with age. The number of cases studied is obviously too few to provide any binding statistical conclusions, but these preliminary results give grounds for continuing the study; mathematical models ought to make it possible to identify prognostic factors.

Adult↗
PubMed1983

Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen.

Twenty-five subfertile men, all presenting with idiopathic normogonadotropic oligospermia, were treated with tamoxifen (20 mg/day) for 4 to 12 months. Semen analysis was performed twice before treatment and at least twice after 3 to 12 months of treatment. In 14 patients, serum luteinizing hormone (LH), serum follicle-stimulating hormone (FSH), and plasma testosterone (T) were assayed before treatment, then again after 2 weeks and 12 weeks of treatment. Semen volume, sperm motility, and sperm morphologic characteristics were not modified by tamoxifen. Conversely, a twofold increase of both the mean sperm concentration and the mean total sperm count per ejaculate was observed during treatment (P less than 0.001). Mean values of T, LH, and FSH increased during treatment, but the difference was only significant for T (P less than 0.001) and FSH (P less than 0.05). Ten pregnancies (40% of cases) were reported during the 161 months of treatment.

Adult↗
PubMed1977

[Acute pituitary failure as the presentation of a prolactin cell adenoma during a pregnancy made possible by bromocriptine (author's transl)].

A 21-year-old woman had sterility due to amenorrhoea-galactorrhoea with hyperprolactinaemia and hypoplastic ovaries. The sella turcica was asymmetrical but tomograms were suggestive of a congenital appearance. There was no suprasellar expansion. Treatment with bromocriptine and HMG resulted in pregnancy. Acute pituitary failure occurred at the 10th week, revealing an adenoma. The pregnancy proceeded to term after hypophysectomy. This complication, the first reported under the effects of bromocriptine, may serve as a reminder of the precautions to be taken during pregnancy in a hyperprolactinaemic woman.

Adenoma↗