Efficacy and safety of lamivudine in renal transplant patients with chronic hepatitis B.
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Adult↗
Biomedical subjects
J P Duong
Publications and source records attributed to J P Duong.
Increased TIA1-expressing intraepithelial lymphocytes in cow's milk protein intolerance.
BACKGROUND: Although a high level of intraepithelial lymphocytes (IELs) has been demonstrated in intestinal biopsies from children with cow's milk protein intolerance (CMPI), the properties of IELs in food-sensitive enteropathies remain unclear. In the present study, we analyzed the cytotoxic potential of IELs in CMPI, using a monoclonal antibody directed against the cytotoxic granule-associated protein TIA1. METHODS: The study included 18 duodenal biopsies from 10 children previously diagnosed with CMPI and on a cow's milk-free diet of various duration. Six normal duodenal biopsies from children free of food intolerance served as controls. Immunostaining of formalin-fixed tissues was used to determine in the intraepithelial compartment (1) the number of TIA1-expressing cells per 100 epithelial cells, (2) the number of IELs per 100 epithelial cells, (3) the ratio of TIA1-expressing IELs (TIA1/IEL ratio). RESULTS: In CMPI, the number of IELs and TIA1-positive cells, as well as the TIA1/IEL ratio was significantly increased compared with controls. Moreover, a negative correlation between the TIA1/IEL ratio and the duration of the diet was observed. CONCLUSIONS: These results suggest that the recruitment of IELs with cytotoxic potential is increased in CMPI, and that IEL-mediated cytotoxicity could be involved in the pathogenesis of the disease.
Antibodies, Monoclonal↗
[Cryoglobulinemia].
Cryoglobulinaemias contain seric immunoglobulins which precipitate at low temperatures in some tissues. Based on immunohistochemical analysis of their components (monoclonal or polyclonal), 3 types of cryoglobulinaemias have been identified, and a classification has been proposed. The presence of a paraprotein within the cryoglobulinaemia is due to the proliferation of B cells. Type I is mainly associated with a lymphoproliferative syndrome (myeloma and others...) whereas type II (mixed cryoglobulinaemia) and type III are the result of viral and bacterial infectious diseases, and of autoimmune diseases. Over the last few years, infection by hepatitis C has been found in more than 90% of types II and III cryoglobulinaemias. Cryoprecipitates are pathogenic for kidneys, skin and nervous tissues. In some organs, they are responsible for specific histological lesions, such as necrotizing angeitis with vascular microthrombosis. In kidneys, they occur as endocapillary proliferative glomerulonephrites, accompanied by precipitation of immunoglobulins in the form of intracapillary thrombi. Precipitated immunoglobulins can be identified on frozen specimens. Ultrastructural studies confirm the fibrillar aspect which is characteristic of the cryoprecipitate.
Cryoglobulinemia↗