Biomedical subjects

J P Du Plessis

Publications and source records attributed to J P Du Plessis.

At least 19 recordsLinked to original sources

PubMed1984

Nutritional value of diets of blacks in Ciskei.

This dietary study was part of a nutritional status survey carried out at the request of the Ciskeian Government to provide a baseline from which to formulate a nutrition policy. Nutrient intake was assessed by means of a 24-hour recall of food intake and a diet history, recorded for 750 subjects including children aged 6-23 months, 2-3 years and 7-8 years and lactating women. Nutrient intake was evaluated according to WHO standards. The prevalence of inadequate energy intake was high, especially among the 7-8-year-old children. For all age groups protein represented 11% of total energy intake, but was mainly of low quality. Calcium and iron intakes were low in all age groups, especially in lactating women. For all groups the most deficient vitamin was nicotinic acid, followed by riboflavin and ascorbic acid. This deficiency pattern was the result of a diet consisting predominantly of maize.

Adult↗

PubMed1983

Coronary risk factor screening in three rural communities. The CORIS baseline study.

A three-community study of rural Afrikaans-speaking Whites in the south-western Cape revealed that the major reversible risk factors hypercholesterolaemia, hypertension and smoking, as well as 'minor' factors such as inactivity, obesity, hyperuricaemia, coronary-prone behaviour and the irreversible risk factors of chest pain, ischaemic changes on the ECG and a family history of ischaemic heart disease (IHD), were exceedingly common. Singly or in combination, the major risk factors were present in the great majority of the study population after the age of 44 years. The interaction of high levels of lifestyle-induced risk factors with constitutional predisposition could adequately explain any excess risk of IHD in the Afrikaans-speaking community. The almost universal risk factor prevalence in this study has major implications for any preventive strategy.

Adolescent↗

PubMed1982

Surgical correction of combined supravalvular and valvular aortic stenosis in homozygous familial hypercholesterolaemia.

Although premature coronary atherosclerosis is a well-recognized complication of homozygous familial hypercholesterolaemia, involvement of the aortic root and valve has not been recognized frequently during life. Two cases of supravalvular and valvular aortic stenosis due to familial hypercholesterolaemia are described. Both patients underwent successful surgical correction of these lesions. The importance of relieving left ventricular outflow tract obstruction by a technique of aortic root enhancement and oblique insertion of a prosthesis is stressed.

Aortic Valve↗

PubMed1979

The genesis of amniotic fluid infections.

Amniotic fluid infections manifested by an inflammatory response in the extraplacental membranes and subchorionic plate of the placenta are a common phenomenon thought to be due in most cases to ascending bacterial infections via intact membranes. Fatal spread to the fetus is much less common and more likely to occur in underprivileged communities. The probable reasons are nutritional deprivation in the mother or both, leading to production of a liquor with diminished ability to suppress bacterial growth. Zinc is one component of the antibacterial system but liquor levels of zinc vary widely and inconsistently with antibacterial activity. Dietary supplementation with zinc did not improve antibacterial activity of liquors in a population with diminished liquor antibacterial activity and large number of fatal infections. Other factors in the genesis of amniotic fluid infections may be interference with normal defence mechanisms as a result of coitus in late pregnancy and vaginal infections with Trichomonas vaginalis. Socioeconomic factors may play a role apart from their association with maternal nutrition, through diminished hygiene associated with insufficient use of water and insufficient availability and use of medical facilities.

Amniotic Fluid↗

PubMed1975

Biochemical aspects of a study of 100 obese white subjects.

The effect of a 7 100 kilojoule diet (50% of the energy derived from carbohydrate, mainly unrefined, 30% from fat, mainly unsaturated, and 20% from protein) on 100 overweight subjects was investigated. It was found that 45% of subjects did not complete the study, 9% continued with the study but did not lose weight, 25% lost weight moderately well and 21% responded very well and lost a mean of 15,9 kg over a 6-9 month period. Very little indication of water retention was found. The following biochemical changes occurred during the study period: 1. There was a marked improvement in the glucose tolerance of the groups that lost weight effectively. 2. This improvement in glucose tolerance was associated with a very marked decrease in the secretion of immuno-reactive insulin. 3. The tendency for serum cholesterol and triglyceride levels to decrease during the study was also evidenced in the changes which occurred in the lipoprotein electrophoresis patterns. Stepwise discriminant analysis performed on biochemical, clinical and psychological data failed to provide a practical means of discriminating in advance between the likely response of subjects to this dietary therapy with acceptable accuracy.

Blood Glucose↗

PubMed1974