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Biomedical subjects

J P Demanez

Publications and source records attributed to J P Demanez.

At least 19 recordsLinked to original sources
PubMed1997

Effectiveness of ribosomal fractions of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and the membrane fraction of Kp (Ribomunyl) in the prevention of clinical recurrences of infectious rhinitis. Results of a multicenter double-blind placebo-controlled study.

A multicenter, double-blind, placebo-controlled study was conducted to investigate the efficacy of an immunostimulant, Ribomunyl, in the prevention of recurrences of infectious rhinitis in adults. This trial involved 327 patients (168 Ribomunyl treated and 159 placebo cases) with an average of 4.3 +/- 1.8 rhinitis episodes per patient recorded during the year preceding the study. The main criterion of efficacy was the cumulative number of recurrences of infectious rhinitis during a 6-month follow-up period, as analyzed by standard tests. An additional analysis of relative risk of recurrences used multivariate failure for time data. Ribomunyl was effective throughout the study period, starting from the first month of treatment: a mean of 1.0 +/- 1.1 recurrences was recorded in the Ribomunyl group as compared to 1.5 +/- 1.4 recurrences in the placebo group; this indicated one-third fewer infections (P = 0.001). The protective effect of Ribomunyl on the relative risk for recurrences was estimated to be 0.58 by multivariate analysis (95% CI: 0.43-0.78, P = 0.0001). Analysis of secondary criteria also favored Ribomunyl: 38.5% less antibiotic courses per patient (0.8 +/- 1.3 vs 1.3 +/- 1.6; P = 0.002) and the number of days with antibiotics (5.6 +/- 9.3 vs 9.1 +/- 12.1; P = 0.002).

Adjuvants, Immunologic↗
PubMed1997

Non-Hodgkin's lymphoma of the paranasal sinuses. Report of two cases.

Lymphoma of the paranasal sinuses is relatively rare compared to the occurrence of carcinoma in the same region. The diagnosis is often missed at the early stages of the disease. Two cases of primary extranodal lymphoma of the maxillary sinus are reported. The diagnosis of these malignancies is emphasized.

Aged↗
PubMed1993

[Rhinomanometry].

Bearing in mind the theoretical basis of rhinomanometry, the importance of the nasal air-flow type is underlined. Flow rates, laminar resistance, indications as to the type of nasal flow and value of mixed resistance can be obtained on line by computerized rhinomanometry.

Airway Resistance↗
PubMed1993

[Adenoidectomy].

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Adenoidectomy↗
PubMed1989

[Benign paroxysmal vertigo: comparison of 2 rehabilitation methods].

In case of non-self regression of Benign Paroxysmal Positional Vertigo (BPPV), reeducation is mandatory. Two reeducation protocols have been compared on 32 subjects with BPPV. Fourteen were handled by the classic habituation exercises, and 18 by the more recent Semont's manoeuvre. Moreover a specific rotatory nystagmus habituation has been investigated by caloric stimulation in Brunning III position. Semont's technique shows quicker and more efficient results. This manoeuvre doesn't provoke any habituation, in accordance with the hypothesis of mechanical dispersion of otoconia, based on the cupulolithiasis concept.

Adult↗
PubMed1988

[Optokinetic nystagmus and stimulated visual field. Neuro-otological significance].

In order to study the optokinetic nystagmus of a patient with a possible neurological lesion, it is important to use a stimulating source capable of activating the fovea pursuit system and the peripheral retina system simultaneously. The best stimulating source is that which results in maximum gain and minimum variability of the response, especially if high apparent velocity is used, since in this condition, neither of the two systems is capable of ensuring maximal gain. A comparative study of three modes of stimulation shows that these objectives are attained by the panoramic projection of a familiar painting on which black vertical bands are drawn.

Adult↗
PubMed1987

[Expansive processes of the cerebellopontile angle. Neuro-otological evaluation of 146 cases].

A group of 146 patients with surgically proved C-P angle tumors were studied in respect of the incidence of the trigemino-facial and cochleo-vestibular signs. The particular purpose of this study was to determine the pertinent signs in the early diagnosis of the C-P angle tumor, its stage and histo-pathologic feature's determination. The principal indices of C-P angle tumor are: Wrisberg nerve dysfunction; neural hearing loss as designed by stapedius reflex study and BERA; unilateral vestibular deficit without true and persistent vertigo, first at all when associated with central vestibular signs. The central vestibular syndrome grade, the trigeminal hyposensitivity and the cophose can perform a correction of the stage estimation in 39% when false estimation has been done. Endly, 7 criteria are proposed which help the histopathologic feature differentiation.

Adult↗
PubMed1986

[Electronystagmography aspects of peripheral and central vestibular syndromes].

This report deals with what is to be known in applying ENG in the everyday office. From vestibular, visual and proprioceptive informations central neural processing evolve to stabilize images on the retina. ENG can perform an analysis of these systems, alone or interacting. Anatomical, neurophysiological backgrounds and experimental pathophysiology results are first described. The methodic rule of anamnesis is emphasized and the non instrumental examination is outlined. Concerning the technical aspects and the ENG achievement, some nonlinearities are stressed. Next, procedure of eye movements recording, oculomotor and vestibular testing are described. Alertness, stimulation order, gaze direction and drugs influence the response. The nystagmus responses are evaluated by quantitative parameters and morphological aspects. The variability of these implies the multiplication of the pathological arguments. Peripheral vestibular disturbances lead to labyrinthine paresis or paralysis and to nystagmus directional preponderance, sometimes alone, often combined. Thermic predominance may be associated and cause of some interpretation difficulty. Diagnosis of central neurological disturbances is submitted to four conditions: only specific criteria selection; complete oculomotor and vestibular testing; graduated conclusions in function of the criteria number; no etiological but only functional or topographical diagnosis. Central vestibular syndromes lead also to labyrinthine weakness or nystagmus directional preponderance but, first at all, to specific criteria who are: saccadic, pursuit and horizontal optokinetic abnormalities, central spontaneous or positional nystagmus, failure of fixation suppression, hyperreflexia, perverted nystagmus, slowing of the nystagmus fast phases, slowing-down of the nystagmus slow phases, anisonystagmus, vertical optokinetic deficits and retraction nystagmus. Finally, these dysfunctions incidence in personal observations with some multi or unifocal central pathologies is described and the correspondent more characteristic findings are outlined.

Animals↗
PubMed1986

[Mono-active auditory brainstem evoked response].

We compared, among 30 young subjects, the amplitude of the different BERA's waves, measured with unipolar then direct or indirect bipolar derivations. We brought some new arguments against the theory of a unique BERA's generator. Further, in case the classic derivations are not sufficient, we selected the most convenient derivation for a neurological or audiological diagnostic.

Adult↗
PubMed1981

[The deaf child].

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Audiometry↗