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Biomedical subjects

J P Demanez

Publications and source records attributed to J P Demanez.

At least 19 recordsLinked to original sources

Diagnosis of hearing impairment: factors of delay.

In a retrospective study based on parents' personal interviews, the diagnosis circumstances were analysed in a group of 88 deaf children (moderate to profound deafness). We reported first the age when the parents emitted doubts, and second the age of diagnosis. It appeared that the age of first suspicions, and of diagnosis, was correlated to the degree of deafness. The population of children was divided in two groups depending on the presence of a delay or not in the diagnosis. The first group (24 children) was diagnosed early because of neonatal screening, or of early suspicions by parents or pediatrician. In the second group (64 children) were a delay was observed, seven causes were identified with variable frequency according to the level of deafness. The first four main causes for delayed diagnosis were: 1) parents, 2) medical refutation, 3) otitis media with effusion (OME), 4) progressive hearing loss. In conclusion, the age of diagnosis and the age of first suspicions were too late. Universal neonatal screening is recommended but do not appear to be the exclusive procedure to reduce the diagnostic's delay. This analysis of the factors of delay, prompted us to recommend: 1) information to parents on deafness, 2) careful attention to parents suspicions, 3) an objective evaluation of auditory function,especially after OME cure and 4) a follow-up of children to identify progressive hearing loss.

Age Factors↗

[Central auditory processing assessment].

OBJECTIVE: A battery of tests for central auditory processing assessment has been designed in French. This battery, BAC for Bilan Auditif Central (central auditory processing), consists of'fbur tyvpes of tests: A speech-in-noise test, a dichotic test, a temporal processing test and a binaural interaction test. MATERIAL AND METHOD: Descriptive statistics were computed on data obtained from 668 subjects ranging from 5 to 85 years old. RESULTS: Tests scores of the speech-in-noise test, the dichotic test and the binaural interaction test showed a normal distribution. Test scores of the temporal processing demonstrates a ceiling effect. Effcts of maturation and involution were clearly visible for all tests. CONCLUSION: The low correlation between scores obtained from the four tests pointed to the need for a battery ofseveral tests to assess central auditory processing.

Adolescent↗

Anatomophysiology of the central auditory nervous system: basic concepts.

The purpose of this review is to provide an overview of the central auditory nervous system (CANS). Three main relay nuclei are located between the auditory nerve and the primary auditory cerebral cortex: 1- the cochlear nucleus, 2- the contralateral inferior colliculus and 3- the contralateral medial geniculate body. Some fibers of this main ascending pathway branch off to other nuclei such as the nuclei of the superior olivary complex and the nucleus of the lateral lemniscus. Fiber tracts connect the two sides of the ascending pathway at several levels, in such a manner that each ear projects heavier to the contralateral temporal cortex. As sensory information travels within the CANS, its processing occurs not only in a serial order but also in a parallel manner resulting a highly efficient and redundant system. Finally, this review put forth a model of central auditory processing that can serve as the basis for evaluating and addressing the needs of eventual revalidation.

Auditory Cortex↗

Central auditory processing assessment.

As the acoustic information travels within the central auditory nervous system, the processing of the signal undergoes several levels of serial and parallel "bottom-up" processing influenced by high level cognitive "top-down" processes. Because the multiple location of the operational sites, the central auditory deficits are frequently quite subtle and need a test battery approach to be identified. Each of the four principal processes has at least to be tested: the closure task, the dichotic ability, the temporal ordering task and the binaural interaction function. The purpose of this review is to provide an overview of the psychoacoustic test procedures of identifying lesions or dysfunction's in the central auditory system.

Audiometry↗

Central auditory processing assessment: a French-speaking battery.

Based on the American Speech-Language-Hearing Association (ASHA) Consensus Statement on central auditory processing and models for their exploration, a battery of audiological tests (Bilan Auditif Central--BAC) has been designed in French. The BAC consists of four types of psycho-acoustic tests: a speech-in-noise test, a dichotic test, a temporal processing test and a binaural interaction test. We briefly describe the rationale of these tests. The BAC is available in digital format. Descriptive statistics were computed on data obtained from 668 subjects divided into 15 age-groups ranging from 5 to 85 years old or over. All subjects had no complaints regarding hearing loss, normal tonal audiometry, and normal intelligence. Tests scores of the speech-in-noise test, the dichotic test and the binaural interaction test showed a normal distribution. Test scores of the temporal processing test did not follow a normal distribution. Effects of maturation and involution were clearly visible for all tests. The low correlation between scores obtained from the four tests pointed to the need for a battery of several tests to assess central auditory processing. We claim that the reported scores represent standard norms for the normal French-speaking population, and believe that the tests will be useful for evaluation of central auditory processing.

Adolescent↗

Central auditory processing disorders: some cohorts studies.

This paper presents an overview of the use of a French-speaking battery for the assessment of a central auditory processing disorder (CAPD) in a variety of clinical populations: prematurely born children; 8 years old children who had otitis media with effusion in early infancy; children with learning problems and dyslexia; French-speaking children attending Dutch and English schools; adults with King-Kopetzky syndrome and elderly hearing aids users. Population characteristics of each of these groups are presented and discussed.

Adolescent↗

Surgery of inverted papillomas under endoscopic control.

Six centers cooperated in a retrospective study on endoscopic surgical resection of Papillomas of the nose and paranasal sinuses in order to assess both the efficiency and the safety of this kind of surgical approach. From 1991 till march 2000, 87 cases of Papillomas resections under--at least partially--endoscopic control were gathered, among which 85 were Inverted Papillomas (IP), 2 were Exophytic Papilloma (EP) and one was IP coexisting with Collumnar Cell Papilloma (CCP). Malignant transformation was found out in 3 cases of IP. Regarding the 85 patients with IP demographics are as follows: 61 males, 24 females, with a mean age of 58.4 years (STDV: 13.96) in a range from 27 to 92 years. The mean follow-up was of 41.9 months with range of 1-120 months. Fifteen recurrences occurred that were treated by revision surgery either under endoscopic control or by limited external approach. The mean time for recurrences to occur was 8.07 months with range of 1-24 months. The three patients with malignant transformation underwent postoperative radiation therapy. All of the patients are free of recurrence, however for some of them the follow-up is too short to definitely assess their free of disease status. The role of modern diagnostic tools in medical imaging--CAT and MRI--in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The stress is put on the need for radical excision under endoscopic control which can be combined with the Caldwell-Luc transantral approach or with frontal trepanation for the cure of tumors impossible to be reached under endoscopic control only. Irrespective of the tumor extent and of the approaches that was used for excision a close endoscopic follow-up still remain mandatory, by trained surgeons, in the long term management of IP. Biopsies, CAT and/or MRI must be performed in any case with recurrence suspicion.

Adult↗

[Cochlear implants].

A cochlear implant is a technologically advanced medical device that simulates sound in the cochlea by electrically stimulating the hearing nerve. Cochlear implants are designed to help severely or totally deaf individuals who gain little or no benefit from hearing aids. Hearing aids and assistive listening devices amplify sounds. The sounds produced by even the most sophisticated hearing aids may not offer much benefit to people with a severe-to-profound or profound hearing loss in both ears. A cochlear implant is an electronic device that provides the function of the damaged or absent hair cells by providing electrical stimulation to the remaining nerve fibers. The implant provides useful hearing and improved communication abilities to the implant user.

Adult↗

[Halitosis: a multidisciplinary problem].

Bad breath, or halitosis, affects between 50 and 65% of the population. Despite its frequency, this problem is often unaccepted and declared taboo. In about 8% of the cases, bad breath is related to an ENT pathology (sinusitis, tonsillitis, ...). More rarely it is caused by a metabolic (diabetes, trimethylaminuremia, ...) or gastric dysfunction. Ninety percent of the cases however, are associated to an oral disease: either gingivitis due to an inadequate removal of dental plaque, especially from interdental spaces, or periodontitis (alveolar bone destruction), or bacterial accumulation on the dorsum of the tongue. In most cases, an intensive disinfection of the mouth by scaling and root planing and/or instruction of a perfect oral hygiene will be sufficient to solve the problem. Perfumed mouthwashes or toothpastes will only give a short-term masking effect. An effective collaboration between a dentist or a periodontist and an ENT specialist is of great importance to dealt with bad breath.

Circadian Rhythm↗

[Nasal obstruction. Physiology, etiology and review].

Nasal obstruction is a major epidemiologic medical problem. The cost of its medical and surgical treatment is considerable. The frequency of the symptoms and their usual benign course often lead the physician to pay little attention to them. Occasionally, life-threatening problems, such as Wegener's granulomatosis may first present as nasal obstruction. Frequently, nasal obstruction deteriorates the quality of life by causing serious discomfort and by altering with the sense of smell and taste.

Airway Resistance↗

Effectiveness of ribosomal fractions of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and the membrane fraction of Kp (Ribomunyl) in the prevention of clinical recurrences of infectious rhinitis. Results of a multicenter double-blind placebo-controlled study.

A multicenter, double-blind, placebo-controlled study was conducted to investigate the efficacy of an immunostimulant, Ribomunyl, in the prevention of recurrences of infectious rhinitis in adults. This trial involved 327 patients (168 Ribomunyl treated and 159 placebo cases) with an average of 4.3 +/- 1.8 rhinitis episodes per patient recorded during the year preceding the study. The main criterion of efficacy was the cumulative number of recurrences of infectious rhinitis during a 6-month follow-up period, as analyzed by standard tests. An additional analysis of relative risk of recurrences used multivariate failure for time data. Ribomunyl was effective throughout the study period, starting from the first month of treatment: a mean of 1.0 +/- 1.1 recurrences was recorded in the Ribomunyl group as compared to 1.5 +/- 1.4 recurrences in the placebo group; this indicated one-third fewer infections (P = 0.001). The protective effect of Ribomunyl on the relative risk for recurrences was estimated to be 0.58 by multivariate analysis (95% CI: 0.43-0.78, P = 0.0001). Analysis of secondary criteria also favored Ribomunyl: 38.5% less antibiotic courses per patient (0.8 +/- 1.3 vs 1.3 +/- 1.6; P = 0.002) and the number of days with antibiotics (5.6 +/- 9.3 vs 9.1 +/- 12.1; P = 0.002).

Adjuvants, Immunologic↗

Non-Hodgkin's lymphoma of the paranasal sinuses. Report of two cases.

Lymphoma of the paranasal sinuses is relatively rare compared to the occurrence of carcinoma in the same region. The diagnosis is often missed at the early stages of the disease. Two cases of primary extranodal lymphoma of the maxillary sinus are reported. The diagnosis of these malignancies is emphasized.

Aged↗

[Rhinomanometry].

Bearing in mind the theoretical basis of rhinomanometry, the importance of the nasal air-flow type is underlined. Flow rates, laminar resistance, indications as to the type of nasal flow and value of mixed resistance can be obtained on line by computerized rhinomanometry.

Airway Resistance↗

[Adenoidectomy].

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Adenoidectomy↗