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Biomedical subjects

J P Castel

Publications and source records attributed to J P Castel.

At least 37 records · Page 2Linked to original sources

[Clinical, neuroradiologic and developmental aspects of idiopathic benign subarachnoid hemorrhage (subarachnoid hemorrhage of unknown cause). Retrospective study of 65 cases].

Sixty-five patients with a mean age of 50.2 +/- 10.9 were admitted with a subarachnoid hemorrhage and a subsequent normal cerebral panangiography. On admission, 69% of the patients were graded I or II on the Hunt and Hess scale, versus 14% of them admitted on grade IV or V. Fifty-one patients (78%) were submitted to a second angiography between day 10 and day 132 after their hemorrhage (average day 29). A third angiography was performed on twenty-six patients (40%). Angiographic vasospasm was present on 52% of the first angiograms and affected predominantly the vertebro-basilar arterial system. On the second angiography, the vasospasm was still present on 26 out of 32 angiograms performed before day 30, and was only noted on 2 out of 19 angiograms performed later. No rebleeding was recorded in this group of patients who were followed-up for an average of 49 +/- 23 months. Complication as acute hydrocephalus affected 17% of the patients. In two patients (3%), symptomatic vasospasm was judged responsible of a delayed neurological deficit with concomitant hypodensity on the CT scan. Angiographic explorations were complicated by a transient ischemic deficit in 3 cases and by a fatal stroke in one case (4 cases out of 65 procedures, or 6%). As another patient died with bronchopneumonia during the hospitalization, the initial mortality rate was 3%. During the period of follow-up, two patients died from medical causes unrelated to their initial hemorrhage. Finally, 92% of the patients were alive and in an excellent or good clinical condition.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[Cavernous angioma of the optic chiasm].

A case of an hemorrhagic cavernous hemangioma of the optic chiasma and the adjacent optic nerve in a 23-year-old woman is reported. The visual disturbance has subacute onset following a sudden lateralized headache. Through a fronto-pterional approach, an intrachiasmal hematoma was evacuated. A small cavernous hemangioma was found in the hematoma cavity, and it was totally removed. Visual symptoms improved slightly postoperatively. Cavernous hemangioma involving the optic nerve and chiasma is extremely rare. Only five similar cases have been reported previously.

Adult↗

[Exploratory strategy for hydrocephalus in adults].

Decision theory can be useful for the determination of an optimal diagnostic and/or therapeutic strategy. Of course, the physician remains the only decision-maker, but these methods, quite simple, introduce a scientific background to medical decisions by the quantitative evaluation of the consequences of the choices. We will present the use of such a methodology in the treatment of adults presenting hydrocephalus.

Adult↗

Cerebrospinal shunt flow in adults: radionuclide quantitation with emphasis on patient position.

Radionuclide quantitation of cerebrospinal fluid (CSF) flow through a ventricular shunt using a Cordis-Hakim valve was performed in 78 adults (138 studies). All remained supine for at least two hours before the study to avoid possible depletion of ventricular CSF. The absolute flow rate distinguished shunt adequacy from patency by defining flow of less than 0.1 ml/min. as abnormal. Measurements were performed with the patient first supine and then erect. When abnormal supine flow was the criterion of malfunction, all obstructions were detected but there were 6 false positives. When abnormal erect flow was considered, there were 5 false negatives. Abnormal flow in both supine and erect positions is a reliable indication of malfunction. The authors conclude that this technique is valuable for neurosurgical management of ventricular shunts.

Adolescent↗

[Severe ventricular arrhythmia following parenteral administration of vincamine. Predisposing factors in 6 cases].

Six patients developed ventricular arrhythmias with parenteral administration of vincamine. Direct intravenous injection was the mode of administration in 2 cases, intravenous infusion in 3 cases (one at very high dosage) and intramuscular injection in 1 case. The same signs of toxicity were observed in al patients:--5 patients had recorded attacks of "torsades de pointe", which recurred in 1 of them when the drug was restarted.--1 patient had syncope and, although an ECG was not recorded at the time, an ECG shortly afterwards showed a long QT interval and R/T ventricular extrasystoles. Symptoms were generally neurological in nature with syncope, cyanosis, and convulsions. Spontaneous regression was observed in 3 cases but in the others the drug had to be stopped and cardiopulmonary resuscitation instituted. None of our patients died of their arrhythmia. In some patients a predisposing factor was found:--metabolic: hypokalaemia (1 case), moderate reduction of potassium pool (1 case), severe reduction of calcium pool (1 case);--pharmacological: previous treatment with fenoxidil (1 case), thioridazine (1 case);--cardiac: congenital long QT interval (Romano-Ward) (1 case), revealed by vincamine administration. Chronic obstructive airways disease with right ventricular strain and atrial fibrillation (1 case) which might have predisposed the patient to "torsades de pointes". Three patients had no predisposing factors apart from their age. "Torsades de pointes" occurred in a pacemaker patient, but pacemaker function was normal. These six cases may be grouped with the other ten or so cases of vincamine toxicity already reported; they carry and additional warning on the use of intramuscular vincamine. Vincamine toxicity is probably a direct effect on the myocardial cells. This fact merits verification by further electrophysiological studies.

Aged↗

[Study on a mock cerebro-spinal fluid (author's transl)].

The work presented was initiated in order to evaluate the biological and clinical tolerance of the isotonic saline solution (9 p. mille) usually used in neuro-surgery directly in contact with the nervous tissue in comparison with a new solution proposed as a a mock cerebrospinal fluid. Clinically, two patient' populations including 75 patients each, were compared during dynamic investigation of intracranial pressure with intra-ventricular injections of different solutions. The effects of prolonged intra-ventricular perfusion with each solution were studied in animal models by: --electrophysiological analysis of EEG activity during perfusion --morphological observation: electronic microscopy of different cerebral structures after the perfusion. The biological tolerance was analyzed by the use of routine tissue culture of CNS tissue exposed to the two solutions. The results obtained show the toxicity of isotonic saline solution (9 p. mille) and the perfect tolerance of S.21.001 solution as a mock cerebro-spinal fluid.

Animals↗