Mapping recognition memory in the primate brain: why it's sometimes right to be wrong.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
J P Aggleton
Publications and source records attributed to J P Aggleton.
The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia.
The relationship between the anterograde amnesic syndromes associated with diencephalic and temporal lobe pathology is examined in the light of recent findings. It is proposed that a common feature of anterograde amnesia is damage to part of an "extended hippocampal system" comprising the hippocampus, the fornix, the mammillary bodies, and the anterior thalamic nuclei. Damage to this system results in deficits in the recall of episodic information, the core symptom of anterograde amnesia. In contrast, lesions in this system need not disrupt tests of recognition memory when they primarily tax familiarity judgements. It is assumed that familiarity judgements depend on other regions (e.g. the rhinal cortex in the case of temporal lobe amnesia) and that the extended hippocampal system is principally involved in those aspects of recognition that are retrieval-based rather than familiarity-based. These proposals arise from new evidence on the performance of delayed nonmatching-to-sample by animals, from a meta-analysis of the performance of amnesic subjects on a test of recognition memory, and from new research into the pattern of connections between the medial temporal lobe and the medial diencephalon in primates.
Amnesia↗
Handedness and longevity: archival study of cricketers.
OBJECTIVE: To test whether handedness is associated with a change in longevity. DESIGN: Archival survey. SETTING: British Isles. SUBJECTS: All first class cricketers born before 1961 whose bowling hand was specified (right, n = 5041; left, n = 1132) in a comprehensive encyclopaedia. MAIN OUTCOME MEASURES: Bowling hand and life span. RESULTS: Regression analysis of the 5960 players born between 1840 and 1960 (3387 dead, 2573 alive) showed no significant relation between mortality and handedness (P = 0.3). Left handedness was, however, associated with an increased likelihood of death from unnatural causes (P = 0.03, log hazard 0.37, 95% confidence interval 0.04 to 0.70). This effect was especially related to deaths during warfare (P = 0.009, log hazard 0.53, 0.13 to 0.92). CONCLUSION: Left handedness is not, in general, associated with an increase in mortality.
Cause of Death↗