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Biomedical subjects

J Ovseyevitz

Publications and source records attributed to J Ovseyevitz.

34 records · Page 2Linked to original sources

[Tetralogy of Fallot associated with supravalvular mitral membrane].

Two children with tetralogy of Fallot and supravalvular mitral membrane are reported. In both, the diagnosis was established before surgery. In the first case, clinical data suggested the associated mitral lesion and a two-dimensional echocardiogram demonstrated a supravalvular membrane. In the second patient, mitral obstruction was diagnosed by Doppler echocardiography and the supravalvular membrane was visualized by means of the angiographic study. Despite the rare association of both malformation, the importance of its clinical recognition is mainly related to the surgical correction of both lesions.

Child, Preschool↗

[Anti-rubella IgM and IgG antibodies in congenital cardiopathy].

In utero infection by rubella virus is a well known cause of congenital heart disease. We look for prevalence of anti-rubella antibodies of IgM (primary response) or IgG (anamnestic response) classes in sera of 32 children with congenital heart disease and in 12 normal children of the same socioeconomic background. Only in a patient with a full congenital rubella syndrome we found high titers of IgG anti-rubella antibodies, there was no difference in prevalence of IgM nor IgG anti-rubella antibodies between normals and cardiac patients. There is no reason to look for anti-rubella antibodies in the isolated congenital heart disease.

Antibodies, Viral↗

[Corrected transposition of great arteries. Surgical results].

Thirteen patients with congenitally corrected transposition of the great arteries underwent cardiac surgery between May 1964 and May 1984. Eleven cases underwent corrective surgery and two palliative treatment. Four cases had closure of the ventricular septal defect two had pulmonary valvotomy, two closure of atrial septal defect and three tricuspid valve replacement. Two patients developed atrioventricular dissociation, requiring pacemaker insertion. Two patients died, one in the immediate postoperative period in pulmonary edema, and another due to bacterial endocarditis 3 years after surgery. Our observations suggest that surgical treatment of corrected transposition can be achieved with acceptable risks. The long-term follow up in the survivors was excellent.

Adolescent↗

[Natural history and surgical treatment of pulmonary stenosis. Review of 91 cases].

The natural history of valvular pulmonary stenosis is modified by the surgical treatment of these patients. In order to assess these changes we studied the clinical and hemodynamic features of 91 patients that were treated surgically. Hemodynamic studies were performed postoperatively in 62 of them. All patients had preoperatively a right ventricular systolic pressure above 70 mm Hg and were divided into three groups according to the transvalvular gradient. The first group had less than 50 mm Hg, the second group between 50 and 80 mm Hg, and the third group more than 80 mm Hg gradient. Correlation of these values with asymptomatic (49 patients) and with symptomatic (42 patients) cases showed significant values (p less than 0.001). Postoperatively only 2 patients remained with mild degree effort dyspnea. There was also a significant correlation (p less than 0.005) between the systolic gradient and the cardiothoracic ratio in the studied groups. The T wave in lead VF showed a predictive value in relation to the systolic gradient (p less than 0.001). Reduction of the systolic gradient after surgery showed very significant values when compared to the preoperative gradient (p less than 0.001). The overall mortality was 5.5%.

Adolescent↗

[Echocardiographic signs of congenital absence of the pulmonary semilunar cusps].

Five patients with congenital absence of the pulmonary valve leaflets were studied with M-mode and two-dimensional echocardiography. In addition to previously reported findings in this heart malformation, we found the presence of a narrow valvular ring that obstructs the outflow tract of the right ventricle, and a to-and-fro movement of the contrast bubbles from the right ventricle to the pulmonary artery suggesting pulmonary regurgitation. These features along with the volume overload data of the right ventricle suggests the diagnosis of congenital absence of the pulmonary valve leaflets.

Adolescent↗

[Double-outlet left ventricle].

Two cases of double-outlet left ventricle with ventricular septal defects and pulmonic stenosis are described. Both had atrial situs solitus, one with concordant and another with discordant atrioventricular connections. Considering the clinical behaviour of the malformation, the diagnosis is difficult. Although the echocardiographic findings suggest the abnormality, angiocardiography is the best procedure for the accurate diagnosis.

Angiocardiography↗

[Axial angiography in tetralogy of Fallot].

We studied 15 patients with the diagnosis of tetralogy of Fallot by means of conventional and axial angiocardiography. Axial studies were performed in the four chamber view (vertical and horizontal X-ray beams) and in the sitting-up view (vertical X-ray beam). With the right ventriculogram we analyzed the anatomic characteristics of this chamber, infundibular stenosis and the pulmonary branches. Left ventriculograms were performed in order to rule out other less common associated defects. In the sitting-up view we analyzed the characteristics of the right ventricular infundibulum and the pulmonary valve, artery and branches. None of our patients underwent aortography or coronary artery angiography. We conclude that utilization of axial angiocardiography is useful in tetralogy of Fallot because it permits a better appreciation of the anatomy of this malformation, the presence or absence of stenosis of the pulmonary branches and other less frequent associated defects. Aortography or coronary artery angiography must be performed in children in which the anatomy of the coronary arteries cannot be determined by either left or right ventriculograms.

Angiocardiography↗

[Fibrous fixed subaortic stenosis].

Fifty eight patients with isolated with discrete subaortic stenosis or in association with just another heart defect, were studied between 1961 and 1980. The age range was between 2 and 42 years. The evaluation of each case was done according to clinical manifestations, systolic overloading of the left ventricle and the amount of the systolic gradient. There is a poor correlation between the clinical, electrocardiographic and hemodynamic parameters according to the student t test in the preoperative evaluation. Forty-one patients were operated, two of them died in the early post-operative period. There was a good clinical evolution with significant values comparing pre and post-operative symptoms. The decrease in the systolic gradient in 26 cases after surgery was significative (p less than or equal to 0.005). Based on the natural history of this malformation and on the results obtained with the surgical treatment, we may conclude that there is surgical indication once the diagnosis is made, because this malformation has a completely different evolution compared with other forms of congenital aortic stenosis.

Adolescent↗

[Infectious endocarditis in children].

he recent advances in surgical treatment of congenital heart disease, permits the survival of those cases to adult life. Infective endocarditis in the childhood is becoming increasingly important. We studied 32 cases in the pediatric cardiology ward at the INC between 1977 and 1981. There was a male predominance of 62.5%. Rheumatic heart disease (40.7%), congenital heart disease (15.6%) and postoperative cases (43.7%) were the underlying conditions. There was an average time of 43 days delay from the first symptom to diagnosis. Blood cultures were taken in 29 cases (90.6%). Only half of them were positive. Staphylococcus and streptococcus were the commonest isolates. Peripheral and pulmonary embolism (11 cases-34.4%) were the most frequent complications. In those cases with negative blood culture the most successful antibiotic combination was ampicillin or oxacillin plus aminoglucosides (56%). There were 17 deaths (53%).

Adolescent↗

[Superoinferior ventricles].

We describe two patients with under-and-over ventricles. Both were diagnosed angiographically. One has atrial, situs solitus with discordant atrioventricular and ventriculoarterial connections and a ventricular septal defect. The second has atrial situs inversus with concordant atrioventricular connections and double-outlet right ventricle. We review the literature and analyze the probable embryogenesis of the malformation.

Adult↗

[Echocardiographic study of different forms of pulmonary atresia].

Echocardiographic recognition of pulmonary atresia with either ventricular septal defect or intact ventricular septum is of great value in the differential diagnosis with other forms of right ventricular outflow tract obstruction or hypoplasia of the right ventricle. We studied nine patients with pulmonary atresia seven with ventricular septal defect and two with intact ventricular septum. It was not possible in either group of these patients to register systolic opening and diastolic closure movements of the pulmonary valve. In the group with ventricular septal defect, aortic straddling was present in all cases. In one patient it was possible to register the echoes of an imperforated pulmonary valve. In the remaining patients, the differential diagnosis with persistent truncus arteriosus was not possible. M-mode and Two-dimensional echocardiographic features of pulmonary atresia with intact ventricular septum are specific of this malformation and can differentiate it from other forms of hypoplasia of the right ventricle.

Child↗

[Anatomy of atrioventricular discordances].

Nineteen anatomic specimens were revised, 10 in situs solitus and 9 in situs inversus. The type of atrioventricular connection, atrioventricular relation, the characteristics of atrioventricular valves and ventricular cavities, the atrial and ventricular septa, the conducting tissue, the type of arterio-ventricular connections, the anatomy of the coronary arteries and associated defects were studied. The anatomic features of the ventricular cavities differ from those in the normal heart with respect to the orientation of the atrio-ventricular valve rings, the implantation of the papillary muscles in both ventricles and the extention of the membranous septum. The most frequently found type of arterioventricular connection was discordant, followed by double-outlet right ventricle, concordant connections and finally single outlet. We did not find any case of double-outlet left ventricle. It is important to know the anatomy of the conducting tissue that is in close contact with the ventricular septal defects, the most common associated anomaly in our series, and with infundibular pulmonary stenosis.

Heart Atria↗

[Congenital abnormalities of the tricuspid valve and Ebstein's anomaly with pulmonary valvular stenosis].

We are reporting a case of Ebstein's anomaly of the tricuspid valve and another case of a congenital double tricuspid lesion, both associated with pulmonary valve stenosis and with similar hemodynamics and physiopathology. Given that there are few reported cases in the literature, we analyzed the clinical and electrocardiographic findings of both. The utility of the echocardiogram is discussed in the diagnosis of such abnormalities and the angiographic and hemodynamic data commented upon. It is emphasized that right ventricular hypertension (105 mm Hg, and 98 mmHg, respectively) modifies the cardiopathic hemodynamics and its natural history, that was favorably modified by isolated corrective surgery of the pulmonary obstruction. The postoperatory transvalvular gradients were measured at 27 and 11 mm Hg, respectively. After having revised the pertinent bibliographic literature, we commented upon the factors that give such a high mortality rate in Ebstein's surgery and the congenital abnormalities which are most frequently associated.

Child↗

[Isolated hypoplasia of the right ventricle].

Four cases of hypoplastic right ventricle with intact ventricular septum are presented. All of them were diagnosed by means of an angiographic study, and one case was examined postmortem. The anatomic, physiologic and clinical features of this malformation are analyzed and the differential diagnosis with similar congenital cardiac diseases is discussed.

Adolescent↗

[Pulmonary atresia with intact interventricular septum].

Ten cases with pumonary atresia with intact interventricular septum were studied; they were divided in type I (6 cases) and type II (4 cases). In the cases with necropsy no distinct characteristics were observed in comparison to those reported in the literature. Cyanosis, heart failure, cardiomegaly and pulmonary oligohaemia were present in all cases. No correlation was found neither between right atrial middle pressure and the P wave amplitude (r = 0.014), nor between the AQRS and the right ventricular systolic pressure (r = 0.039). All the cases from type II showed hypertrophy of the two ventricles and only one case from type I showed right ventricular hypertrophy. In nine cases right ventricular hypertension was registered. Right atrial middle pressure and right ventricular telediastolic pressure were found increased in nine cases; the other one showed normal values (type II). The angiocardiographic study is a necessary diagnostic procedure. By means of it is possible to determine the ventricular cavity size, the right ventricular infundibulum characteristics and the atresic segment size.

Arteriovenous Malformations↗