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Biomedical subjects

J Otto

Publications and source records attributed to J Otto.

At least 127 records · Page 7Linked to original sources
PubMed1977

[Results of objective accommodation determination in eyes with alternating functional central scotoma (alternating strabismus) (author's transl)].

Objective determination of monocular accommodation in young eyes revealed a different behaviour in strabismus alternans from that in normal binocular vision. This manifested itself by strongly differing individual responses, less correct values in physiological and unphysiological accommodation tests, and different reactions on hindering clear vision that cannot be compensated by refraction changes. The possibility of central scotoma, persisting during fixation and varying in density, occurring in alternating strabismus, is discussed.

Accommodation, Ocular↗
PubMed1977

Electrical stimulation in chronic low-back pain.

Since 1972, 367 patients with chronic low-back pain have been treated by electrical stimulation (e.s.). Patients with herniated disc lesions and spondylitis and allied conditions were included. Following e.s. 75-100% pain relief was obtained by 53% of the patients 50% pain relief by 27% and there was no improvement in 20% of patients. In a follow-up of 208 patients, 6-36 months later, approximately 70% stated that pain relief was similar to that obtained at the end of treatment.

Back Pain↗
PubMed1977

Radioimmunoassay for porcine lipotrophic peptide B.

A sensitive radioimmunoassay for the lipolytic peptide B from pig pituitary glands has been developed. Antisera were raised in rabbits, which allowed a final dilution of 1:6000. Free and antibody bound [125I]peptide B could be separated by double antibody, by dextran-coated charcoal and by polyethyleneglycol. The smallest detectable amount was 0.5 ng/ml. Peptide B could be measured irregularly in porcine sera; there was cross-reacting material in an extract of a total human pituitary gland, but not in human sera. The assay seems specific except for a strong cross-reaction with porcine neurophysin. There are indications that peptide B consists of neurophysin and a small lipolytically active peptide which remains to be further characterized.

Animals↗
PubMed1976

[Pharmacological investigations of 4'-fluoro-4-(4-methyl-peperidono)-butyrophenone with respect to its sedative and sleep-inducing properties (author's transl)].

The butyrophenone melperone (Eunerpan) in mice and rats caused a prominetn inhibition of spontaneous activity, whereas cataleptogenic and apomorphine-antagonistic properties were less pronounced. In rats the sleep-cycle was altered: decrease of wakefulness, increase of slow-wave sleep and a moderate reduction of rapid eye movement-(REM) sleep. In contrast to thioridazine and chlorpromazine the effect lasted only for 4 h, followed by a slight REM rebound. In rabbits melperone caused a decrease of muscle tone and with somewhat higher doses an inhibition of the arousal-reaction. As seen by the computerized spontaneous cortical EEG, dosages below 1 mg/kg caused a shift of the dominant frequency from theta- to delta-rhythm and an increase of power. Therefore the neuropharmacological pattern of the butyrophenone melperone is closely related to those of thioridazine or chlorpromazine, without, however, having their long action.

Animals↗
PubMed1976

[Objective determination of the consensual accommodation (author's transl)].

The direct and consensual accommodation of both eyes were determined by a modified coincidence refractometer. Young individuals with normal monocular and binocular vision revealed a close quantitative correspondence between the direct and the ipsi- and contralateral consensual accommodation. Experimental impairment of the function of the ciliary muscle by medical means caused disturbed consensual accommodation of both eyes. The weakening of the function of the ciliary muscle of one eye by instillation of, for example Homatropin leads to an important increase of the contralateral and diminution of the ipsilateral consensual accommodation. By the results of the investigations it was concluded: 1. that the regulation of the direct accommodation reflex is influenced also by the function of the ciliary muscle in the fixating eye and has stimulating and depressing components, 2. that the innervation of the nonfixating eye passes through an efferent neuron, from where the accommodation impulse emerges to both eyes. - The anatomically based relation between the direct and the ipsilateral and contralateral consensual accommodation allows one to use its quantitative determination in both eyes as a diagnostic test in afferent and efferent disturbances of the accommodation reflex.

Accommodation, Ocular↗
PubMed1975

[Objective determination of accommodation in eyes with permanent central scotoma due to amblyopia (author's transl)].

Objective determination of accommodation in 38 children with permanent central scotoma due to amblyopia on one side (with central and eccentric fixation) revealed: 1. The physiological adaptation of refraction for far and near distances did not serve its purpose. 2. There was either no or an irregular response on hyperopia, which was produced by placing concave lenses in front of the eye while fixing a far object, or on myopia produced by placing convex lenses in front of the eye while fixing a near object. 3. On hindering clear vision which could not be compensated by accommodation there was contrary to normal eyes no reactive change of refraction at all or only a poor one. The accommodation behavior in eyes with permanent central scotoma due to amblyopia does not differ from that in eyes with permanent central scotoma due to organic lesions when using the same test methods.

Accommodation, Ocular↗
PubMed1975

Isolation and characterization of a mitochondrially synthesized polypeptide from Neurospora crassa cni-1 mutant.

A polypeptide with a molecular weight of 8 500 (HP 8 500) was isolated from the mitochondrial membrane of the nuclear mutant cni-1 of Neurospora crassa. This mutant is characterized by a cyanide-insensitive respiration and by a deficiency in the cytochromes aa3 and b. The polypeptide is synthesized on mitochondrial ribosomes. It has an extremely hydrophobic character; it is insoluble in aqueous media in the absence of sodium dodecylsulfate and is soluble in acid chloroform/methanol. It lacks histidine. The polar amino acids lysine, arginine, aspartic acid, glutamic acid, serine and threonine make up only 25% of the total amino acids on a mole-percent basis. The N-terminal amino acid is tyrosine. The possible function of this polypeptide in the mitochondrial membrane is discussed.

Cell Nucleus↗
PubMed1975

Electrostimulation in the management of chronic pain.

A new form of electrostimulation was investigated in a series of 768 patients with chronic pain. The method is based on the insertion of needle-electrodes in symmetrically selected points of the body and the passage of an electrical current of specified parameters. Treatment sessions last about 15-20 min and are repeated at intervals of 1 to 7 days. The procedure is simple and free from undesirable side effects. The investigation was based on 12000 sessions. The results of the treatment are discussed. No hypothesis of the mechanism of the beneficial effects obtained by electrostimulation is given, though the gate control theory of pain is cited.

Chronic Disease↗
PubMed1975

[Visual training of partial blinds due to organic lesions (author's transl)].

The immanent sense of optic orientation in space is related to the unchangeable line of principal visual direction and its collaterals. Therefore in patients with loss of central vision due to organic lesion the orientation in space is impaired as well. as a result of a vicious circle of indistinct vision, eccentric fixation and suppresion of foveal perception. By a systematic training the normal sense of direction may be restored and thereby relatively good orientation and by reactivation of the suppressed macular perceptions some reading ability may be regained. Based on experience during 15 years the special diagnostic, the training course and the results of the method are reported and the possibility of rehabilitation of patients with to a high degree impaired central vision due to organic lesions is shown.

Adolescent↗