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J Osborn

Publications and source records attributed to J Osborn.

59 records · Page 4Linked to original sources
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Effect of regional heating of upper body on the liver blood flow in rats.

The changes in rat liver blood flow, caused by hyperthermia, were studied. The liver region of rats was heated with Thermotron IV, an experimental capacitive heating device utilizing 8 MHz RF, and the liver blood flow was measured with radioactive microspheres. Portal venous blood flow slightly decreased during 30 min heating of the liver at 41 degrees C and returned to control level after the heating. When the liver was heated at 43 degrees C, portal venous blood flow decreased initially by about 20%, but gradually returned to control level during the 30 min heating. Hepatic arterial blood flow increased slightly during 30 min heating at 41 degrees C and 43 degrees C. Because almost 85% of the liver blood flow is portal venous blood flow, the change in total liver blood flow paralleled the change in portal venous blood flow. During regional heating of the liver the cardiac output declined significantly, which may account in part for the decrease in splanchnic blood flow, and thus portal venous blood flow. Changes in vascular resistance in the viscera may be another reason for the decrease in portal venous blood flow during heating of the liver region.

Animals↗
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Is aging a real risk factor for urological pathologies in men and women?

OBJECTIVE: With the progressive aging of the population in industrialized countries, urological pathologies are also increasing and creating a socio-sanitary problem for the community. To investigate this problem we retrospectively analyzed a heterogeneous sample of 283 patients, 134 males and 149 females who attended our urodynamics laboratory. METHODS: The female patients were subdivided into 6 categories and the male patients into 7 categories according to their urodynamic diagnoses. Their age distributions were compared with those of the population of the region of Lazio in Italy in order to calculate the "risk tendency". RESULTS AND CONCLUSIONS: The most frequent pathologies in males were bladder outlet obstruction (BOO) associated or not with detrusor overactivity (DO), and in females it was cystocele associated or not with DO or obstruction. There is a significant increase in these urological pathologies in older people. The relative risks for the females increase from age 20-29, stabilize at around 50 to 69 years and decline thereafter. The risk approximately doubles every ten years of age from 20 to 50. At ages 50-69 the risk is about 8 or 9 times higher than the risk at age 20-29 and double that of women aged over 70 years. The risk for the males also approximately double for every ten years of age. Men aged 60-69 have about 25 times the risk of these pathologies than men aged 20-29, and in the oldest men, those over 70 years, the risk is almost 40 times as high.

Adult↗