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J Orson

Publications and source records attributed to J Orson.

6 recordsLinked to original sources
PubMed2000

Using the Internet to enhance evidence-based practice.

Evidence-based healthcare requires reliable and validated research findings to aid improved clinical practice. The Internet, with its growing medical resources, is an invaluable tool for busy healthcare workers. However, as more material becomes available on the web, the quality and reliability of various information sites is a worry for many practitioners. The ability to evaluate web sites is becoming increasingly important and as a novice user, I was interested to discover the extent to which the Internet could assist me researching a specific topic. This article describes the process of conducting an Internet search, on a topic relevant to theatre nursing, and considers how the resources might best be evaluated.

Attitude of Health Personnel↗
PubMed1985

The effect of phenytoin on testosterone metabolism in vitro.

We recently encountered a male newborn with ambiguous genitalia who had been exposed to the anticonvulsant phenytoin in utero. In an attempt to investigate a possible teratogenic connection between phenytoin exposure and genital anomalies, the effect of phenytoin on the conversion of testosterone to dihydrotestosterone by human skin slices was studied. Neonatal foreskins obtained at circumcision were incubated for two hours with testosterone-4-14C and various concentrations of phenytoin. The incubation mixture was then assayed for testosterone, dihydrotestosterone, androstanedione, androstenedione, androstanediol, and androsterone using thin-layer chromatography and liquid scintillation spectrometry. The amounts of testosterone metabolites formed with phenytoin added were compared to values obtained under control conditions without phenytoin. There was a significant decrease in the amounts of 5 alpha reduced metabolites formed with increasing amounts of phenytoin added. Implications for male phenotypic sexual differentiation of the fetus exposed to phenytoin in utero are discussed.

Adult↗