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Biomedical subjects

J Orford

Publications and source records attributed to J Orford.

At least 19 recordsLinked to original sources
PubMed1995

Bleomycin therapy for cystic hygroma.

Intralesional bleomycin injection was used as sclerosant therapy for sixteen patients with cystic hygroma. An excellent (complete clinical resolution) response was obtained in seven (44%) patients, a good (> 50% response) result in seven (44%), and a poor or no response in two (12%). Minor transient side effects (fever, vomiting, cellulitis, skin discoloration) were seen in six patients, and there were no serious side effects. The results suggest that bleomycin intralesional sclerosant is effective therapy for cystic hygroma, with response rates comparable to those of surgical removal, but with the advantage of avoiding inadvertent nerve damage and scarring.

Bleomycin↗
PubMed1993

The families of problem drug users: a study of 50 close relatives.

The research described in this paper resulted from a collaborative multi-centre study of the relatives of problem drug users involving six practitioners and researchers, in four centres within the south-west of England. The objective of this research was simply to interview 50 close relatives of identified problem drug users, with the identification occurring through clinics and self-help groups. Quantitative and qualitative results show that large numbers of these relatives reported many negative experiences. The partners of illicit drug users reported both more and differently patterned problematic behaviours than those of prescribed tranquillizer users. The partners of illicit users also reported different problems to those of the parents. Relatives reported many negative effects in terms of how they viewed the drug user, and how the experiences had affected their health. They also described various coping mechanisms, and the extent of the support which they had received. The results are discussed in terms of coping, and similarity with research into the families of problem drinkers.

Adaptation, Psychological↗
PubMed1993

Alcohol problems.

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Alcoholism↗
PubMed1993

The adult adjustment of offspring of parents with drinking problems.

One hundred and sixty-four 16-35-year-old offspring of parents with drinking problems, recruited from a variety of clinical and community sources, were compared with 80 respondents of similar ages from similar sources who did not have parents with drinking problems. Each was interviewed using a semistructured interview. Adult adjustment was similar in the two groups, but the offspring of parents with drinking problems did report considerably more disharmony in their families of origin, and many more childhood difficulties. Factor analysis of the adult adjustment data for the samples combined showed four factors which accounted for 41% of the variance; these factors differed little in their effect in the two groups. The groups' reports of the drinking problems of their siblings, however, suggests that this sample might be unrepresentative of the true risk to the children of parents with drinking problems for the development of alcohol-related (although not other) difficulties in adulthood: 16% of this group reported a sibling with a drink problem and a further 9% were unsure, but only one member of the comparison group reported a sibling with a drink problem, and one was unsure. Path analysis showed that both parental problem drinking and family disharmony are related in complex ways to adjustment difficulties in adulthood. 'Demoralisation', the largest of the four factors, was particularly related to disharmony in the family of origin: in the absence of disharmony, offspring versus comparison status was negatively correlated to demoralisation in adulthood, suggesting that having a parent with a drinking problem might sometimes be a strengthening experience.

Adaptation, Psychological↗
PubMed1992

Davidson's dilemma.

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Behavior Therapy↗
PubMed1992

Control, confront or collude: how family and society respond to excessive drinking.

Research on excessive drinking in the family context has revealed the range of ways of coping used by close relatives. Case material from ongoing research in England and Mexico is used to illustrate this point. This research is also revealing the ways in which the family, close and extended, often fail to support the coping actions of close relatives. The analogy is drawn between coping with excessive drinking in the family and coping in the work setting. In the latter context explicit alcohol policies have been developed. These often recommend combining confrontative and supportive coping. It may be difficult for relatives, in the family setting, to adopt such a policy without support. The forms of coping identified in family research and in work policies correspond to basic and universal dimensions of interpersonal behaviour: dominance-submissiveness and friendliness-hostility. These forms of responding to excessive drinking may be identified beyond the microsocial systems of family and workplace. They are evident, also, in the responses of community agents such as police and social workers, and at the level of local and national government.

Adaptation, Psychological↗
PubMed1992

Drinking amongst medical patients: levels of risk and models of change.

Results are reported of a study in which 547 general hospital medical in-patients were screened, using a computer-administered questionnaire, for alcohol consumption, problems and concerns. Of males, 22.5% were classified as 'risk drinkers', of women 6.5%. Rates of risk were particularly high amongst younger male patients. It was concluded that certain screening questionnaire items were more useful than others in the general hospital context, and that standard questionnaires developed for other populations should not automatically be used in general hospitals. Comparisons with items relating to other health behaviours suggested that the medical profession, the general public and the patients themselves might be relatively insensitive to the risks associated with heavy drinking in comparison to those associated with smoking, weight and lack of exercise. Data from initial screening and from 75% of patients who were asked to repeat the questionnaire six months later, were used to test certain assumptions of a model of change based in part upon that of Prochaska & DiClemente (1986). Results suggested that processes of change were more complex than the model supposed.

Adolescent↗
PubMed1991

The environmental intergenerational transmission of alcohol problems: a comparison of two hypotheses.

Two competing hypotheses concerning the mechanism of transmission of excessive substance use from one generation to the next are tested, using data from a study of 16- to 35-year-old offspring of problem-drinking parents. The 'positive influence' hypothesis predicts that the more positive has been the offspring's relationship with the problem-drinking parent during upbringing, the greater the risk of excessive drinking or drug taking in young adulthood. This hypothesis received support only for women with fathers with drinking problems. The 'relationship deficiency' hypothesis predicts that those offspring most at risk are those who have had the more negative relationships with parents. This hypothesis received some support in the case of men with mothers with drinking problems: this subgroup of offspring were more at risk if they reported having had poor relationships with their fathers. It is concluded that the environmental intergenerational transmission of problems of excessive substance use occurs via a variety of mechanisms which are likely to be of differential importance in different subgroups.

Adolescent↗
PubMed1990

Offspring of parents with drinking problems: drinking and drug-taking as young adults.

One hundred and seventy 16 to 35 year-old offspring of parents with drinking problems and 80 comparison young adults were recruited from a variety of clinical and community sources. Each was interviewed at length using a semi-structured interview and 86% were re-interviewed one year later. No between-group differences were found in current quantity of alcohol consumption nor in percentages who had ever used or were currently using illicit or prescribed drugs. However, larger numbers of offspring had commenced alcohol use in their early teens and had used other drugs in their later teens, and more offspring than comparisons were currently using alcohol in a risky way, more were using illicit drugs more than occasionally, and more were heavy smokers. These differences were not great, and gender and source of recruitment (clinical versus community) were equally important predictor variables. Analyses conducted within the offspring group offered no support for hypotheses linking adulthood risk with years of exposure, severity of childhood effects and experiences, maternal as opposed to paternal problems, or problems in the same sex parent. However, some support was found for the importance of having had two parents with drinking problems and having had a drinking parent who often drank at home.

Adolescent↗
PubMed1990

Young adult offspring of parents with drinking problems: recollections of parents' drinking and its immediate effects.

One hundred and seventy 16- to 35-year-old offspring of parents with drinking problems were recruited from a variety of clinical and community sources and each was interviewed at length using a semi-structured interview. The present paper focuses upon carefully reconstructed recollections of childhood, and presents quantitative information from the whole sample and three briefly described individual examples. Large variances on quantitative measures and very varied qualitative accounts of childhood were evident. The large majority described parental drinking problems which spanned their childhood and adolescent years without interruption and without treatment. Amongst the most frequently recalled effects on life at home were parental moodiness, unreliability, and a tendency to upset or fail to join in with family activities. Amongst negative childhood experiences recalled most frequently were worry and uncertainty, a feeling of family instability, the experience of being caught between the interests of two parents, and the adoption of certain adult roles. Those with mothers with drinking problems scored significantly higher on a scale of negative childhood experiences and mothers with drinking problems were more likely to have drunk regularly at home. Those offspring from families of higher social status estimated their parental problems to have started slightly later in childhood. Qualitative analysis suggested that whether excessive parental drinking is perceived as alien to or integral with family life may have been a neglected variable.

Adaptation, Psychological↗
PubMed1987

Expressed emotion and perceived family interaction in the key relatives of elderly patients with dementia.

Four groups of families were investigated using an interview designed to assess expressed emotion (EE) in relatives of psychiatric patients and a family interaction questionnaire (FIQ) based upon the Leary and Benjamin schemes for coding interpersonal behaviour. The families included 25 containing a psychiatric patient aged between 18 and 46, and three groups of 12 families each, all containing a patient over 60 (patients with dementia, a functional psychiatric disorder, or a chronic physical disorder respectively). In all cases data were obtained from key relatives. The FIQ clearly separated out the group of dementia relatives who reported the most dominant and protective behaviours and the highest levels of hostile-dominance and the lowest levels of affection. EE was not found to be so sensitive to interactions occurring in families with a member with dementia, and the possible reasons for this are discussed.

Adaptation, Psychological↗
PubMed1986

Abstinence or controlled drinking in clinical practice: indications at initial assessment.

Previous research has suggested two leading hypotheses concerning which excessive drinkers can re-establish control: one based upon level of dependence, the other upon the client's personal persuasion. Using initial assessment data from 46 clients of a clinical psychology alcohol problems service (30 men, 16 women), an attempt was made to operationalize the concepts of dependence and personal persuasion using a variety of indicators of each. Although SADQ scores and Rand definite alcoholism were in general agreement, there were a number of borderline instances and cases of disagreement, and neither was in good agreement with estimates of problem duration, nor with reports of recent or earlier attainment of abstinence or control. Indicators of personal persuasion were more consistent. Those with dependence indicators for abstinence tended to prefer abstinence as a goal, but there were many departures from this pattern particularly for women. It is concluded that in clinical practice it will be very difficult to make a clear cut recommendation about treatment goal at initial assessment except in a few cases.

Adult↗
PubMed1985

Gender differences in the functions and effects of moderate and excessive drinking.

In a study comparing abstinence and controlled drinking treatments, differences were found between men (n = 30) and women (n = 16) which confirmed some previous views on sex differences and problem drinking, and which have implications for choice of drinking treatment goal. On average women had problems of shorter duration, were less likely to have previously received out-patient specialist treatment only, reported consuming smaller quantities of alcohol, and reported a more regular recent pattern of consumption. Mean SADQ scores, and numbers 'definitely alcoholic' by Rand criteria, were similar, as were the numbers reporting a positive family history of drinking problems. Contrary to expectations, women were no more likely than men to report interpersonal functions and effects of drinking. Men were more likely than women to report drinking for positive emotional or social reasons or because of social pressure, were more likely to report positive effects of drinking, and among negative effects were more likely than women to report effects on work, finances, leisure, and fitness. Levels of self-esteem were very similar, but men described more positive effects of moderate drinking upon self-esteem than women.

Adult↗
PubMed1984

The prevention and management of alcohol problems in the family setting: a review of work carried out in English-speaking countries.

There are at least six theoretical perspectives that underlie studies of alcohol misuse and the family. Adherence to one or to a limited range of viewpoints constricts the outlook of professional workers. The prevention and treatment of alcohol problems in the family setting is a neglected field, yet it offers scope for intervention with high risk groups, and at an incipient stage of alcohol misuse before help is normally sought. Despite the growing use of marital and family therapy for couples and families containing a problem drinking member, evaluative studies of such therapies generally lack methodological rigour and leave important issues unresolved. Nonspecialist professional agencies who encounter family problems often fail to identify or deal with alcohol misuse when it is present. Trained voluntary workers may be effective in the treatment of alcohol problems within the family context. There are disadvantages from viewing alcohol misuse within the family as a topic separate from other health and social problems. Finally, the issues that are reviewed have relevance for non-English speaking countries.

Adult↗