The serovar distribution of 53 Chlamydia trachomatis strains obtained from 53 clinical isolates in Amiens (France) was studied by a micro-immunofluorescence test with a panel of 15 monoclonal antibodies. The isolates were of ocular (babies) or urogenital origin (adults). This typing showed that E was the most common serovar (62.3%) followed by F (9.4%), Ba, D, J (5.6%), H (3.8%) and G, K (1.9%). Two mixed infections were detected (one EG and one FG). Consequently, the serovar distribution of C. trachomatis in Amiens (France), was characterized by a predominance of serovar E higher than in other European countries.

Adult↗

PubMedDate not supplied

Screening for Chlamydia trachomatis infection in pregnant women in Martinique.

GOAL OF THIS STUDY: To determine the prevalence of Chlamydia trachomatis urogenital infection and to identify behavioral, demographic, and clinical factors associated with the infection in pregnant women in Martinique. STUDY DESIGN: One-thousand-four-hundred-eleven patients 15-39 years old, at 10-16 weeks of gestation and attending the prenatal clinic at Lamentin Hospital, were tested for Chlamydia trachomatis infection of the cervix and urethra using tissue culture. RESULTS: Chlamydia trachomatis was isolated from 375 (26.7%) women; 34% of them were positive in the cervix and urethra, 58% in the cervix only, and 8% in the urethra only. Factors found by multivariate analysis to be significantly associated with chlamydial infection were age less than 25 years, first intercourse at less than 18 years old, previous induced abortions, mucopurulent cervicitis, and repeated candidiasis. CONCLUSIONS: None of the factors associated with chlamydial infection was sensitive enough to permit efficient selective screening. It is cost effective to recommend a routine screening for chlamydial infection together with an educational program.

Abortion, Induced↗

PubMedDate not supplied

Ankylosing spondylitis and chlamydial infection in apparently healthy HLA B27 blood donors.

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Adult↗

PubMedDate not supplied

[Kinetic study, in the mouse, of anti-chlamydia antibody formation: demonstration of target antigenic molecules].

A kinetic study of chlamydia antibody was performed in the C57BL/6 mouse to demonstrate whether some cell wall polypeptides could be useful in the detection of early infection. Polyacrylamide gel electrophoresis was employed, followed by electrophoretic transfer to nitrocellulose sheets of the polypeptides, separated according to their molecular weights. One polypeptide triplet appeared to be very interesting, that of 66, 65 and 64 Kd. The first two, and particularly the 65-Kd polypeptide, were determinant carriers which provoked an antibody response in the C57BL/6 mouse during an early phase of infection by the two species of chlamydia; the 65-Kd polypeptide reacted only with C. psittaci. The extension of this study to human disease was undertaken and preliminary results are encouraging; polypeptide markers of early infection in the C57BL/6 mouse, and especially that of 65 Kd, were revealed by the tested human sera and provoked the same type of response. A more extensive study in human species, in correlation with clinical observations, is currently being undertaken in our laboratory.

Animals↗