Search PubMed⌕ Search

Biomedical subjects

J Olsen

Publications and source records attributed to J Olsen.

At least 127 records · Page 7Linked to original sources
PubMed2000

Birth outcomes of women with ulcerative colitis: a nationwide Danish cohort study.

OBJECTIVE: Our study aimed to compare the birth outcomes in offspring of women with ulcerative colitis with controls without the disease. METHODS: A cohort study of 1531 newborns to mothers with ulcerative colitis, and 9092 controls, based on linkage between the Danish National Registry of Patients and the Danish Birth Registry from 1982 to 1992. RESULTS: Among the births to women with ulcerative colitis, 569 took place before and 962 after the first hospitalization for ulcerative colitis. We found no increased risk of either low birth weight or intrauterine growth retardation for newborns born before or after the mothers' first hospitalization. The risk of preterm birth was increased when birth occurred after the mothers' first hospitalization (odds ratio = 1.4, 95% confidence interval = 1.1-1.9), and particularly when the first hospitalization for ulcerative colitis took place during pregnancy (odds ratio = 3.4, 95% confidence interval = 1.8-6.4). CONCLUSIONS: In the offspring of women with ulcerative colitis, we found no increased risk of low birth weight or signs of intrauterine growth retardation. The risk of preterm birth was increased in the offspring of women with ulcerative colitis, particularly when the first hospitalization for ulcerative colitis occurred during pregnancy.

Adult↗
PubMed2000

Attraction of adult Rhagoletis indifferens (Diptera: Tephritidae) to unbaited and odor-baited red spheres and yellow rectangles.

Five sizes of red spheres (4, 6, 8, 10, and 12 cm diameter) and 2 orientations of yellow rectangles (vertical and V) were evaluated as unbaited sticky-coated traps for western cherry fruit flies, Rhagoletis indifferens Curran, in unmanaged cherry trees in Washington and Oregon. Red spheres that were 10 cm in diameter attracted more flies than red spheres that were 8 or 12 cm in diameter and significantly more flies than 4- or 6-cm spheres and yellow rectangles of either orientation. In a 2nd test, red spheres (10 cm diameter) baited with ammonium carbonate alone or ammonium carbonate plus putrescine attracted significantly more R. indifferens than similar spheres baited with ammonium acetate alone, putrescine alone, 3-methyl-1-butanol alone, or combinations of these substances. In a 3rd test, vertical yellow rectangles baited with ammonium carbonate alone attracted numerically more R. indifferens than any of the aforementioned substances alone or in combination. We discuss the potential value of 10-cm red spheres baited with ammonium carbonate for monitoring and direct control of R. indifferens.

Animals↗
PubMed2000

Male-mediated spontaneous abortion among spouses of stainless steel welders.

OBJECTIVES: Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents. Clinical and early subclinical spontaneous abortions were examined among spouses of stainless-steel welders. METHODS: A cohort of first-pregnancy planners was recruited from members of the union of metal workers and 3 other trade unions. The cohort was followed for 6 menstrual cycles from the cessation of contraceptive use. Altogether, 280 pregnancies were conceived, of which 35 were detected by human chorionic gonadotrophic hormone analysis and did not survive to a clinically recognized pregnancy. Information on exposure was collected prospectively in relation to the outcome and was available for all cycles resulting in a pregnancy. Information on pregnancy outcome was collected for all 245 clinically recognized pregnancies. RESULTS: Increased risk of spontaneous abortion was found for pregnancies with exposure to paternal stainless-steel welding (adjusted relative risk 3.5, 95% confidence interval 1.3-9.1). The results were consistent in analyses of both biochemically and clinically recognized abortions. There was no increased risk for spontaneous abortion in pregnancies with paternal exposure to the welding of metals other than stainless steel. CONCLUSIONS: Male welding of stainless steel was associated with an increased risk of spontaneous abortion in spouses. A mutagenic effect of hexavalent chromium has been found previously in both somatic and germ cells, and the findings could be due to mutations in the male genome.

Abortion, Spontaneous↗
PubMed2000

A population-based case-control teratologic study of furazidine, a nitrofuran-derivative treatment during pregnancy.

OBJECTIVE: To study human teratogenic potential of furazidine treatment during pregnancy. DESIGN: Pair analysis of cases with congenital abnormalities and matched population controls. SETTING: The Hungarian Case-Control Surveillance of Congenital Abnormalities. PARTICIPANTS: 38,151 pregnant women who had newborn infants without any defects (population control group) and 22,865 pregnant women who had newborns or fetuses with congenital abnormalities between 1980 and 1996. RESULTS: In the case group, 157 (0.7%) and in the control group, 254 (0.7%) pregnant women were treated with furazidine. The case-control pair analysis did not indicate a teratogenic potential of furazidine use during the second to third months of gestation, i.e. in the critical period for major congenital abnormalities. CONCLUSION: Treatment with furazidine during pregnancy did not show teratogenic risk to the fetus.

Abnormalities, Drug-Induced↗
PubMed2000

A follow-up study of birth outcome in users of pivampicillin during pregnancy.

BACKGROUND: Pivampicillin is a prodrug which is widely used in Scandinavian countries for oral antibiotic therapy. The pivaloyl moiety has a carnitine depleting effect, which has caused doubts about the safety of administering pivampicillin during pregnancy. The aim of the study was to evaluate the risk of congenital malformations in general, preterm delivery and low birth weight in users of pivampicillin. METHODS: Seven hundred and ninety-one women who had redeemed a prescription of pivampicillin during their first pregnancy from 1 January 1991 to 31 December 1996 were identified in the North Jutland Pharmaco-Epidemiological Prescription Database. By linkage to the Danish Medical Birth Registry and Regional Hospital Discharge Registry we compared their birth outcomes (malformations, preterm delivery and low birth weight) with the outcomes in 7472 reference pregnancies on which the mother had not redeemed any prescription at all during pregnancy. RESULTS: The prevalence of malformations was 5.5% (11 cases) in offspring of 199 women who had used pivampicillin during the first trimester, and 5.6% (420 cases) in offspring of controls (OR: 0.95, 95% CI: 0.51-1.76). Furthermore, we did not find any significant risk of preterm delivery (OR: 0.75, 95% CI: 0.54-1.05) or low birth weight (OR: 0.93, 95% CI: 0.55-1.57). CONCLUSION: This study showed no increased risk of congenital malformations, preterm delivery or low birth weight in offspring of women who had redeemed a prescription for pivampicillin during pregnancy.

Abnormalities, Drug-Induced↗
PubMed1999

[Semen quality and fertility in a population-based follow-up study].

Little is known about the importance of semen quality in male infertility. We followed 430 first pregnancy planners with no previous reproductive experience recruited among more than 50,000 cohabiting trade-union members. The couples were consecutively enrolled into the study as they discontinued contraception and were followed up for six month menstrual cycles or until a pregnancy was verified. Each man provided a semen sample at enrollment. Women kept daily record of vaginal bleeding and sexual activity. The probability of conception increased with increasing sperm concentration up to 40 x 10(6)/ml, but any higher sperm density was not associated with additional likelihood of pregnancy. The proportion of sperm with normal morphology was strongly related to likelihood of pregnancy, independently of sperm concentration. In conclusion, sperm concentration and morphology are valuable biological markers of male fecundity. Reference values for semen quality based on biological knowledge can be established.

Biomarkers↗
PubMed1999

Recurrence risk of congenital anomalies--the impact of paternal, social, and environmental factors: a population-based study in Denmark.

The authors investigated the recurrence risk of congenital anomalies as a function of changes in genetic and environmental factors in single births following the birth of a child with an anomaly. The study is a population-based historical follow-up using the Danish Medical Birth registry, hospital discharge diagnoses, and Statistic Denmark's Fertility Database. The investigators identified 8,671 women who gave birth to a child with a diagnosed malformation between 1980 and 1992 and had a subsequent birth. Following the birth of an affected infant, 474 (5.5%) women gave birth to another child with a malformation, 155 of which (1.8%) were similar to the malformation of the older sib or half sib. When the father changed between the two births, the risk of a similar anomaly was significantly reduced (odds ratio (OR) = 0.26, 95% confidence interval (CI) 0.11, 0.65). Higher social status at enrollment was associated with a lower recurrence risk (OR = 0.67, 95% CI 0.45, 0.99, for the middle status group and OR = 0.49, 95% CI 0.30, 0.81, for the highest status group), independently of partner change. A rise in social status between the two births was marginally associated with a decline in the recurrence risk. No variation in the recurrence risk associated with change of municipality or occupation was seen.

Cohort Studies↗
PubMed1999

Predicting quality of life from symptomatology in schizophrenia at exacerbation and stabilization.

There has been little research investigating how symptoms of schizophrenia and changes in symptomatology across the course of the illness relate to measures of quality of life in patients. We examined this issue in 45 patients assessed at hospital admission for illness exacerbation, at stabilization (prior to discharge) and at follow-up (5-9 months post-discharge). Symptom ratings at each time period consisted of the Brief Psychiatric Rating Scale (BPRS) and the Negative Symptom Assessment (NSA). The Heinrichs-Carpenter Quality of Life Scale (QLS) was administered upon admission to the hospital (assessing the 3 months prior to admission) and again at follow-up. Correlational analyses revealed relationships of both positive and negative symptoms with quality of life. These relationships are particularly strong at stabilization. Stepwise regression analyses revealed changes in the NSA motivation component to be most important in predicting quality of life for the patients at follow-up. BPRS psychosis and paranoia components are important predictors of quality of life at stabilization (but not during acute exacerbation). These results are important in terms of understanding the impact of changes in symptomatology on the quality of life for patients with schizophrenia as well as in targeting specific symptom clusters for treatment to maximize quality of life post-hospitalization.

Acute Disease↗