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Biomedical subjects

J Olsen

Publications and source records attributed to J Olsen.

At least 541 records · Page 30Linked to original sources
PubMed1976

The oxidation of dithiothreitol by peroxidases and oxygen.

Horseradish peroxidase (1.11.1.7), lactoperoxidase (1.11.1.7), and the fragment of cytochrome c known as microperoxidase have been shown to catalyze the oxidation of reduced dithiothreitol in an oxygen-consuming reaction. Evidence for horseradish peroxidase intermediates compound III and compound II has been observed, although ferroperoxidase was not identified during the course of the reaction. The stoichiometry has been extablished as 1 : 1 for oxygen consumed to dithiothreitol oxidized. Cysteine and glutathione have also been shown to be substrates for horseradish peroxidase oxidase reaction.

Catalase↗
PubMed1976

Gatric carcinoma. A prospective study of tumour differentiation correlated to surgical procedures and survival rate.

A prospective study of 100 consecutive patients operated for gastric carcinoma is presented. The resectability was 43 per cent. Primary mortality for palliaktive resections including total gastrectomy was 3.8 per cent with a 2-year survival rate of 20 per cent. The primary mortality and the 2-year survival after palliative surgical procedures including total gastrectomy justify these procedures. Based on histological qualities of the tumourcells a Differentiation Coefficient is defined. In these patients the coefficient could not be compared to the survival rate.

Adult↗
PubMed1976

Replica cytology in cancer of the larynx: an evaluation of a replica method in the diagnosis of laryngeal malignancy.

A series of 38 cytological samples from the larynx, obtained with a replica method, is presented. The method is described in detail. Conclusive material was obtained in 34 cases. Fourteen per cent false negative evaluations were found. However, when more strict criteria were used for accepting the cytological specimen as suitable for evaluation, no false negative was encountered. It is therefore concluded that this replica method for obtaining cytological samples from the larynx could become a valuable tool as a screening method during indirect laryngoscopy in search of laryngeal malignancy provided very strict criteria are used for accepting the cytological specimen as suitable for evaluation.

Carcinoma, Squamous Cell↗
PubMed1975

Exfoliative cytology in the diagnosis of laryngeal malignancy.

In searching for a screening procedure in the diagnosis of laryngeal malignancy the authors have evaluated a cytological examination, adapted for indirect laryngoscopy, and present the results of 149 consecutive smears from the larynx. Forty-four per cent of the smears were false negative, and it is concluded that exfoliative cytology with this method has no place as a screening procedure in the diagnosis of laryngeal malignancy. The method is inferior to the evaluation of the clinical picture in indirect laryngoscopy, and the selection for direct laryngoscopy and biopsy for histological evaluation should be based upon the clinical evaluation.

Biopsy↗
PubMed1975

Assessment of verapamil in the treatment of angina pectoris.

A brief review is given of the pharmacological data of verapamil, which chemically shows a certain similarity to papaverine. The effect of the drug (80 mg) 3 times daily, on angina pectoris, as compared with placebo, was evaluated in a double-blind cross-over therapeutic trial with 4-wk periods in 47 patients. The incidence of attacks and the nitroglycerine consumption decreased in the second fortnight of the verapamil period by approximately 25% compared with the placebo period. An ergometer test showed a prolongation of the exerice time of 20%. The mean blood pressure and the heart rate fell under verapamil treatment if the patients had values which were relatively high in the placebo period. The increase in heart rate during exercise from two different resting levels showed a tendency to become more pronounced under treatment with verapamil than under placebo. The length of the P-Q intervals were not affected by verapamil. The mechanism of action in angina pectoris is discussed, but it is concluded that it is still not possible to explain it. Twelve Danish medical departments took part in the trial.

Aged↗