Discordance in sperm morphology determination by strict criteria (SC) and WHO criteria, pointing out the necessity of sperm morphology determination by SC.
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Humans↗
Biomedical subjects
J Olmedo
Publications and source records attributed to J Olmedo.
A new case of polyarthritis as a presenting sign of non-Hodgkin's lymphoma.
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Aged↗
Induced acrosome reactions as fertility predictor.
PURPOSE: This study was conducted to determine the fertility predictive value of acrosome reaction rates and indices (induced minus control) of human spermatozoa. By comparison these outcomes with in vitro fertilization success. The effect of oocyte-cumulus complex exposure on the induction of the acrosome reaction was also analyzed. Patients attending our assisted reproduction unit for infertility treatment were included in the study. Acrosome reactions were determined on ethanol-permeabilized smears using FITC-conjugated Pisum sativum agglutinin. The acrosome reaction inducing agent used was calcium ionophore A23187 (10 microM/ml). RESULTS: Poor correlations were found between all the acrosome reaction rates and indices and in vitro fertilization. The presence of oocyte-cumulus complexes had no effect on the spontaneous acrosome reactions, but had a significant effect on the inducibility of the acrosome reaction. Exposure to oocyte-cumulus complexes resulted in the mean percentage sperm induced to be 7.8% (SE = 3.1%) higher compared to the control samples. CONCLUSIONS: Acrosome reaction rates and indices were therefore found to have no significant value in the prediction of male fertility and/or in vitro fertilization success. This study did, however, show that exposure to oocyte-cumulus complexes significantly increases the inducible sperm population.
Acrosome↗
Nodular regenerative hyperplasia of the liver. Report of two cases associated with autoimmune disease.
Nodular regenerative hyperplasia of the liver (N.R.H.) is an uncommon clinicopathological entity characterized by diffuse regenerative hepatocytic nodules without fibrosis. Grossly the lesion is often mistaken for cirrhosis. The etiology and pathogenesis are unknown. We report two new cases of N.R.H. diagnosed by liver biopsy. Peritoneoscopically the liver showed a nodular surface resembling micronodular cirrhosis. Both patients showed some clinical and immunological features of autoimmune disease, and in both cases N.R.H. was associated with chronic active hepatitis. We discuss the pathological differential diagnosis of N.R.H., its relation to other associated diseases and review the hypotheses for the pathogenesis of this condition.
Aged↗
Prognostic value of the strict criteria: an Argentinian experience.
The prognostic value of normal sperm morphology, evaluated according to the strict criteria, was prospectively assessed. The study included 112 IVF cycles. The percentage normal sperm morphology of the semen samples used in each cycle was determined and assigned to one of three prognostic groups; P-pattern (< 4% normal forms), G-pattern (5-8% normal forms), and N-pattern (> 8% normal forms). The fertilization, grade 4 embryo attainment, and pregnancy rates were compared between the three groups. The fertilization rate of the N-pattern group (83.7%) was significantly higher than that of the G-pattern (59.65%) and the P-pattern (22.58%) groups. The grade 4 embryo attainment rate was only significantly different between the N-pattern (23.38%) and the P-pattern (4.76%) groups. No pregnancy was obtained in the P-pattern group compared to a pregnancy rate per transfer of 23.08% in the N-pattern group. This study reaffirms the interlaboratory reproducibility and the prognostic value of normal sperm morphology.
Argentina↗