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Biomedical subjects

J Okubo

Publications and source records attributed to J Okubo.

At least 37 records · Page 2Linked to original sources
PubMed1985

Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats.

The effects of the convulsants strychnine, bicuculline, picrotoxin and L-allylglycine on the transsynaptic destruction of medullary dorsal horn neurons were examined following transection of the inferior alveolar nerve in adult rats. Strychnine and L-allylglycine enhanced the transsynaptic effect of nerve transection and caused degeneration of many dorsal horn neurons, while bicuculline and picrotoxin did not. The removal of glycinergic and GABAergic postsynaptic inhibition appears to enhance the transsynaptic destructive activity which follows the peripheral nerve transection.

Allylglycine↗
PubMed1984

Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection.

The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.

Animals↗
PubMed1979

Epidemiological survey of definite cases of Meniere's disease collected by the seventeen members of the Meniere's Disease Research Committee of Japan in 1975--1976.

Between Aril 1975 and December 1976, the second nationwide survey of Meniere's disease in Japan was made by the 17 members of the Meniere's Disease Research Committee of Japan. The epidemiological data from 520 patients with definite Meniere's disease were analyzed in comparison with those from the 126 patients in the non-Meniere vertiginous group (Control A) and the 228 patients in the rhinolaryngological group (Control B). The male:female ratio of definite cases of Meniere's disease was almost the same, and the age distribution peaked at the age group of 40--49 years for males, while the peak for females was at the age group of 30--39 years. 5.8% of the 520 patients had a close relative who also suffered from Meniere's disease. From the epidemiological features, it may appear that the occurrence of vertiginous attacks in Meniere's disease is influenced much more by individual than by environmental factors. However, this feature can be considered as another evidence of the psychosomatic disorders involved in Meniere's disease.

Age Factors↗