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Biomedical subjects

J Ohkawa

Publications and source records attributed to J Ohkawa.

43 records · Page 3Linked to original sources
PubMed1988

A familial study of C5+cholinesterase and its frequency in the normal population.

A case of familial hypercholinesterasemia was presented. A cholinesterase isoenzyme study revealed the extra C5 band nearer to the cathode than C4 on the gradient polyacrylamide gel electrophoresis in 6 out of 8 subjects in the family. No significant difference in the effect of inhibitors and activator was found when compared with the normal control. We investigated the frequency of variant with C5+cholinesterase in normal healthy subjects. The frequency of the extra C5 band found in the normal healthy population in Japan was 1.2%. It was considered to be clinically useful for differential diagnosis of patients with elevated serum cholinesterase to find subjects with familial hypercholinesterasemia.

Cholinesterases↗
PubMed1984

Clinicopathological study on the relationship between serum-CEA and tissue-CEA of resected lung cancer cases.

The clinicopathological correlation between serum-CEA (s-CEA) and immunohistological tissue-CEA (t-CEA) was studies on 63 cases of operated lung cancers. T-CEA was examined by peroxidase anti-peroxidase (PAP) method. T-CEAs were detected in 36/39 cases (92.3%) of adenocarcinoma, 16/16 cases (100%) of epidermoid carcinoma, 2/5 cases (40%) of large cell carcinoma, and 1/3 case (33.3%) of small cell carcinoma. T-CEAs in adenocarcinoma and large cell carcinoma with mucin exhibited moderate to strong reactivity with diffuse distribution, and also s-CEA of these cases indicated high levels. On the contrary, in epidermoid carcinoma t-CEAs showed a weak reactivity with focal distribution, and s-CEAs also demonstrated low levels. In adenocarcinoma it was suggested that the more cancers were differentiated, the more t-CEA and s-CEA were increased, and about two third of cases showed a balance between t-CEA and mucin content in cancer tissue. S-CEAs were not correlated with the size of the primary lesion or the extent of lymph node metastasis, but with the histological types, i.e. high levels of s-CEA in adenocarcinoma and large cell carcinoma with mucin.

Adenocarcinoma↗
PubMed1984

Application of a Phaseolus vulgaris erythroagglutinating lectin agarose column for the specific detection of human hepatoma gamma-glutamyl transpeptidase in serum.

By making use of the structural change of the sugar chains of liver gamma-glutamyl transpeptidase associated with malignant transformation, a new method has been developed to distinguish human serum gamma-glutamyl transpeptidase associated with primary hepatoma from that of non-hepatoma patients. In principle, the method consists of affinity chromatography of the desialylated serum enzyme on a Phaseolus vulgaris erythroagglutinating lectin agarose column.

Carcinoma, Hepatocellular↗