Biomedical subjects
Publications and source records attributed to J O King.
A case of symptomatic raised intracranial pressure following staged bilateral radical neck dissection is reported. Cerebral computerized tomography was normal. It was considered that the raised intracranial pressure was the result of inadequate collateral venous drainage from the brain.
Two cases of rhinocerebral mucormycosis are reported to draw attention to this fulminating fungal disease. Both patients had diabetes, and presented with a rapidly progressive orbital apex syndrome.
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In 3 experiments growing rabbits were divided into 2 groups. In each case half received a basal ration while the other half was given this ration supplemented with a ground fibrous material: 20% hay, 10% straw or 10% paper. All the diets were fed in pelleted form. In all the experiments the rabbits fed on the diets containing the added fibrous materials gained in weight slightly more rapidly and had slightly higher food conversion ratios than did those on the control diet, but the differences in the means were not significant. A study of the small intestine and caecum weights expressed as percentages of body weight and as the weights of 1-cm lengths showed that the added fibrous materials increased these weights except in 1 instance where the results were the same. Significant changes were recorded in the case of hay in both the percentage weight and the weight of 1-cm lengths of caecum and in the straw experiment in the weight of 1-cm lengths of small intestine. There were no significant changes in the results from the paper-fed rabbits.
Ninety-six cows (48 Ayrshires and 48 Friesians) were weighed at seven day intervals. Forty-six cows gained weight and showed significant average increases in milk yield and solids-not-fat (SNF) percentage and non-significant rises in protein percentage and freezing point. The fat percentage was significantly lowered. The other 50 cows lost weight and a significant drop in SNF percentage was recorded. The other parameters showed non-significant falls.
Observations were made on 249 first or second calf heifers in which mastitis had been diagnosed in a mammary quarter which was opposite a normal quarter. Cell counts were made on the milk from each quarter and the cows were divided into three groups with the infected quarters classed according to the cell count. The infected quarters gave lower yields of milk with lower fat, solids-not-fat (SNF) and protein percentages than the opposite normal quarters in all three groups, but the differences between the means were only significant in yield and fat and SNF contents in the two groups with cell counts of over 500,000 per ml. In 175 animals the numbers and diameters of the fat globules were measured. The only significant reduction was in the globule numbers in the cows with from 1 to 2 million globules per ml of milk.
Observations were made at the evening milkings on the day before and immediately after 131 cows housed and milked in cowsheds had been disturbed by parties of visitors. The cows were divided into three groups according to the extent of the reduction in milk yield following the visits. In the two groups showing the greatest differences the disturbances significantly reduced the fat and solids-not-fat (SNF) percentages and raised the milk cell counts.
The rectal temperatures, pulse rates and milk yields of 44 Ayrshire and 38 Friesian cows were recorded during oestrus and compared with values obtained after oestrus had ceased. The fat, solids-non-fat (SNF) and protein percentages and the cell counts of milk samples were also compared. Forty of the cows were housed in cubicles and 42 were kept loose in yards. During oestrus rectal temperatures and pulse rates were significantly raised and milk yields were lowered. Milk had, on average, significantly higher fat contents and cell counts and lower SNF and protein contents than post-oestrous milk. The differences due to oestrus between the cows kept in cubicles and yards were minimal, but the Ayrshire cows tended to show more significant effects than the Friesians, except in the milk cell counts, where the difference was higher in the Friesians.
Observations were made at the evening and morning milkings immediately before, and the corresponding milkings immediately after, cows had either been injected with tuberculin or disturbed by parties of visitors. At the evening milkings both types of disturbance reduced yield and solids-not-fat (SNF) and protein percentages, but the tuberculin tests increased, and the party visits decreased, the fat percentages. For all these parameters compensatory opposite results were obtained at the milkings the following mornings.
1. Aylesbury ducklings, from 8 to 63 d of age, were fed on diets with or without supplemental copper (100 mg/kg). 2. Copper resulted in significant increases in growth rate and significantly smaller caeca both as a proportion of body weight and as the weight of unit length.
A 39 year old Jewish male with a 22 year history of progressive myoclonic epilepsy was found to have Gaucher cells in his sternal bone marrow. The diagnosis of Gaucher's disease was confirmed by the demonstration of beta-glucosidase deficiency in fibroblasts. Although neurological involvement is extremely rare in adults with Gaucher's disease, this disease is another lipidosis which should be considered in patients with progressive myoclonic epilepsy.
Ampicillin was included (25 mg/litre) in the drinking water supplied to growing rats over periods of 2,3,4,5,6,7 or 8 weeks. 32 rats were used in each experimental period, half being given the antibiotic and half being left as controls. The antibiotic increased the liveweight gain in each period, the results being significant after the 2- and 4-week feeding periods. Significant decreases were observed in the average percentage weights of the spleens of the rats given the antibiotic at the end of all the feeding periods except one. The few other significant changes in the percentage weights of other organs were, with one exception, noted at or before the end of the 4th week.
Fasting serum triglyceride and cholesterol measurements, and lipoprotein characterization by ultracentrifugation, were performed in four groups of patients with chronic renal disease (uraemic, short- and long-term haemodialysis and renal transplant recipients) and the results compared with those obtained from age- and sex-matched control subjects. Basal insulin and growth hormone levels, and serum creatinine and albumin concentrations were measured in, and detailed dietary histories taken from patients in each group. The predominant lipid abnormalities were hypertriglyceridaemia and increased very low density lipoproteins (type IV hyperlipoproteinaemia) in both uraemic and haemodialysis patients. Following renal transplantation, a different pattern of hyperlipidaemia was found. Hypercholesterolaemia was more common and hypertriglyceridaemia less common than in the uraemic and haemodialysis group. The lipoprotein abnormalities were increased low density and/or very low density lipoproteins, with types IIa IIb and IV hyperlipoproteinaemia occurring equally frequently. In uraemic and haemodialysis patients, the proportion of carbohydrate in the diet was high, and may have played a role in the genesis of hypertriglyceridaemia. There was a positive correlation between relative body weight and serum triglyceride in the long-term dialysis group. In renal allograft recipients hypertriglyceridaemia could be attributed, at least in part, to obesity, prednisone dosage and the degree of impairment of graft function. The aetiology of hypercholesterolaemia in the transplant recipients was unclear. Neither basal insulin nor growth hormone levels were elevated in any patient group. Uraemic hypertriglyceridaemia is a clearly defined and well documented metabolic abnormality which is not corrected by dialysis. Post-transplantation hyperlipidaemia however, is a condition of variable presentation and multifactorial aetiology.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.