Biomedical subjects
Publications and source records attributed to J O Daramola.
Two cases of congenital hemifacial hypertrophy are described. To our knowledge, this is the first report of this syndrome in a black African population. Possible diagnostic problems are highlighted.
A 45-year-old Nigerian housewife with chronic osteomyelitis associated with osteopetrosis is described and discussed. Haematological and radiographical investigations on routine admission led to the secondary diagnosis of osteopetrosis. To our knowledge, this is the first case of osteomyelitis of jaws associated with osteopetrosis reported in an African.
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A case of osteopetrosis complicated by chronic osteomyelitis of the mandible, pathological fractures, pancytopenia and splenomegaly is presented. Family studies revealed a dominantly inherited pattern.
In a study of occurrence of tumors of the jaw seen in the University College Hospital over a 24-year period, 199 cases of histologically diagnosed ameloblastoma were found. Notable features of these lesions were extreme size at presentation and high frequency of recurrence. Ameloblastoma ranks next in frequency to fibroosseous lesions and salivary gland tumors in this community. The incidence in men exceeds that of women. The mandible was the location in over 85 percent of the cases. Six cases were suspected to have turned malignant following multiple surgical operations.
Twenty-one patients with osteogenic sarcoma were treated at the University College Hospital, Ibadan, Nigeria, during the period from 1960 to 1984. Six of the 21 patients were younger than 20 years of age, and there was a predominance of male patients in the series. The maxilla was involved more frequently than the mandible. Surgery was the only treatment available. All of the patients are presumed to be dead.
The records of the Cancer Registry of University College Hospital in Ibadan, Nigeria, were reviewed for the incidence of adenomatoid odontogenic tumor from 1961-1982. Thirteen cases of the tumor were found. Clinical, histologic, and radiologic features of the 13 cases are reported. Many features were similar to previous reports of this tumor, but an increased ratio of males to females and preference for the mandible was observed. It is suggested that these factors may be peculiar to Nigerians. A few cases showed an unusual posterior location of tumor.
From 1960 to 1983 a total of 14 cases of chondrosarcoma of the jaws were treated at the University College Hospital in Ibadan, Nigeria. The age of the patients ranged from 19 to 55 years (average age, 35 years), and nine of the patients were male. Six of the lesions were located in the maxilla and eight in the mandible. Most of the patients presented too late in the course of the disease to benefit from treatment; only one is known to be still alive.
A review of 133 cases of fibro-osseous lesions seen and treated at the University College Hospital, Ibadan, Nigeria, is presented. The age of patients at time of diagnosis ranged from 4 years to 68 years, although over 56 percent occurred in the first two decades of life. The maxilla was more commonly affected and there was a female preponderance in the incidence. Radical surgery was often indicated and performed because of the extent of lesions when presented. Early attempts at graft reconstructions were largely abandoned because of high failure rates. Tumor recurrences or growth cessations were not predictable as some lesions regressed after minor interventions while others grew rather rapidly following radical surgery.
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Over a 13-year period at the University College Hospital in Ibadan, 152 cases of primary tumors of the jaw (excluding Burkett's lymphoma) were reported. These cases, which consisted entirely of Nigerian children under 19 years of age, were then reviewed and analyzed. The majority of the jaw tumors were benign with fibro-osseous lesions and ameloblastoma predominating.Common clinical features were late presentation and disfigurement which made aggressive surgery imperative. All cases of malignant tumors terminated fatally.
A case of sickle cell osteomyelitis of the mandible is described. The etiologoy and management of the condition is discussed.
A retrospective study of 22 patients who had surgical treatment for recurrent ameloblastoma of the jaws at our clinic, within a period of 16 years, was carried out. (1) The recurrent lesion in 18 patients was due to an inadequate previous operation; (2) massive soft-tissue recurrences even after wide mandibular resection occurred in 4 patients; and (3) a malignant transformation was noted in 1 patient.
The case of an aggressive and malignant ameloblastoma of the maxilla in a 22-year-old Nigerian man has been presented. The features that may lead to the development and diagnosis of malignancy in this type of tumor are briefly described and discussed. The relatively young age of this patient, especially in an environment in which medical advice is sought very late, is noteworthy.
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A Nigerian school boy with the syndrome of multiple jaw cysts, skeletal anomalies, and basal cell nevi is described and discussed. To the authors' knowledge, this is the first report of this syndrome in a black African.