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Biomedical subjects

J Nowicki

Publications and source records attributed to J Nowicki.

At least 19 recordsLinked to original sources
PubMed1986

Cone function and cone interaction in hereditary degenerations of the central retina.

Spectral sensitivity functions and the transient decrease of sensitivity to short wavelengths after the offset of yellow light (transient tritanopia) were measured by increment threshold techniques in patients suffering from hereditary macular degenerations. Color vision defects were determined by arrangement tests and the anomaloscope. Central areolar choroidal dystrophy was found to produce a mild protan defect and to reduce foveal spectral sensitivity throughout the visible spectrum by a factor of 100; it also abolishes transient tritanopia. Electroretinogram (ERG) was normal, electrooculogram (EOG) subnormal. Stargardt's disease, despite numerous fluorescent macular spots, does not abolish transient tritanopia nor does it reduce spectral sensitivity, although scotopic matches were performed on the Nagel anomaloscope. Only in severe, advanced cases was transient tritanopia reduced and spectral sensitivity found to follow the absorption spectrum of rods. Routine ERGs and EOGs were normal. Vitelliform macular degeneration, despite the ophthalmoscopically pronounced dystrophic macula, produced only very small changes in spectral sensitivity and transient tritanopia, although a widened matching range on the Nagel anomaloscope and electrophysiological abnormalities were found. Apparently damage of the retinal circuit which connects long and short wavelength-sensitive cones, caused by hereditary conditions, is different from that caused by retinotoxic drugs.

Adult↗
PubMed1980

[Cerebrospinal fluid glucose, lactate and pyruvate concentration in patients with cerebral infarction after intravenous glucose loading test].

The determinations of the above substances were done in the blood and CSF of 27 patients with cerebral infarction and 10 controls. The glucose level was determined in the blood and CSF and lactate and pyruvate levels in the CSF before and in the 8th and 16th minutes after a glucose load. The 0-toluidine colorimetric method was used for glucose and spectrophotometric methods were applied for determination of lactate and pyruvate. In the patients with recent cerebral infarction as compared with the control group an increase of glucose concentration was found in the blood (statistically significant) and in the CSF (statistically not significant), while the levels of lactate and pyruvate were raised in the CSF before as well as in the 8th and 16th minutes of the test. Absence of a statistically significant difference between lactate and pyruvate concentrations in the CSF in the same patients with recent cerebral infarction before and in the 8th and 16th minutes of the test suggests that glucose in a hypertonic solution failed to exert any significant influence on CSF lactate and pyruvate concentrations. These biochemical findings seem to support the observations of good therapeutic effects of glucose in hypertonic solution in some cases of cerebral infarction.

Adult↗