[Iatrogenic procaine amide-induced lupus with circulating anticoagulant].
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Biomedical subjects
Publications and source records attributed to J Nick.
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Classically, ligation of the deep cerebral veins is incompatible with survival in man. The authors report four cases, three surgical and one medical, of thrombosis of these veins, confirmed by angiography and well tolerated. This tolerance may be explained by anatomical study of collateral systems and corroborated by clinical and experimental findings.
A controlled study on a pragmatic type was performed on 30 patients of both sex, all having recurrent depressions. The efficacy of Clomipramine plus Lithium Carbonate was compared to that of Clomipramine plus placebo. The control consisted in a double-blind study with random sampling of patients. Results were recorded by an independant observer using a rating scale and were analysed statistically. In spite of the bias which was observed it seems possible to conclude. The association of Clomipramine plus Lithium Carbonate has no greater global antidepressive efficacy as compared with Clomipramine plus placebo which means that Lithium does not potentialize nor antagonize the anti depressant effect of Clomipramine. In respect of the number of patients : bipolar depressions (10 cases) unipolar (20 cases) it has not been possible to study the results in these 2 sub groups.
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