Biomedical subjects

J Neufeld

Publications and source records attributed to J Neufeld.

At least 19 recordsLinked to original sources

PubMed2001

A survival strategy for an academic psychiatry department in a managed care environment.

The changing economics of medical practice have had a profound effect on the educational, research, and service missions of academic departments of psychiatry across the country. The authors describe the development of a managed behavioral health care organization in their parent academic health system as a survival strategy for allowing their department to function in a managed care environment. They present a series of lessons learned in this effort to adapt to a highly volatile managed behavioral health care market: know how you fit into your market as well as your institution, form cooperative alliances within and outside of your institution, provide incentives to manage risk, focus on core competencies, innovate in your areas of strength, and collect data.

Academic Medical Centers↗

PubMed2000

Complete response to topotecan of recurrent fallopian tube carcinoma.

OBJECTIVE: To describe the first complete response of recurrent Fallopian tube carcinoma to topotecan. METHODS: A patient with recurrent Fallopian tube carcinoma previously treated with paclitaxel (Taxol) and carboplatin is described. RESULTS: This patient demonstrated a complete clinical response to topotecan. Radiographic and CA-125 measurements were used to determine response. Response was noted after four cycles and a complete response demonstrated after six treatments. CONCLUSION: Topotecan appears active in recurrent Fallopian tube carcinoma.

Aged↗

PubMed1998

Secondary response of ovarian tumors to topotecan treatment.

Three patients presented with ovarian cancer that was initially treated with paclitaxel and platinum-based compounds. Although responses to these agents occurred, tumor progression was evident by elevated CA 125 levels after a period of 11 to 35 months. These patients were then treated with topotecan and exhibited a response and stopped therapy. All patients subsequently had progression of disease. The patients were again treated with topotecan and have experienced favorable responses. All three patients are currently receiving treatment with topotecan and have stable disease. The results presented here suggest that re-treatment with anti-tumor agents, such as topotecan, may be able to elicit a response in tumors previously sensitive to these agents.

Adult↗

PubMed1998

Problem-solving in relation to abuse by a partner.

The present study investigated the usefulness of the construct of abuse-related problem-solving in relation to the reported experience of abuse by a partner in both clinical and nonclinical samples of women. Data were collected from a clinical sample of 101 women who were receiving treatment at a domestic violence shelter and from a nonclinical sample of 635 female undergraduates attending a medium-sized university. Analysis indicated that women in both samples who possessed good abuse-related problem-solving ability reported experiencing less abuse from their partners. The usefulness of this construct as well as its limitations were noted.

Adaptation, Psychological↗

PubMed1996

Renal coccidiosis and other parasitologic conditions in lesser snow goose goslings at Tha-anne River, west coast Hudson Bay.

Lesser snow goose (Chen caerulescens caerulescens) goslings, approximately 5 weeks of age, were collected near the mouth of Tha-anne River, Northwest Territories, Canada, during mid-August 1991. Many dead goslings had been observed in the area from 1988 to 1990. Goslings from near the coast, where habitat degradation by grazing geese was severe, were smaller, weighed less, and had a greater prevalence of renal coccidiosis (Eimeria truncata) and cecal nematode (Trichostrongylus spp.) infection than did goslings from inland areas, where habitat destruction was not evident. Prevalence of infection with intestinal cestodes was greater at inland than at coastal sites. Prevalences of gizzard nematodes (Epomidiostomum spp.) and Leucocytozoon spp. were not significantly different at the two sites. Histological examination of kidneys and examination of kidney homogenates for oocysts were more sensitive methods than gross examination of the kidneys for detecting renal coccidial infection. The number of oocysts present in droppings was not a good indicator of the severity of renal coccidial infection in individual birds; however, the average number of oocysts in droppings was indicative of the average severity of infection among groups of goslings.

Animals↗

PubMed1995

Membrane-interactive phospholipids inhibit HIV type 1-induced cell fusion and surface gp160/gp120 binding to monoclonal antibody.

Membrane-interactive phospholipids (PLs), previously evaluated for activity against HIV-1 in vitro, are known to affect late steps in viral replication. Studies were done to determine the effects of PL analogs on post-translational processing of HIV-1 proteins, binding of viral surface gp160/gp120 to CD4 receptor, and HIV-1-induced cell fusion. Results of this investigation indicated that PL alone (1-octadecanamido-2-ethoxypropyl-rac-3-phosphocholine, CP-51) and PL-AZT conjugate (1-octadecanamido-2-ethoxypropyl-rac-3-phospho-3'- azido-3'-deoxythymidine, CP-92) have no effect on HIV-1-induced syntheses or processing of gp160/gp120, pr51, p24, or p17 (including myristoylation) in infected cells. Progeny HIV-1 particles made in CP-92-treated H9IIIB cells contained gp120, pr51, and p24; however, these virus particles had reduced capacity to bind to CD4+ cells. Both CP-51 and CP-92 inhibited syncytium (cell fusion) formation between treated HIV-1-infected cells and uninfected CD4+ cells, and, they reduced HIV-1 gp160/gp120 binding to CD4+ cells and monoclonal antibody. These results suggest that anti-HIV-1 activity of PL compounds involves alteration of cell surface membranes and viral envelopes. Phospholipid compounds are a novel class of membrane interactive compounds with potential use in blocking the spread of HIV-1 infection and pathogenesis in AIDS.

Antibodies, Monoclonal↗

PubMed1991

Visual control of locomotion: strategies for changing direction and for going over obstacles.

Dynamics of gait adjustments required to go over obstacles and to alter direction of locomotion when cued visually were assessed through the measurement of ground reaction forces, muscle activity, and kinematics. The time of appearance of obstacles of varying heights, their position within the step cycle, and cue lights for direction change were varied. Direction change must be planned in the previous step to reduce the acceleration of the body center of mass toward the landing foot to 0. The inability of steering within the step cycle is due to the incapacity of muscles to rotate the body and translate it along the mediolateral axes. For obstacle avoidance, Ss systematically manipulated the gait patterns as a function of obstacle height and position and the time available within the ongoing step. Greater supraspinal involvement in control of locomotion is found.

Adult↗

PubMed1991

Liver lead burden in hunter-killed ducks from the Coeur d'Alene River Valley of northern Idaho.

Liver lead burden was evaluated in ducks from an area in northern Idaho contaminated with mining waste and lead shot. Hunter-killed ducks with lead shot in their gizzard had a mean liver lead concentration of 15.18 +/- 2.51 micrograms/g wet-weight (N = 23) and ducks without lead shot had a mean liver lead concentration of 4.21 +/- 0.47 micrograms/g wet-weight (N = 85). The most hazardous source of lead for waterfowl in this area has been thought to be mining waste-contaminated soils and sediments. Three sediment samples had a mean concentration of 4,520 micrograms lead/g wet-weight.

Animals↗

PubMed1975

The prophylactic use of Keflex and Keflin in vaginal hysterectomy.

Although the number of severe infections occurring after vaginal hysterectomy are few,they sometimes result in the death of a patient or a protracted hospital course. A prospective double-blind study, using Keflex and Keflin in theraputic doses,was undertaken to elucidate more clearly the effect upon morbidity in vaginal hysterectomy. Cultures were taken form a catheterized urine specimen and the cervix of all patients before surgery. Cultures were repeated on the fourth postoperative day. Morbidity was defined as an oral temperature of 100.6 degrees F. on two separate occasions, 4hours apart in the postoperative period. Of the 60 patients studied thus far, 43.3 percent of the 30 placebo patients exceeded these febrile limits and were determined as thosewith infectious morbidity. Only 13.3 of the 30 patients who received the prophalatic drug showed this morbidity.

Adult↗

PubMed1974