Biomedical subjects
J Naujoks
Publications and source records attributed to J Naujoks.
[Anaerobic meningitis in brain abscess].
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[Predisposed connections of chronic oropharyngitis and chronic otitis media respectively the endocrinium of menopause (author's transl)].
Eventual predisposed clinical connections of chronic oropharyngitis and otitis media chronica respectively of serum levels of menopausal hormones are examined by clinical-statistic methods or laboratory diagnostics (ratio-immunoessay). Statistic means point out that 71% of all patients suffering from chronic otitis media show symptoms of chronic oropharyngitis too. The question of connection naturally cannot be cleared up as a demonstration, but nevertheless predisposition seems to be probable. Hormonal influence in female during menopause seems not to be predisposing in pathogenesis of oropharyngitis seen very often in this age. This is shown by normal serum levels of oestradiol, FSH and LH in 30 women with chronic oropharyngitis.
[Clinical and Histological aspects concerning the myo-epithelial sialadenitis (author's transl)].
Different aspects necessary for the diagnosis of chronic lymphoidocytic myo-epethelial sialoadenitis are discussed. Histological facts are especially mentioned. The prognosis of this disease is dimmed by a frequent appearance of malignant lymphomas. The case of a Sjögren-disease in a seven-year-old male patient is presented.
[Tumors of the salivary glands. A review of pathology and clinical aspects].
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[Conservative therapy of tinnitus (author's transl)].
Conservative therapy of tinnitus presents a theme that is controversial, since the usefulness of almost all the proposed treatments is rarely based on scientific-experimental evidence. The blocking of the stellate ganglion, electric stimulation of the cochlea and the anaesthesia of the plexus tympanicus belong to the domain of surgical treatment methods of tinnitus. Drug therapy is the mainstay of treatment; our own measures are demonstrated. We attempt to give a hypothetic pharmacological interpretation of the efficacy of some drugs that derive essentially from diethylaminoethanol and the group of methylexanthines. We also mention the physical treatment methods such as tinnitus masker, ultrasound and physiotherapy as well as acupuncture. Finally, the more recent psychotherapeutic treatment-modalities, for example biofeedback, hypnosis and medical sleep are mentioned.
[Clinical-morphological variations of chronic oropharyngitis (author's transl)].
Non-specific chronic inflammatory changes of the oropharyngeal posterior wall show a considerable abundance of variations. An own respectively reorganised classification of the various clinical pictures in chronic oropharyngitis is proposed comprising altogether 8 forms. The micromorphological characteristics of these particular variations which showed repeating lymphoepithelial interactions in the infantile hyperplastic oropharyngitis with definable activity stages have been examined. The observed changes of the posterior wall of the pharynx in the infant might be settled in physiological border regions within the frame of general immunological scaffolding. A largely unconcerned epithelium was always imposing in the inflammatory hypertrophic and atrophic oro-pharyngopathies of the adult so that here a rather submucous "lymphatic inflammation picture" is uppermost.
[Causes of respiratory insufficiency].
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[Sudden hearing loss--an emergency. Etiopathogenesis and therapy].
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[The so-called chronic hyperplastic pharyngitis in childhood. A histological screening (author's transl)].
The clinical picture of chronic pharyngitis is well defined but insufficiently clarified as to its morphological nature. In our study of 12 children with chronic pharyngitis who underwent adeno-tonsillectomies small pieces of tissue of the posterior wall of the pharynx were microscopically examined. In most instances inflammatory infiltrations were absent. Present was a variably developed hyperplasia of the lymphatic tissues. In the more pronounced hyperplasias there was a lymphoepithelial disintegration that could account for the clinical manifestations and that perhaps could also be considered as a disposing factor for a bona fide pharyngitis. The micromorphological changes were divided into 4 stages.
[Consulting office tissue banks (author's transl)].
The technicalities of obtaining graft tissues and the methods of preserving homograft ossicles and cartilage are described. The chemical and biological problems of tissue banks are discussed practically in relation to published experiences of others. The techniques for use of homograft ossicles in tympanoplasty surgery are described. The comparative ease of preparation and preservation of homograft ossicles and hyaline cartilage justifies the establishment of tissue banks in the practice of the private otologist.
[A clinical study on allogenetic ossicle-implantation (author's transl)].
Here we report a first three years clinical experience with allogenetic ossicles in middle ear surgery. The several allogenetic implants in tympanoplasty type III are coordinated to symbolic abbreviations for documentation. The technique and biology of Cialit-preservation is summarized. Findings and results vindicate the application of allogenetic ossicles outside large ENT hospitals too.
[Viscosity of blood and sensorineural hearing loss (author's transl)].
A statistical survey about the results of treatment of Pentoxifyllin (Trental) in acute and long-standing sensorineural hearing losses is given. The pharmacological effect of viscosity lowering in such patients is demonstrated. The role of erythrocytes and their behaviour in relation to the viscosity of blood its showed by means of literature.
[Therapeutical results of non-acute perceptive hearing loss with vasoactive medicaments (author's transl)].
67 patients who are suffering from a non-acute perceptive hearing loss were treted by several vasoactive medicaments. Besides pharmacological aspects of derivatives of di-ethyl-amino-ethyl-alcohol and of xanthine were discussed. The therapeutical results were subjected to comparing views.
[Emergency--dyspnea from the viewpoint of an ENT-physician].
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[Draft of a compilation of diagnoses in otorhinolaryngology (author's transl)].
Here we report an attempt to make out a catalog of diagnoses in otorhinolaryngology for intern-clinical interests, which appears suitable to electronic data-processing by its modified six-figure ICD-code. In a supplement to this compilation we make allowance for the overlapping with our neighbouring medical specialities.
[Results in the diagnostic of patients with non-acute conductive hearing loss (author's transl)].
70 patients who are suffering from a sound perception deafness without any acute reason, were stationary examined by a certain diagnostic scheme. We want to report the results of the evaluation of this so-called diagnostic check. Simultaneously the question will be discussed, whether such a diagnostic scheme will meet its expenditure.
[On the sex chromatin and sex chromatin-like nuclear structures in human Purkinje-cells].
INTRODUCTION: Animal experiments have shown that in the course of chromatolysis the nuclear sex chromatin of nerve cells of female mammals changes its customary location at the nucleolus and migrates to the nuclear membrane; moreover, in the nuclei of nerve cells of males there occur under similar conditions nuclear structures which resemble the sex chromatin. It was, therefore, thought of interest to see if similar findings also apply to human Purkinje-cells. MATERIAL AND METHODS: The cerebellum of 100 female and 52 male corpses of various ages was examined. Paraffin sections, 2-5 mum thick, were stained with haemalumeosin and, after hydrolysis by hydrochloric acid, with cresyl violet of Schiff's reagent (Feulgen stain). In each cerebellum 100 Purkinje-cells, whose nuclei showed a well developed nucleolus and an obvious Barr body, were studied. In the cerebellum of 29 female corpses the cells examined showed a marked cytoplasmic chromatolysis; in the Purkinje-cells of the remaining 71 female, and of all the male corpses the stage of chromatolysis was classified according to the degree of dissolution of the Nissl bodies as "feeble", "marked", or as the stage of restitution, characterized by nuclear caps. RESULTS: The sex chromatin was seen as a, mainly, round and compact chromocenter with a maximal diameter of 0.6--1.6 mum. The larger Barr bodies were seen more frequently, if chromatolysis in the corresponding cells was marked. With increasing chromatolysis the Barr body, which usually occupies a perinucleolar location, tended to be found more often at or near the nuclear membrane. In the cerebellum of the males 17.4% of the Purkinje cells studied showed heteropyknotic nuclear structures which could not always be distinguished in size or in appearance from a sex chromatin. They occupied predominantly a perinuclear position. but with increasing chromatolysis they too were seen more frequently in a location which tended to be intermediary or near the nuclear membrane. Not infrequently the nuclei simultaneously presented a granular hyperchromatosis. DISCUSSION: The change in the location of the sex chromatin in the nucleus is considered to be associated with compensatory processes following chromatolysis. These in turn are accompanied by an intranuclear current of materials, such as RNA, towards the periphery of the nucleus, or by changed electric potentials which develop in the affected cells. The variations in size of the Barr body should be attributed to a variable condensation of the corresponding X-chromosome, rather than to polyploidy of the nerve cell nuclei. The sex chromatin-like chromocenters, which are seen in "male" Purkinje-cells in the course of chromatolysis, could be attributed to certain chromosomal segments which have a tendency to heterochromasia...