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Biomedical subjects

J Napolitano

Publications and source records attributed to J Napolitano.

12 recordsLinked to original sources
PubMed1995

Actinic keratosis and dysplasia of the conjunctiva: a clinicopathological study of 45 cases.

OBJECTIVE: To characterize precancerous conjunctival intraepithelial tumours on file at the Armed Forces Institute of Pathology (AFIP). DESIGN: Chart review. SETTING: Registry of Ophthalmic Pathology of the AFIP. NUMBERS: Forty-five patients with intraepithelial neoplastic lesions of the conjunctiva followed for at least 2 years. MAIN OUTCOME MEASURES: Extent; papillomatous pattern; degree of parakeratosis, hyperkeratosis and atypia; and amount of solar elastosis. RESULTS: Based on their histologic appearance, 24 cases were classified as actinic keratosis and 21 cases as dysplasia. Clinically, lesions classified as actinic keratosis tended to be focal and leukoplakic, whereas those classified as dysplasia tended to be diffuse and gelatinous. Two of the lesions classified as actinic keratosis recurred, compared with 13 of the lesions classified as dysplasia. In one patient with dysplasia locally invasive squamous cell carcinoma developed after numerous recurrences, requiring orbital exenteration. The degree of atypia was not correlated with recurrence in either group. CONCLUSIONS: Most intraepithelial neoplastic lesions of the conjunctiva can be readily diagnosed by the ophthalmic pathologist as either actinic keratosis or dysplasia.

Carcinoma in Situ↗
PubMed1988

Antroduodenal motility in children with chronic intestinal pseudo-obstruction.

Chronic intestinal pseudo-obstruction describes a heterogeneous group of disorders characterized by signs and symptoms of intestinal obstruction in the absence of a mechanical lesion. We studied antroduodenal motility in 13 children with pseudo-obstruction. The diagnosis was based on radiographic evidence in all, surgery in 11, and specific pathologic features in four. Antroduodenal motility was abnormal in all 13. Qualitative abnormalities in the patterns of antroduodenal contractions permitted separation into groups: (1) postprandial hypomotility (n = 3), (2) absent migrating motor complexes, with phase 3-like activity at the start of meals (neuropathic variety) (n = 5) (3) very low amplitude or absent contractions (myopathic variety) (n = 2); the remaining patients (n = 3) had other distinctive abnormalities. Cisapride, a new gastrointestinal prokinetic drug, stimulated proximal duodenal contractions in the 30 minutes after a meal in nine of 10 patients tested. These studies indicate that antroduodenal manometry is useful for characterizing intestinal pseudo-obstruction, and cisapride stimulates postprandial duodenal contractions in patients with pseudo-obstruction.

Child↗
PubMed1986

Computed tomography in urothelial tumors of renal pelvis and related filling defects.

Our study includes 12 patients. Of these, six had transitional cell carcinoma, three patients with stones and three patients with blood clots. With the use of computed tomography we were able to arrive at a reasonable staging and diagnosis of the filling defects. Computed tomography is not sufficiently sensitive to recognize microscopic invasion. Reactive fibrosis and postobstructive inflammatory changes can mimic tumor invasion on computed tomography, and in such cases staging will not be accurate.

Aged↗
PubMed1978

Occupational asthma of bakers.

Two cases of bakers with asthma are discussed. The etiologic mechanisms which play a role in baker's asthma are reviewed. Disodium cromoglycate may be used to minimize symptoms in this disease entity.

Adult↗