Search PubMed⌕ Search

Biomedical subjects

J Nagington

Publications and source records attributed to J Nagington.

At least 37 records · Page 2Linked to original sources
PubMed1981

Observations on 10 years' HBs antigenaemia after renal transplantation.

A renal transplant patient became a carrier of HBs Ag within four weeks of a successful transplant. The level of antigenaemia was extremely high, and approximately 3% of the particles were 42 nm Dane particles, although the anti-HBe was present from at least 20 months after transplant. After four years the antigenaemia declined to a low level, and five years later HBs Ag became undetectable for the first time. During the past 18 months, no antigen has been detected although immunosuppression continues and the original kidney is still functional.

Adult↗
PubMed1980

Sinus histiocytosis with massive lymphadenopathy: virological, immunological and morphological studies.

The histiocytes from a patient with sinus histiocytosis were tested for the presence of Epstein-Barr viral nuclear antigen (EBNA) before and after in vitro growth. On both occasions the histiocytes as well as the lymphocytes were EBNA negative. Likewise the profile of EBV viral capsid antibody (VCA) suggests that this virus is unlikely to be directly involved in the development of the disease. The maintenance of an unusually high level of antibodies to EBV and measles, both viruses which produce persistent infections, indicates that the humoral immune response is active. That a normal humoral response occurred in response to mumps virus during the same period suggests that a deficiency in the cell mediated immune response to the persistent viruses might be the reason for the abnormally high antibody levels. The fresh as well as the cultured histiocytes had only Fc receptors. The affected lymph node lymphocytes developed unusual large inclusion bodies following in vitro culture.

Adolescent↗
PubMed1980

Hepatitis B carrier state produced by a blood transfusion.

A renal transplant patient was infected by a transfusion of blood from a chronic carrier of hepatitis B and he also became a symptomless carrier. Stored sera enabled detailed retrospective measurement of the rate of decline of passively transferred HBsAg, anti-HBc, and anti-HBe. Active HBsAg production was detected after two months and anti-HBc after six months; neither HBe nor anti-HBe was actively produced although there were many 42 nm HBV particles in the patient's serum.

Adult↗
PubMed1979

The antibody response in Legionnaires' disease.

From 22 patients with Legionnaires' disease, 86 sera were examined for specific serotype 1 IgM and IgG antibodies by the indirect immunofluorescence technique. No antibody was detectable until 8 days or more from the onset of symptoms. When produced the amount was widely variable and remained detectable for periods from less than 34 days to more than 1 year. Intially IgM antibody predominated, ten patients produced only IgM in the first 21 days, six produced only IgM in the first 28 days and three did not produce IgG at any time. One patient, and possibly a second, produced only IgG antibody. Since IgM antibody was still present in one patient after a year it is important not to accept the presence of this as evidence of very recent infection. It is advisable that any type of serological test for L. pneumophila infection should detect the production of both IgM and IgG antibodies.

Antibodies, Bacterial↗
PubMed1978

Fatal echovirus 11 infections in outbreak in special-care baby unit.

In December, 1977, an outbreak of echovirus 11 infection occurred in the special-care baby unit of the Cambridge Maternity Hospital. 3 neonates died, and of 24 infants on the ward during the epidemic 6 others were infected, 3 with symptoms. 3 infants had similar symptoms but virus could not be isolated. The pathological changes in the 3 fatal infections, have not previously been reported for echovirus 11; nor have fatal infections occurred in an epidemic in a special-care baby unit.

Adult↗
PubMed1977

Reactivation of hepatitis b after transplantation operations.

Surveillance of the staff and patients at the Cambridge Transplant and Dialysis Unit for hepatitis-B infection since 1968 has revealed the onset of antigenaemia in 6 patients in eight years. When the first serum of each patient admitted was examined for anti-HBc antibody, 23 of 380 (6-1%) patients were found positive. Since the presence of anti-HBc is taken to be evidence of previous infection, the occurence of antigenaemia in 3 of the positives when they were immunosuppressed after transplantation is believed to be due to reactivation of latent infection. This is a new factor to be considered in the control of hepatitis B after transplantation;

Carrier State↗
PubMed1977

Corynebacterium haemolyticum infections in Cambridgeshire.

In the Cambridge area, 143 patients infected with Corynebacterium haemolyticum were found during the period May 1967 to December 1974. The pharynx was the commonest site of infection and 100 of the 137 pharyngeal infections were in patients aged between 15 and 25 years. Such patients usually had a sore throat; about half of them also had a maculopapular rash. The organism and the clinical features which we have come to regard as typical of this infection are briefly described.

Adolescent↗