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Biomedical subjects

J N Sharma

Publications and source records attributed to J N Sharma.

115 records · Page 7Linked to original sources
PubMedDate not supplied

Evidence of rheumatoid arthritis in ancient India.

The scarcity of references in ancient medical literature to any disease resembling rheumatoid arthritis (RA) has led many Western rheumatologists to believe that rheumatoid arthritis is a disease of relatively recent origin. In a recent paper on this problem, Short traces the first adequate description of what was probably rheumatoid arthritis to Thomas Sydenham (1624-1689) and emphasizes that European and Greek medical literature before Sydenham's time may have confused gout and other forms of polyarthritis as manifestations of the same disease (1). Studies in human paleopathology have as yet produced no convincing evidence for the existenct of RA in ancient human remains, but Short suggested that a study of the ancient medical literature of the Eastern civilizations may provide some new information on the true antiquity of rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Standard curves for mid arm circumference and mid-arm/head circumference ratio in newborns.

One Thousand singleton neonates, between 28 and 44 weeks of estimated gestational age (EGA) were measured within 48 hours of their birth for upper mid-arm circumference (MAC), head circumference (HC) and birth weight (BW). Regression analysis was used to draw standard curves for MAC versus EGA and mid-arm circumference/head circumference ratio (MAC/HC) versus EGA. Correlation coefficients were 0.961 for MAC versus EGA and 0.889 for MAC/HC versus EGA (p less than 0.001). MAC, MAC/HC and HC were also highly correlated with birth weight (p less than 0.001). These standard curves make available a discriminating method for evaluation of intra-uterine growth and a non-invasive technique for following somatic protein status in growing preterm infants.

Anthropometry↗
PubMedDate not supplied

Serum phenytoin levels with different brands.

Four brands of phenytoin were studied in 60 newly diagnosed epileptic patients randomly and equally placed in 4 groups. Serum phenytoin levels were estimated by EMIT and spectrophotometric methods both of which gave close values with good correlation (r = 0.985). Average serum levels and the incidence of remission achieved with the 4 brands varied within statistical scatter; thus these 4 brands manifested equivalent therapeutic efficacy. In 22 patients serum level was less than 5 micrograms/ml, in 9 of whom attacks remained uncontrolled. In 38 patients serum level exceeded 5 micrograms/ml in 2 of whom attacks were uncontrolled. In 44 out of 60 patients the 2 weeks serum levels were significantly higher (P less than 0.001 by paired t-test) than those after 3 months. In the remaining 16 patients the serum levels at 3 months were significantly higher than at 2 weeks levels (P less than 0.01).

Adult↗