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Biomedical subjects

J N Fiessinger

Publications and source records attributed to J N Fiessinger.

At least 271 records · Page 15Linked to original sources
PubMed1975

[Correlation between scleroderma and Sjogren's syndrome. Value of systematic biopsy of the labial salivary glands].

Thirty one patients with generalised scleroderma underwent labial biopsy. Sixteen showed a nodular infiltration of the accessory salivary glands indicative of Sjögren's syndrome. In 21, intralobular fibrosis was present. More common in those forms with extensive cutaneous involvement, collagenous fibrosis would appear to be a direct manifestation of scleroderma. The frequency of these abnormalities poses the problem of immunological competence with respect to lymphocytic labial infiltrates in generalised scleroderma.

Biopsy↗
PubMed1975

[Radiological and endoscopic study of the esophagus in 33 cases of generalized scleroderma].

The radiological and endoscopic picture of the oesophagus was investigated in 33 patients with generalised sclerodermia. Signs of involvement were noted in 26 subjects, whereas symptoms of such involvement had been observed in 13 only. Screening for oesophageal sclerodermia sites requires accurate assessment of oesophageal kinetics. Fibroscopic examination gives equally reliable evidence of involvement in the form of two distinctive signs: absence of peristaltic contractions in the lower half of the oesophagus and persistence of a "pool of water" in the organ for over 30 secs following injection of a few cc of water in the lying patient. Endoscopy frequently reveals concomitant peptic oesophagitis (10 cases). This is invisible radiologically. Endoscopy also permits accurate appraisal of the lesions associated with peptic stenosis. Fibroscopic examination of the oesophagus, in fact, could well be made a feature of the evaluation of all patients with actual or suspected generalised sclerodermia, on account of its aid to diagnosis and the early notice it gives of oesophageal complications.

Adult↗
PubMed1975

Discontinued thrombolytic treatment: initial biological results.

Changes in blood coagulation following the action of intermittent treatment with streptokinase are studied : 1) Fibrinogenemia remains at a concentration slightly higher than that obtained after the first 16 hour perfusion. 2) The thrombin time becomes considerably longer on the first day, then becomes shorter and remains slightly long throughout treatment. The theoretical interest of the rise in plasminogen levels during interruption of perfusions of streptokinase is discussed.

Humans↗
PubMed1975

[Intermittent thrombolytic treatment. Results during severe, chronic arterial diseases].

38 patients with severe chronic arteritis of the lower limbs were treated with streptokinase intermittently. All had been refused for surgical operation. One patient died, 4 others had early interruption of treatment. Eleven of the 38 patients had efficient thrombolysis confirmed by arteriography. The facts confirm the possibility of thrombolysis during chronic arterial disease. The fact that the aggravation was recent was favourable factor in prognosis. The eleven patients improved, had severe aggravation of symptomes for less than 2 months. Thus thrombolytic treatment has a place of choice in the treatment of severe arterial disease where surgery is impossible, or dangerous, owing to the uncertain state of the vascular bed below the lesion. Efficacious, it permits reconstructive surgery in cases where it had been at first refused. The use of intermittent treatment, apart from advantages of confort and cost, seems to increase the efficacy of treatment.

Adult↗
PubMed1975

[Radiological and endoscopic investigations of the esophagus in 33 cases of generalized scleroderma (author's transl)].

The esophagus was examined radiologically and endoscopically in 33 patients with generalized scleroderma. 13 patients complained of difficulties which suggested implication of the esophagus, scleroderma was found in the esophagus in 26. Radiological demarcation of location of the scleroderma required investigation of the esophageal peristalsis. Endoscopic examination permits an equally reliable assessment through the identification of characteristic signs: the lack of peristaltic contractions in the lower half of the esophagus, and the persistence of water in the esophagus for more than 30 seconds after injection of a few milliliters in the recumbent patient. Further, a peptic esophagitis can often be recognised endoscopically when it is not detectable radiologically (10 cases) and in cases of peptic stenosis (4 patients) exact location of the lesion is possible.

Adult↗