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Biomedical subjects

J N Fiessinger

Publications and source records attributed to J N Fiessinger.

At least 235 records · Page 13Linked to original sources
PubMed1980

[Current aspects of the treatment of deep venous thromboses by heparin (author's transl)].

The use of heparin by continuous infusion from a electric pump gives very good immediate results in the treatment of venous thromboses. In 58 patients, there was a constant improvement in clinical signs and recurrence of the venous thrombosis was exceptional (2%), pulmonary embolism rare (3.5%) and well tolerated. Constant flow and the surveillance of treatment led to the method ensuring stable blood heparin levels. Mid-term results (8 months) in 43 patients appeared to be less favourable, the prevalence of venous sequelae reaching 50% for iliac phlebitis, 28% for sural phlebitis. The respective advantages and disadvantages of heparin and fibrinolytic agents are discussed.

Adult↗
PubMed1980

Local urokinase in arterial thromboembolism.

Selective intra-arterial urokinase (UK) is effective in treating recent arterial thromboembolism. However, usually only partials lysis is achieved and this treatment seems less effective than intravenous streptokinase. At a dose of 37,500 UCTA/hour it does not produce systemic fibrinolysis. This protocol substantially reduces the risk of systemic bleeding and embolism and extends its applicability to operative patients. The combination of surgery and UK seems particularly promising in patients with atherosclerotic arterial thrombosis.

Adult↗
PubMed1980

[Severe ischemia of the lower limbs after ingestion of LSD].

A case of severe limb ischaemia predominating in the legs in a young female drug addict is reported. Arteriography revealed diffuse spasm of all arteries of the lower limbs associated with localised spasm along the profunda artery in particular. These appearances regressed on control angiography performed 10 days later. The treatment which associated volume expanders and intravenous vasodilatation agents (magnesium sulphate) led to rapid improvement in the clinical condition in 3 days. There were no long-term complications. The causative role of LSD was suggested by the history of greatly increased intake in the period before the onset of symptoms. LSD is a derivative of lysergic acid, the common nucleus of the derivative of the ergot of rye. Analysis of a sample dose taken by the patient showed a very large quantity of LSD and of lysergic acid and a very small amount of other ergot alkaloids known for their peripheral vasoconstrictor effects. The circumstances following peripheral ischaemia are discussed; the association of haschich - LSD does not seem to be a factor. The increased doses and a predisposed vascular system, in common with ergot containing drugs, seem to be the major factors.

Acute Disease↗
PubMed1980

[Thombosis of a persistent sciatic artery: a rare cause of severe ischemia in the lower limb (author's transl)].

Persistence of the primitive axial limb artery is an uncommon developemental anomaly. This artery is called sciatic in account of its connections with the nerve. Usually gluteal aneurysms develop and the anomaly is disclosed by a complication : pain, pulsatile buttock mass, thrombosis or release of emboli. Prophylactic surgical repair of such aneurysms seems reasonable.

Aged↗
PubMed1979

[Raynaud's phenomenone: prospective study of 100 cases (author's transl)].

A prospective study of 100 consecutive patients hospitalised with a Raynaud phenomenone is presented. In 82 patients, a precise etiology was pound, most often a collagen disease (50 cases) and amongst this group generalised scleroderma was the most commun (n = 37). Other etiologies were very divers: inflamatory artertis, atheroma, local mecanical causes, emboligenic. In 18 patients, no etiology was found: the age, the sex, the context and the benign cours in this patients was such that a diagnosis of idiopathic Raynaud's phenomenone. This results lead to the suggestion of a method for the investigation of Raynaud's phenomenone. The consequences are therapeutic, the etiological context foring the base of the treatment prescribe.

Adult↗
PubMed1979

[Thrombosis of the portal and superior mesenteric veins in a patient with a congenital and familial deficiency in antithrombin III (author's transl)].

Thrombosis of the visceral veins is an extremely rare condition in cases of congenital and hereditary deficiency of antithrombin III, associated with recurring venous thorbosis of the limbs. The authors report such a case in a man of 40 years of age, who had this deficiency, associated with thrombosis of the portal and superior mesenteric veins and a portal cavernoma. They stress the frequent association of recurring peripheral vein thrombosis, portal vein thrombosis in adults, and thrombosis of the mesenteric vein, and the importance of systematic measurements of antithrombin III levels in these pathological conditions.

Adult↗