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Biomedical subjects

J N Bloom

Publications and source records attributed to J N Bloom.

26 records · Page 2Linked to original sources

Orbital pseudotumor in the differential diagnosis of pediatric uveitis.

Pediatric orbital pseudotumor may be associated with iritis, unlike the adult form of this disorder. However, orbital pseudotumor is seldom considered in the differential diagnosis of childhood uveitis. We report two cases of children with uveitis who were ultimately diagnosed as having orbital pseudotumor. No proptosis was noted in either child. For those pediatric patients with a persistent or recurrent uveitis and a previous negative diagnostic workup, the possibility of an orbital pseudotumor should be considered and ultrasonography, magnetic resonance imaging, and/or computed tomography performed.

Child↗

Serum antiocular antibodies in patients with juvenile rheumatoid arthritis.

Although the uveitis associated with juvenile rheumatoid arthritis (JRA) is presumed to have an autoimmune etiology, its pathogenesis is unknown. We utilized immunohistochemical techniques to detect the presence of serum antibodies directed against ocular tissues in these patients. The staining patterns of serum from patients with JRA, with and without uveitis, were compared with normal controls. Antibodies directed against epitopes in iris and ciliary body basement membranes, lens epithelium and fibers, Bruch's membrane, and iris and retinal blood vessels were observed in the sera of several individuals. These staining patterns were statistically more frequent among the pauciarticular and polyarticular JRA patients, with and without uveitis, than either the systemic JRA or normal populations. These results demonstrate the presence of antiocular antibodies in the sera of JRA patients, with and without uveitis. Whether those nonuveitic JRA patients with antiocular antibodies will develop uveitis is unknown at this time.

Adolescent↗

A magnetic resonance imaging study of horizontal rectus muscle palsies.

The assessment of extraocular muscle function is usually performed indirectly by an examination of ocular motility. We have utilized magnetic resonance imaging, in both cine and static modes, to directly observe the contractility behavior of the extraocular muscles. This noninvasive technique was applied to the study of patients with horizontal rectus muscle palsies. In all cases, the palsied muscle was of a smaller diameter than its normal counterpart. This size differential was noted in all fields of gaze. Additional studies are required to determine the relative contributions of denervation atrophy and loss of tonus to this diminution of muscle size.

Abducens Nerve↗

Ocular pursuit movement assessment by magnetic resonance imaging.

We describe a new technique for generating cinematic magnetic resonance images. This method produces more physiological imaging of extraocular muscles than our previous method. In addition, this technique provides more comfort for the study subject and results in less head movement artifact.

Humans↗

Retinal perforation in strabismus surgery.

PURPOSE: Perforation of the retina is a major complication of strabismus surgery. The reported incidence of perforation varies from 0.13% to 12%. This study was undertaken to determine, from a large collaborative database, the incidence of suspected and unsuspected retinal and choroidal injury in pediatric horizontal muscle surgery. METHOD: All children with horizontal strabismus surgery seen between September 1992 and October 1995 were examined with Indirect ophthalmoscopy immediately following their procedure. Surgery was performed by both resident and attending physicians. Cases involving muscle reoperation, high myopia, or patients with connective tissue disorders were excluded. RESULTS: Strabismus surgery was performed on 765 patients, who underwent 1129 muscle recessions and 349 muscle resections. These children also had 161 vertical or oblique muscle procedures performed. Intraocular trauma resulting from horizontal muscle surgery was noted in 14 patient, including three retinal perforations. One of these patients was treated with cryotherapy; the other two received no therapy other than intraoperative and postoperative antibiotics. DISCUSSION: The incidence of retinal perforation was 0.4% and the incidence of choroidal injury without perforation was 1.4% in this large series of children undergoing horizontal strabismus surgery. Retinal detachment or endophthalmitis did not develop during the 6-week follow-up period.

Adolescent↗