Blind study of fine-needle aspiration biopsy smears in patients with bioptically normal or cirrhotic livers.
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Biomedical subjects
Publications and source records attributed to J Myren.
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The effect of graded doses of pentagastrin on the gastric scretion of acid was compared in patients with and without gastritis. Biopsies were taken from the body of the stomach. Ten subjects had normal gastric mucosa, eight had superficial gastritis, and 10 atrophic gastritis. Pentagastrin in a dose of 1.5 mug/kg/hr elicited a near maximal HCl response from both the normal gastric mucosa and the mucosa with gastritis. The response to 0.3 mug/kg/hr was significantly lower than the response to 7.5 mug/kg/hr in the subjects with atrophic gastritis, while there was no significant difference in the response between the dose levels in the subjects with a normal mucosa.
In a woman with diarrhoea and the Zollinger-Ellison pattern of gastric secretion, the secretion of fluid and bicarbonate into the duodenum in response to secretin was found to be significantly greater than in controls. No pancreatic tumour was found at operation. The pancreas was, however, larger than normal. The patient did not show symptoms of peptic ulcer disease until vagotomy and pyloroplasty had been performed. A capacity to secrete large amounts of bicarbonate was believed to be the explanation of why she was able to tolerate great amounts of acid.
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