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Biomedical subjects

J Myren

Publications and source records attributed to J Myren.

210 records · Page 12Linked to original sources
PubMedDate not supplied

A small dose of somatostatin inhibits the secretin stimulated secretion of bicarbonate, amylase, and chymotrypsin in man.

The effects of a small dose of somatostatin (0.025 mg/h) on the pancreatic secretion of bicarbonate, amylase, and chymotrypsin during stepwise increasing doses of secretin was examined in six healthy volunteers. The secretion of bicarbonate, amylase, and chymotrypsin in response to secretin was significantly reduced by somatostatin. Both output and concentration of pancreatic enzymes were reduced, whereas the concentration of bicarbonate remained unchanged. The pattern of inhibition suggests that somatostatin is a competitive inhibitor of secretin in the stimulation of pancreatic secretion of bicarbonate, which supports the hypothesis of a direct effect of somatostatin on the exocrine secretory cells of the pancreas. The pattern of inhibition of amylase and chymotrypsin secretion is different and difficult to interpret from the present study, but somatostatin may inhibit also the secretin stimulated pancreatic secretion of enzymes completely, as the inhibitory effect seemed to decline when larger doses of secretin were applied.

Amylases↗
PubMedDate not supplied

Introductory remarks on Crohn's disease. Observations from the OMGE studies.

The first report of Crohn's disease (Cd) or regional enterocolitis may be that of Combe and Saunders from 1806. The first nicely described series of cases with this disease was given by Crohn, Ginzburg and Oppenheimer in 1932. Since then numerous studies have given details of Cd from centres and defined areas. The OMGE-studies give information about the presentation, severity and treatment of Cd and ulcerative colitis (uc) around the world. In a total series of 987 cases with Cd and 1,670 with uc, it was found that the accuracy of the clinical diagnosis was 86 per cent and after adding specialized examinations as endoscopy with biopsy etc. the accuracy became 93 per cent. The ratio between uc and Cd varied from 10:1 to 1:4, and the best indices for Cd were in order pulse rate, temperature, systemic complications, severe pain, distention and bowel habits. In about 60 p. cent of Cd drugs were used, salazopyrine was given to 35 per cent and systemic steroids to 23.5 per cent of cases. 25 per cent of Cd came to surgery, the early postoperative mortality being 3.8 per cent. 17 per cent of patients with Cd were at the first treatment symptomfree compared to 30 per cent of those with uc. The overall mortality was 1 per cent. A four years follow-up of 866 patients, showed that the diagnosis had changed in only 0.7 per cent from Cd to uc, and in 2.6 per cent from uc to Cd.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Cortex Hormones↗
PubMedDate not supplied

The distribution of polyps in the large intestine.

The distribution of polyps of the large intestine was investigated. Comparisons were made between results of autopsy studies and a clinical study consisting of 114 consecutively resected polyps. The shift from distal to proximal predominance of adenomas with increasing age from the 50 to the 80 year age group in autopsy studies, was in accordance with the high frequency of adenomas in the distal part of the large intestine in the prospective clinical study, mean 60 years of age. The present clinical study showed a high frequency of adenomas among men, whereas a tendency towards larger polyps and more polyps larger than 10 mm was seen for women. The present examination confirms the reported discrepancy between a high prevalence of adenomas compared to a much lower prevalence of cancer. Thus, the present results emphasize the need for further studies to gain information on risk factors in polyps or individuals predisposed for malignancy of the large intestine.

Aged↗
PubMedDate not supplied

Psychopharmacologic drugs in the treatment of the irritable bowel syndrome. A double blind study of the effect of trimipramine.

In the present multicentre double blind study of 428 patients with the irritable bowel syndrome a significant beneficial effect was found on abdominal pain, nausea, sleeplessness and depression by using 50 mg of the antidepressive drug, trimipramine, in the evening, as well as 10 mg three times daily. A significant effect was also recorded for the total score of wellbeing during the treatment period of 6 weeks. No side effects were recorded except tiredness in the morning in some patients during the first two weeks.

Adult↗
PubMedDate not supplied

Effects of synthetic secretin on gastric secretion in man.

Five healthy subjects received on one occasion 2 mug/kg-hour of pentagastrin alone and on another occasion in combination with synthetic secretin (Schwarz/Mann) in the dose of 2 U/kg-hour. The gastric and duodenal contents were collected continuously through a gastroduodenal Lagerlöf tube. Polyethylene glycol and 57Co labelled vitamin B12 were used as non absorbable markers in the duodenum and in the stomach, respectively. In each subject synthetic secretin inhibited acid (mean inhibition 17 percent) and stimulated pepsin secretin (mean stimulation 49 percent). The findings indicate that these actions are properties of secretin itself.

Adult↗