[Teratology and maternal imagination].
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Congenital Abnormalities↗
Biomedical subjects
J Moscoso
Publications and source records attributed to J Moscoso.
[Animal regeneration experiments from 1686 to 1765. How to defend preexistence?].
This paper deals with the way in which the pre-existence of germs was defended in the face of experimental conclusions regarding animal regeneration in the period between the turn of the seventeenth century and the 1760's. From the experiments of Claude Perrault (1680), Antoine de Réaumur (1712), Abraham Trembley (1740-44) and Charles Bonnet (1740), it became clear that pre-existence delimited its objective so narrowly as to make it invulnerable to all possible experimental refutation. Moreover, we shall argue that this construction of the objective was linked with a renewed definition of the "community of Practitioners" built upon the notion of "scientific exclusion".
Animal Population Groups↗
Safety, immunogenicity and protective effect of the SPf66 malaria synthetic vaccine against Plasmodium falciparum infection in a randomized double-blind placebo-controlled field trial in an endemic area of Ecuador.
A total of 537 subjects were randomized to receive either SPf66 malaria vaccine against Plasmodium falciparum or placebo in three doses (days 0, 30 and 180). Subjects completing the course of vaccination (230 in the vaccine and 238 in the placebo group) were followed up for a further 12 months. Case detection surveillance was implemented by parasitological cross-sectional surveys every 2 months and by monthly household visits to each participant. Symptomatic subjects were also diagnosed in a local health centre. Minor local side-effects were observed mainly after the second dose in about 19% of the vaccinated subjects and in 3.7% of the placebo group. Thirty days after the third dose the prevalence of anti-SPf66 antibodies was 57% in the vaccine and 8.8% in the placebo groups. The prevaccination prevalence of antibodies measured by indirect immunofluorescence assay increased with age and seemed to be inversely related to anti-SPf66 antibody production. Immune response to SPf66 was independent of age. Vaccine efficacy was calculated based on person-time of exposure. The protective effect considering any malaria episode was 66.8% (95% confidence interval = -2.7-89.3%) and considering only one episode per individual was 60.2% (95% confidence interval = -26-87.5%).
Adolescent↗
Successful excision of an intramural fibroma of the left ventricle.
A 2-year-old boy who presented with unrelated recurrent respiratory infections was found to have an enlarged cardiac silhouette on his chest roentgenogram. Clinical evaluation, echocardiography and cardiac cineangiograms failed to provide an accurate diagnosis. A left ventricular tumor was identified by exploratory thoracotomy and successful excision of an intramural fibroma of the left ventricle subsequently accomplished.
Child, Preschool↗