Search PubMed⌕ Search

Biomedical subjects

J Morley

Publications and source records attributed to J Morley.

At least 217 records · Page 12Linked to original sources
PubMed1966

Vasodilatation in the submaxillary gland of the rabbit.

1. In the rabbit, in contrast to the cat and dog, the vasodilatation and the secretion in the submaxillary gland which accompany parasympathetic nerve stimulation are correspondingly sensitive to atropine block. 2. It is concluded that true vasodilator nerve fibres to the submaxillary gland exist in the chorda tympani nerve of the rabbit. 3. The vasodilatation which follows sympathetic vasoconstriction in the submaxillary gland of the rabbit is small and variable. The possibility that this after-dilatation is due to an adrenergic neurotransmitter agent acting on beta-vascular receptors is discussed.

Animals↗
PubMedDate not supplied

Classification of type 2 diabetes by clinical response to metformin-troglitazone combination and C-Peptide criteria.

OBJECTIVE: To assess the ability of basal and stimulated C-peptide levels and stimulated glucose values after oral administration of glucose to predict a successful response to metformin and troglitazone combination therapy after discontinuation of insulin therapy. METHODS: At the onset of the study, plasma glucose and C-peptide levels were measured in a group of 64 obese patients with insulin-treated type 2 diabetes while they were fasting and 2 hours after a challenge of 100 g of glucose administered orally. Then combination metformin-troglitazone treatment was initiated while insulin therapy was gradually tapered over 8 to 12 weeks. Subjects who successfully tolerated insulin withdrawal after the metformin-troglitazone combination were categorized as non-insulin-requiring responders, whereas those who needed insulin to obtain glycemic control were categorized as insulin-requiring nonresponders. Basal and glucose-stimulated C-peptide levels as well as stimulated glucose values were contrasted in the responder versus nonresponder groups. In a second protocol, eight obese patients with insulin-treated type 2 diabetes who successfully stopped insulin therapy were reassessed for C-peptide and glucose variables during the 2-hour oral glucose tolerance test. This reassessment followed a 12-week period of therapy to determine whether treatment of insulin resistance with the combination of metformin and troglitazone could normalize the impaired glucose tolerance in type 2 diabetes. RESULTS: After metformin-troglitazone therapy, 48 study subjects (75%) could later be managed without insulin, whereas 16 (25%) needed insulin to achieve acceptable glycemic control. In a comparison of the non-insulin-requiring responder and insulin-requiring nonresponder groups, the responder group had significantly higher glucose-stimulated C-peptide levels and much lower stimulated glucose levels. The mean basal plasma C-peptide level was higher in the responder than in the nonresponder group, but a small degree of overlap was found between the two groups. Combination treatment with metformin and troglitazone for 12 weeks resulted in a significant reduction in the C-peptide response and glucose variables after the glucose load. CONCLUSION: The results of this study indicate that stimulated C-peptide and glucose levels may be useful criteria to identify whether combination metformin-troglitazone treatment can successfully replace insulin therapy in the management of obese patients with type 2 diabetes. Inability to normalize glucose intolerance after restoring insulin resistance with insulin sensitizers is supportive of the presence of both disturbed beta-cell function and insulin resistance in patients with type 2 diabetes.

Journal Article↗
PubMedDate not supplied

Cleveland Health Quality Choice Project.

A Cleveland CEO spearheads Health Quality Project. Reliance Electric's John Morley, who chairs the project's leadership group, speaks for a concurrent national reform effort patterned after Cleveland's.

Health Care Coalitions↗