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J Moore

Publications and source records attributed to J Moore.

At least 163 records · Page 9Linked to original sources
PubMed1999

Sexual practices in a cohort of US women with and without human immunodeficiency virus. HERS Study. HIV Epidemiology Research Study.

OBJECTIVES: To compare the frequency and pattern of sexual activities of women infected with human immunodeficiency virus (HIV) relative to uninfected women at the time of enrollment into a multisite cohort study. METHODS: The HIV Epidemiology Research Study (HERS) is a prospective study following 873 HIV-infected and 438 HIV-uninfected women. The baseline protocol included interviews about sexual practices, sociodemographic information, and drug and alcohol use, as well as clinical and laboratory studies. Multiple logistic regression models estimated differences between infected and uninfected women in relation to sexual activity and practice. RESULTS: 77% of infected women and 89% of uninfected women reported at least one sexual partner in the six months before study entry. Among sexually active women, specific practices varied little by HIV serostatus, with the exception of oral sex, which was more frequently performed and received by uninfected women. Despite the high prevalence of sexual activity, infected women were 2.5 times as likely not to have had any recent sexual partners as uninfected women (95% CI = 1.77-3.44). CONCLUSIONS: Women who decrease or altogether stop engaging in sexual partnerships may benefit from direct counseling in relation to underlying loss of sexual affection.

Adolescent↗
PubMed1999

Outpatient laparoscopic cholecystectomy: what predicts the need for admission?

Laparoscopic cholecystectomy (LC) is commonly performed as an outpatient (OP) procedure in selected patients, either in ambulatory surgery units associated with a hospital or in freestanding facilities. To identify factors that may preclude OPLC, a retrospective analysis of all patients who underwent LC by two surgeons from August 1996 through June 1998 was performed. A total of 126 patients were divided into three groups. Group I comprised 102 patients who underwent attempted elective OPLC. Group II comprised 20 patients who underwent LC on an emergent basis. Group III comprised 5 patients who were admitted before LC. Data were gathered regarding patient demographics, preoperative diagnoses, preoperative laboratory values, length of stay after surgery, and complications. These data were analyzed using logistic regression and univariate analysis. Age >60 and American Society of Anesthesiologists (ASA) class >2 appeared to be significant predictors of admission, but when considered together, neither was significant. The diagnosis of acute cholecystitis or biliary pancreatitis was highly predictive of admission in both groups. An ASA class >2 did predict postoperative stay of more than 12 hours. These data suggest that OPLC can be performed safely in unselected patients. However, those patients with an ASA class >2 or with a diagnosis of biliary pancreatitis or acute cholecystitis are more likely to require admission or postoperative stay over 12 hours, and these criteria should be considered relative contraindications to OPLC in free-standing facilities.

Acute Disease↗
PubMed1999

Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period.

BACKGROUND: Functional neuroimaging studies after alcohol cessation have demonstrated that chronic alcohol use globally reduces neuronal activity for several weeks. Less is known about the effects of previous alcohol use patterns on regional brain activity. Multiple previous alcohol detoxifications are associated with a worse clinical course and increased risk of seizures, perhaps due to sensitization of key brain structures. We performed the following imaging study in alcoholics in the postwithdrawal period to determine if blood flow in medial temporal structures would differ as a function of previous alcohol use (i.e., whether regions were kindled or sensitized due to multiple detoxifications). METHODS: Fourteen adults meeting DSM-IV criteria for alcohol dependence (mean age 35, 8 SD; 10 men) and participating in a double-blind detoxification medication study underwent a brain perfusion Tc99 m-ECD (Neurolite) single photon emission computed tomography scan on days 7 through 9 (mean 7.6, .5 SD) after their last drink and 2 to 3 days since their last detoxification medication. Seven nonpsychiatrically ill, nonalcohol-dependent healthy adults were scanned as control subjects. RESULTS: Alcoholics compared with controls had widely reduced relative activity in cortical secondary association areas and relatively increased activity in the medial temporal lobes (p < 0.01). Five alcoholic patients with > or = 2 previous detoxifications were compared with five patients in their first detoxification (age and detoxification medication matched). Multiple detoxification patients had significantly lower relative activity in bilateral anterior temporal poles and medial temporal lobes and in visual cortex (p < 0.01) compared with first episode patients. CONCLUSIONS: These studies are consistent with other studies comparing alcoholics and controls. They also suggest that on day 7 of detoxification, alcoholic subjects with multiple previous detoxifications have decreased visual cortex, medial temporal lobes, and anterior paralimbic blood flow, compared with those in their first detoxification. Further studies seem warranted to confirm these initial exploratory results.

Adult↗
PubMed1999

Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer.

The HER2/neu proto-oncogene is overexpressed in 25% to 30% of patients with breast cancer. Trastuzumab (Herceptin; Genentech, San Francisco, CA), a recombinant humanized monoclonal antibody with high affinity for the HER2 protein, inhibits the growth of breast cancer cells overexpressing HER2. In this phase II study the efficacy and toxicity of weekly administration of trastuzumab was evaluated in 46 patients with metastatic breast cancer whose tumors overexpressed HER2. A loading dose of 250 mg trastuzumab was administered intravenously, which was followed by 10 weekly doses of 100 mg each. Upon completion of this treatment period, patients with no disease progression could receive a weekly maintenance dose of 100 mg. Patients in this trial had extensive metastatic disease, and most had received prior anticancer therapy. Ninety percent of patients achieved adequate serum levels of trastuzumab. Toxicity was minimal, and no antibodies against trastuzumab could be detected. Objective responses were observed in 5 of the 43 evaluable patients, which included 1 complete remission and 4 partial remissions, for an overall response rate of 11.6%. Responses were seen in mediastinum, lymph nodes, liver, and chest wall lesions. Minor responses (seen in 2 patients) and stable disease (14 patients) lasted for a median of 5.1 months. These results demonstrate that trastuzumab is well tolerated and clinically active in patients with HER2-overexpressing metastatic breast cancers who have received extensive prior therapy. The regression of human cancer through the targeting of putative growth factor receptors such as HER2 warrants further evaluation of trastuzumab in the treatment of breast cancer.

Adult↗
PubMed1999

Joint line restoration after revision total knee arthroplasty.

In 99 patients, 107 knee replacements were revised in two centers by two surgeons using a single revision total knee arthroplasty system. A retrospective radiographic review of joint line position before and after revision total knee arthroplasty was made, and compared with the joint line position before primary knee arthroplasty. Prospectively collected Knee Society Clinical Rating Scores were correlated with radiographic findings. The joint line position in unreplaced knee replacements averaged 16 mm, and the joint line position in knee replacements before revision surgery averaged 17 mm. The joint line was elevated by the revision total knee arthroplasty in 85 of 107 knees (79%). After the revision total knee replacement, the joint line elevation averaged 24 mm. The Knee Society Clinical Rating Score after revision surgery averaged 131 points. If the joint line position was elevated more than 8 mm, the Knee Society Clinical Rating Score averaged 125 points, if the joint line was elevated less than 8 mm, the score averaged 141 points. Joint line elevation after revision total knee replacement is a problem. Excessive elevation may result in worse clinical outcomes. Distal femoral augments should be used more often and with greater thicknesses. Standard implants used for revision surgery should have increased distal dimensions.

Aged↗
PubMed1999

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