Search PubMed⌕ Search

Biomedical subjects

J Montgomery

Publications and source records attributed to J Montgomery.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Alterations in the pharmacokinetics of 3H-delta9-tetrahydrocannabinol in mice by bacterial endotoxin.

Mice were pretreated with either bacterial endotoxin (3 mg/kg, ip) or saline 3 hr prior to an ip injection of 100 mg of 3H-delta9-tetrahydrocannabinol (3H-delta9-THC) per kg, a combination that results in synergistic lethality. Five hours after the injection of 3H-delta9-THC, the endotoxin-pretreated mice contained a significantly greater amount of radioactivity in kidney, liver, heart, plasma, urine, and brain than those without pretreatment. However, the plasma and brain levels of the animals tested with both endotoxin and 3H-delta9-THC (100 mg/kg) were significantly less than those in mice treated only with 200 mg of 3H-delta9-THC per kg, a sublethal dose. The percentage of radioactivity corresponding to unchanged 3H-delta9-THC in extracts of livers and brains was significantly greater in the endotoxin-pretreatment group than in controls. The brain level of 3H-delta9-THC in the endotoxin-pretreated mice was 50% higher than that in the saline-pretreated mice 5 hr after 3H-delta9-THC (100 mg/kg) administration. However, the brain levels of 3H-delta9-THC in the mice treated with endotoxin and 3H-delta9-THC (100 mg/kg) was one-third of that in brains of mice receiving the LD50 of 3H-delta9-THC (300 mg/kg).

Animals↗
PubMedDate not supplied

Therapy evaluation and management of patients with hemiplegia.

Appropriate treatment of the hemiplegic patient depends on a thorough evaluation of sensation and motion in the affected extremities. Realistic goals for self-care, mobility, home, and community skills may be then established. The basic role of therapy when dealing with a stroke patient includes preventing and correcting deformities, improving a patient's functional ability, and increasing strength, control, and upper extremity use when appropriate. Medical intervention may be necessary to augment the occupational and physical therapy programs in the areas of relief of pain and correction of deformities.

Activities of Daily Living↗