Search PubMed⌕ Search

Biomedical subjects

J Monteil

Publications and source records attributed to J Monteil.

13 recordsLinked to original sources
PubMed2006

PET scans for decision-making in metastatic renal cell carcinoma: a single-institution evaluation.

OBJECTIVE: Therapeutic decision-making in metastatic renal cell carcinoma (MRCC) is based on conventional radiological evaluation. Fluorodeoxyglucose positron emission tomography (FDG-PET) scans may modify this strategy. METHODS: Patients with MRCC for whom a therapeutic decision had been made underwent an FDG-PET scan in order to complete the standard radiological evaluation. RESULTS: Twenty-four patients and 26 FDG-PET scans were eligible. In 18 patients, metastatic disease was evaluable on the computed tomography (CT) scan; the FDG-PET scan was positive in 16 patients and negative in 10. In 2 patients, the FDG-PET scan was positive while they were considered disease free on radiological evaluation. In 5 patients (20.8%), the previous therapeutic decision was changed. Thirteen patients had a pathological evaluation for 19 sites. One patient out of 13 had a false-positive FDG-PET scan, while 4 sites out of 6 were false-negative. The sensitivity was 75% (95% CI: 47.6-92.7) and the predictive positive value was 92.3% (95% CI: 64-99.8). With a median follow-up of 24 months, 3 patients developed new metastatic sites. CONCLUSION: Our data suggest that, when positive, an FDG-PET scan may modify the decision made; when negative, it should not modify decision-making especially for surgery, owing to its sensitivity.

Adult↗
PubMed2006

Soft water-soluble microgel dispersions: structure and rheology.

The size and structural characteristics of polyacrylamide-based water-soluble microgel dispersions were investigated by optical and rheological methods. Microgel hydrodynamic radii Rh were measured by light scattering and derived from intrinsic shear viscosity [eta]0. The variations of Rh3 and [eta]0 with the crosslink density Nx, follow the scaling law Rh3 congruent withNx(-alpha) with alpha close to 0.63, in good agreement with the simple structural model proposed in this paper showing how the exact value of alpha depends on inner structural details of the microgel. The plateau viscosity versus particle apparent volume fraction shows a monotonous change from hard sphere dispersions (high crosslink density of microgels) to flexible linear polymer solutions. Measurements of the first normal stress difference N1 show that increasing the microgel crosslink density affects the system viscosity more than its elasticity. Under oscillatory shear flow, loss and storage moduli undergo both qualitative and quantitative changes with crosslink density. At moderate concentrations, the elastic modulus is the most affected and its slope in low frequency regime decreases from two to less than one as Nx increases. We discuss the experimental results within the frame of knowledge on linear, branched polymer solutions and soft microgel suspensions.

Acrylic Resins↗
PubMed2004

Assessment of 18F-fluorodeoxyglucose dual-head gamma camera in asbestos lung diseases.

The purpose of this study was to evaluate the performance of 18F-fluorodeoxyglucose (18FDG) imaging via coincidence detection emission tomography (CDET) in identifying malignant lesions in subjects exposed to asbestos. A total of 30 patients exposed to asbestos underwent 18FDG-CDET between January 2000 and June 2003. A CDET scan of the thorax and abdomen was performed 60 min after injection of 18FDG in fasting patients, and results were obtained in slices in three axes. The CDET results were compared to those from computed tomography (CT), and pleural or surgical biopsy in patients with positive 18FDG-CDET results. All primary malignant mesotheliomas accumulated 18FDG (n=6), and, in two patients, CDET findings were superior to those of CT, allowing early detection. In two cases, lung carcinomas with malignant pleural effusion were also detected. There were five false positive CDET results: three unilateral pleural thickening, one rounded atelectasis, and one benign lung nodule. All patients with pleural plaques showed no significant 18FDG uptake. Malignant diseases were detected by 18FDG-CDET imaging with a sensitivity of 89% and specificity of 71%. Coincidence detection emission tomography can identify malignant mesothelioma in selected subjects exposed to asbestos. Coincidence detection emission tomography appears to be a useful noninvasive method for the follow-up of subjects with exposure risk of asbestosis.

Adult↗
PubMed2004

Detection of the sentinel lymph node under local anaesthesia in early-stage breast cancer: feasibility study in a series of 78 unselected patients.

AIMS: To evaluate the feasibility of excision of the sentinel lymph node under local anaesthesia in early-stage breast cancer. METHODS: Sentinel lymph node detection under local anaesthesia was carried out on all patients presenting with breast cancer at Stage T0, T1 or T2 < 3 cm and N0, M0. The lymph node was mapped using a radioisotope and patent blue dye and lymphoscintigraphy was routinely performed. No premedication was given, and local anaesthesia was carried out with xylocaine. The patients underwent tumorectomy one week later under general anaesthesia, with or without complete axillary dissection, depending on the results of the definitive histopathological examination of the sentinel lymph node. RESULTS: 78 patients underwent this procedure over a period of 20 months. The procedure was successful in 76 out of the 78 patients, with one failure in mapping and one failure in detection (detection rate = 97.4%). The mean time to detection was 21 min (range: 6-45). It was unnecessary to interrupt the procedure due to patient discomfort in any of the cases. One allergic reaction to patent blue dye was noted and required corticosteroid therapy without interruption of the procedure. The time to detection was correlated with the experience of the surgeon carrying of the procedure, the patient's body mass index and the number of labelled lymph nodes found at lymphoscintigraphy. CONCLUSION: We have shown that it is feasible to detect the sentinel lymph node under local anaesthesia in an unselected population. Using this procedure, patients can undergo surgery with the knowledge of their axillary lymph node status while at the same time avoiding the uncertainties of an intraoperative examination of the sentinel lymph node--a source of many false negatives, particularly in the event of micrometastases.

Anesthesia, Local↗
PubMed2001

Radioisotopic control for baclofen pump catheter failure.

STUDY DESIGN: Case report of Baclofen pump catheter failure investigated by radioisotope injection. OBJECTIVES: To report a safe and reliable method for evaluating catheter dysfunction. SETTING: France. METHODS: Single case report of failure of Baclofen pump investigated by radioisotope injection. RESULTS: The injection demonstrated the block in the catheter. The catheter failure was not visualised by plain X-ray nor by filling the pump with radio-opaque solution. CONCLUSION: Catheter failure is a common cause of intrathecal drug delivery problems and may be difficult to diagnose. When catheter disconnection, kink, or dislodgement is not visible on X-ray, radioisotopic control is a safe and reliable method for assessment.

Adult↗
PubMed2001

[Value of 18FDG-CDET in the evaluation of operable bronchial cancer].

The purpose of this study was to investigate the utility of 18fluorodeoxyglucose (FDG) coincidence detection position emission tomography (CDET) in the evaluation of metastatic mediastinal lymph nodes in patients with potentially operable non-small-cell lung cancer (NSCLC). A prospective study was performed in thirty patients with newly suspected NSCLC. Thoracic computed tomography (CT), FDG CDET, and invasive surgical staging were performed in patients. Blinded prospective interpretation was performed for each test and compared to pathological staging obtained by mediastinoscopy and/or by thoracotomy. Patients were followed for six months to detect occult metastases. The sensitivity and specificity of CDET for the detection of mediaStinal lymph nodes were 75% and 94.4% respectively. The corresponding value for CT were 50% and 80.9%. Three patients with N1 disease were classified as N0 by CDET. With regard to definitive surgical node staging, CDET could identify nodal disease in 26 patients and CT only in 18 patients (n = 30). FDG full-ring positron emission tomography (PET) is the most accurate non-invasive method for the detection and staging of lung cancer. In addition, FDG CDET shows high accuracy for the detectability of pulmonary lesions with a diameter at least 2 cm and the evaluation of lymph node in NSCLC.

Carcinoma, Non-Small-Cell Lung↗
PubMed2000

[Pharyngo-esophagoplasty by right coloplasty for the treatment of post-caustic pharyngo-laryngeal-esophageal burns: a report of 13 cases].

We report a new technique of pharyngoesophagoplasty by right coloplasty, indicated in postcaustic severe pharyngeal stenosis, analyzing the anatomical and functional results in terms of respiratory tract and phonation as well as digestive tract outcome. We compared our results with those obtained with other procedures. Between March 1995 and September 1998, pharyngoesophagoplasty by right coloplasty was performed in 13 patients. All had severe hypopharyngeal stricture with total obliteration of the two piriform sinuses and the upper esophageal sphincter. Nine patients underwent emergency esophagectomy or esogastrectomy by stripping and four had a cicatricial esophagus. Eight patients underwent tracheotomy before the pharyngoplasty due to burns of the laryngeal margin or airway infections. There was no perioperative mortality. The retrospective analysis in February 1998 with a follow-up of 22 months disclosed two deaths, one from septic shock following pneumnia and one suicide. For the 11 other patients, respiratory function had been restored successfully as the tracheostomy tube had been removed. Eight of the patients were on regular oral diet and the jejunostomy tube had been removed. Three had mild dysphagia and the oral diet was supplemented by jejunostomy tube feedings. These results were most successful compared with those obtained with 29 other patients. Pharyngo-esophagoplasty by right colonic transposition appears to be the method of choice for the reconstruction of post-caustic pharyngeal and esophageal stenosis.

Adult↗
PubMed1999

Field- and flow-dependent trapping of red blood cells on polycarbonate accumulation wall in sedimentation field-flow fractionation.

Sedimentation field-flow fractionation (SdFFF) instrumentation is now mature. Methodological procedure and particle separation development rules are well established even in the case of biological species. However, in some biological applications, retention properties of samples not predicted by any field-flow fractionation (FFF) elution models are observed. It is demonstrated that the trapping of cellular material in the separation system is not related to geometrical instrumentation features but to channel wall characteristics. The physicochemical particle-wall attractive interactions are different depending on the flow-rate and field intensity applied. Separation power in SdFFF for biological species is therefore limited by the intensity of these interactions. In terms of separation, a balance is to be found between external field and flow intensity to limit particle-wall interactions.

Cell Separation↗
PubMed1988

[Complement: a sign of infestation of sheep by Trypanosoma brucei brucei in an experimental model: its evolution following treatment].

Broad variations in complement levels are seen during the course of many infectious diseases, particularly human and animal african trypanosomiasis. In this study, sheep complement is measured by means of its haemolytic activity expressed in 50% haemolytic complement units per ml (HCU50/ml). In healthy sheep, the average value is 23.3 HCU50/ml. Complement levels dramatically decrease five days after subcutaneous inoculation of Trypanosoma brucei brucei and remain undetectable until death of non treated infected animals. Eight infected sheep are treated with graded dosages of melarsoprol when central nervous system involvement appeared. Complement levels rapidly recover normal values after efficient treatment (0.9 and 1.8 mg/kg/d).

Animals↗
PubMed1982

[Neurocristopathic classification of dental abnormalities].

The neural crest of the vertebrae provides the odontoblasts, which by migrating in the stomodeal epithelium induce in the latter the formation of predamantoblasts (enamel cell). The odontoblasts are then the point of departure of tissue interactions (ectodermal and neurectodermal) which characterise dental organogenesis. An analytical neurocristopathic classification of this organogenesis based upon the developmental properties of the odontoblast is suggested: --abnormalities of formation (anodontism, hypodontism); --abnormalities of migration (ectopism); --abnormalities of cell differentiation and multiplication (hypodontism, microdontism and macrodontism, disturbances in odontogenesis and their combinations, disturbances in amelogenesis). "No odontoblast, no tooth". The dental organ is an indicator of the developmental biological activity of the neural crest as well as its neurulation. Abnormalities in dental organogenesis are of predictive value in terms of other abnormalities of cephalogenesis, those related to the differentiation of the other cells of the neural crest (bone, muscle, cartilage) and those related to the neural tube with which they are territorialised: these are dysneurulations. This classification covers the clinical features of dental abnormalities seen in pediatric stomatology.

Humans↗
PubMed1978

[Not Available].

Explore the source record for details and available documents.

France↗